Dodgers vs. Padres Odds & Betting Predictions - May 21, 2026

Dodgers at Padres

12:40 am • SportsNet LA
4 - 0
Starting Pitchers
pitcherteameraw-l
Randy Vasquez logoR.VasquezSan Diego Padres logo4.176-5
Shohei Ohtani logoS.OhtaniLos Angeles Dodgers logo1.477-2

Dodgers at Padres Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Dodgers
50-29
-1.5
-1.5-112
o7.5+100
-198
Padres
40-37
u7.5
+1.5-106
u7.5-120
+164
location pinThursday 12:40 a.m.
May 21, 2026
Petco ParkSan Diego
Dodgers vs. Padres Expert Picks
YBK Picks.com
Last 30d: 15-12-2 (+2.2u)
LAD -1.5-110
1.82u
LAD -185
0.25u
Ohtani in lineup - had been out when pitching. Split with F5 to -200
LAD -205 (F5)
0.25u
Split with full game to -220
Markus Markets
Markus Markets
Last 30d: 40-37-4 (-0.2u)
R.Vasquez u16.5 Outs-130
1u
Sandy Plashkes
Sandy Plashkes
Last 30d: 86-122-3 (-14.7u)
K.Tucker o1.5 Hits + Runs + RBIs-108
1u
Picks Office
Picks Office
Last 30d: 138-140-13 (-12.9u)
LAD -0.5 (F5)-120
0.83u
Join Discord for earlier access: https://discord.gg/HjKxYKdSUy This is the Ohtani window, with a 0.82 ERA and 50 strikeouts in 44 innings tied to a first-five bet. San Diego is not soft, but the Dodgers top order gets Ohtani, Betts, Freeman, Tucker and Smith before the game reaches the bullpen layer. I only need Los Angeles ahead by one after five, and that is the cleaner way to attack this matchup.
Billy Ward
Billy Ward
Last 30d: 17-19-1 (+2.6u)
Under 0.5 (1st Inn)-113
1.13u
FD way off market
Ryan Minion
Ryan Minion
Last 30d: 276-270-14 (+60.6u)
A.Pages o1.5 Total Bases+130
$1.00
F.Tatis o0.5 Singles-105
$1.00
#ACTION ✍️✍️ #SGP
Under 0.5 (1st Inn)-135
$1.35
#ACTION ✍️✍️ #Leadoff
Frank Ammirante
Frank Ammirante
Last 30d: 320-265-11 (+57.1u)
X.Bogaerts o0.5 HR+820
0.1u
A.Pages o0.5 HR+591
0.1u

Dodgers vs. Padres Previews & Analysis

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    Derek Carty's 2 MLB Player Props for Wednesday Afternoon

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    May 20, 2026 UTC
  • Our 4 MLB Best Bets for Wednesday Afternoon article feature image

    Our 4 MLB Best Bets for Wednesday Afternoon

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    May 20, 2026 UTC
  • The Leadoff: Minion's MLB Breakdown and Bets for Wednesday article feature image

    The Leadoff: Minion's MLB Breakdown and Bets for Wednesday

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    May 20, 2026 UTC
  • Dodgers vs Padres: Nick's Pick for Wednesday Night article feature image

    Dodgers vs Padres: Nick's Pick for Wednesday Night

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Prop Odds Comparison

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Line Movement Tracker

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Dodgers vs. Padres Public Betting Percentages

Away Logo

Dodgers

Public

83%

Bets%

17%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Padres
43-3522-1821-1717-1726-18
Dodgers
38-4216-2422-1837-411-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Padres
34-43-117-22-117-2113-20-121-23
Dodgers
37-4317-2320-2036-421-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Padres
41-3721-1920-1819-1522-22
Dodgers
51-2926-1425-1550-281-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
May 20thLADL 4-5+1.5 WO 8LAD +144
May 19thLADW 1-0+1.5 WU 7SD +124
May 17th@SEAW 8-3+1.5 WO 7.5SD +102
May 16th@SEAW 7-4+1.5 WO 7SD +144
May 16th@SEAW 2-0+1.5 WU 7SD +114

Dodgers vs. Padres Injury Updates

Dodgers Injuries

  • Blake Snell
    SP

    Blake Snell has been scratched Friday. Will Klein likely to start a bullpen game.

    Out

  • Enrique Hernandez
    1B

    Hernandez is out with elbow

    Out

  • Wyatt Mills
    RP

    Mills is out with elbow

    Out

  • Bobby Miller
    SP

    Miller is out with shoulder

    Out

  • Landon Knack
    SP

    Knack is out with undisclosed

    Out

  • Gavin Stone
    SP

    Stone is out with shoulder

    Out

Padres Injuries

  • Joe Musgrove
    SP

    Musgrove is out with elbow

    Out

Dodgers vs. Padres Box Score
Dodgers Player Stats
Projected
PITCHERPCIPKER
Shohei Ohtani logoRS.Ohtani, P88540
Edgardo Henriquez logoRE.Henriquez, P11110
Blake Treinen logoRB.Treinen, P12110
Kyle Hurt logoRK.Hurt, P11110
Will Klein logoRW.Klein, P11110
HITTERSH-ABRHRRBI
Shohei Ohtani logo1S.Ohtani, DH1-4211
Shohei Ohtani logo1S.Ohtani, DH1-4211
Mookie Betts logo2M.Betts, SS2-4000
Freddie Freeman logo3F.Freeman, 1B2-5000
Kyle Tucker logo4K.Tucker, RF1-2001
Andy Pages logo5A.Pages, CF0-4000
Max Muncy logo6M.Muncy, 3B1-3100
Will Smith logo7W.Smith, C1-4000
Teoscar Hernandez logo8T.Hernandez, LF1-2112
Hyeseong Kim logo9H.Kim, 2B1-4000
Padres Player Stats
Projected
PITCHERPCIPKER
Randy Vasquez logoRR.Vasquez, P744.103
Wandy Peralta logoLW.Peralta, P231.200
Yuki Matsui logoLY.Matsui, P331.120
Ron Marinaccio logoRR.Marinaccio, P291.211
HITTERSH-ABRHRRBI
Fernando Tatis logo1F.Tatis, 2B1-3000
Miguel Andujar logo2M.Andujar, DH0-4000
Gavin Sheets logo3G.Sheets, 1B1-4000
Manny Machado logo4M.Machado, 3B0-4000
Xander Bogaerts logo5X.Bogaerts, SS0-4000
Jackson Merrill logo6J.Merrill, CF0-1000
Bryce Johnson logo6B.Johnson, CF1-2000
Nick Castellanos logo7N.Castellanos, RF1-3000
Ramon Laureano logo8R.Laureano, LF1-3000
Freddy Fermin logo9F.Fermin, C0-2000

Dodgers vs. Padres Odds Comparison

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Dodgers at Padres Team Totals

MatchupOverUnder
Dodgers
50-29
N/A
N/A
Padres
40-37
N/A
N/A