Giants vs. Diamondbacks Odds & Betting Predictions - September 16, 2025

Giants at Diamondbacks

1:40 am • NBCS-BA
1 - 8
Starting Pitchers
pitcherteameraw-l
Zac Gallen logoZ.GallenArizona Diamondbacks logo4.8313-15
Kai-Wei Teng logoK.TengSan Francisco Giants logo6.372-4

Giants at Diamondbacks Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Giants
0-0
+1.5
+1.5-181
o9-115
+111
Diamondbacks
0-0
u9
-1.5+149
u9-105
-132
location pinTuesday 1:40 a.m.
September 16, 2025
Chase FieldPhoenix
Giants vs. Diamondbacks Expert Picks
Sir Lockselot
Sir Lockselot
Last 30d: 27-59-0 (-22.9u)
SF +108
3u
📚Player Profit 🔑 SF Giants ML +108 (Player Profit) 3u Fade Gallen every time. Giants due for a win, love the +money spot here. Public all over AZ but sharp money on SF. SF has won L4/5 matchups. Code: sirlocks for 10% off every deposit at https://www.playerprofit.com/

Giants vs. Diamondbacks Previews & Analysis

  • Our 4 MLB Best Bets & Parlay for Monday article feature image

    Our 4 MLB Best Bets & Parlay for Monday

    Action Network Staff•
    Sep 15, 2025 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Giants vs. Diamondbacks Public Betting Percentages

Away Logo

Giants

Public

34%

Bets%

66%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Diamondbacks
82-7940-4142-3836-5245-27
Giants
76-8635-4641-4035-5740-28

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Diamondbacks
80-74-739-36-641-38-143-40-537-33-2
Giants
75-80-735-45-140-35-636-55-137-25-6

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Diamondbacks
80-8243-3837-4345-4334-38
Giants
81-8142-3939-4249-4331-37

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 14th@MINW 6-4+1.5 WO 9.5ARI +104
Sep 13th@MINW 5-2+1.5 WU 8.5ARI +114
Sep 13th@MINL 8-9+1.5 WO 8.5MIN +120
Sep 10th@SFW 5-3+1.5 WU 9ARI +110
Sep 10th@SFL 3-5+1.5 LO 7.5SF +121

Giants vs. Diamondbacks Injury Updates

Giants Injuries

  • JT Brubaker
    RP

    Brubaker is out with ribs

    Out

  • Reiver Sanmartin
    RP

    Sanmartin is out with elbow

    Out

Diamondbacks Injuries

    Giants vs. Diamondbacks Box Score
    Giants Player Stats
    Projected
    PITCHERPCIPKER
    Kai-Wei Teng logoRK.Teng, P73450
    Matt Gage logoLM.Gage, P17101
    Joel Peguero logoRJ.Peguero, P150.102
    Joey Lucchesi logoLJ.Lucchesi, P220.202
    Keaton Winn logoRK.Winn, P33211
    HITTERSH-ABRHRRBI
    Jung Hoo Lee logo1J.Lee, CF0-3000
    Willy Adames logo2W.Adames, SS0-4000
    Rafael Devers logo3R.Devers, 1B0-4000
    Matt Chapman logo4M.Chapman, 3B0-3000
    Bryce Eldridge logo5B.Eldridge, DH0-3000
    Heliot Ramos logo6H.Ramos, LF0-3000
    Patrick Bailey logo7P.Bailey, C0-3000
    Casey Schmitt logo8C.Schmitt, 2B2-3111
    Drew Gilbert logo9D.Gilbert, RF0-3000
    Diamondbacks Player Stats
    Projected
    PITCHERPCIPKER
    Zac Gallen logoRZ.Gallen, P96661
    Taylor Rashi logoRT.Rashi, P30230
    Jalen Beeks logoLJ.Beeks, P13110
    HITTERSH-ABRHRRBI
    Geraldo Perdomo logo1G.Perdomo, SS3-3102
    Ketel Marte logo2K.Marte, 2B0-4000
    Corbin Carroll logo3C.Carroll, RF1-4100
    Gabriel Moreno logo4G.Moreno, DH0-3100
    Blaze Alexander logo5B.Alexander, 3B1-3100
    Ildemaro Vargas logo6I.Vargas, 1B1-4002
    Alek Thomas logo7A.Thomas, CF0-2000
    Jordan Lawlar logo7J.Lawlar, PH1-1101
    Jorge Barrosa logo7J.Barrosa, CF0-1000
    James McCann logo8J.McCann, C1-4112
    Jake McCarthy logo9J.McCarthy, LF1-4200

    Giants vs. Diamondbacks Odds Comparison

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    Giants at Diamondbacks Team Totals

    MatchupOverUnder
    Giants
    0-0
    o4.5+102
    u4.5-132
    Diamondbacks
    0-0
    o4.5-110
    u4.5-117