Guardians vs. Tigers Odds & Betting Predictions - September 17, 2025

Guardians at Tigers

10:40 pm • FDSDET
4 - 0
Starting Pitchers
pitcherteameraw-l
Jack Flaherty logoJ.FlahertyDetroit Tigers logo4.648-15
Gavin Williams logoG.WilliamsCleveland Guardians logo3.0612-5

Guardians at Tigers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Guardians
1-2
+1.5
+1.5-174
o8-110
+123
Tigers
4-4
u8.5
-1.5+147
u8-109
-150
location pinWednesday 10:40 p.m.
September 17, 2025
Comerica ParkDetroit
Guardians vs. Tigers Expert Picks
Allan Lem
Allan Lem
Last 30d: 127-98-7 (+10.1u)
Under 4.5 (F5)-130
0.5u
Grant Neiffer
Grant Neiffer
Last 30d: 29-91-2 (-2.2u)
R.Greene o0.5 HR+500
0.25u
Picks Office
Picks Office
Last 30d: 65-71-1 (-3.1u)
CLE +130
2.6u

Guardians vs. Tigers Previews & Analysis

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  • 4 Home Run Prop Bets & Parlay for Wednesday article feature image

    4 Home Run Prop Bets & Parlay for Wednesday

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  • Guardians vs Tigers: System Backed Over/Under article feature image

    Guardians vs Tigers: System Backed Over/Under

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Prop Odds Comparison

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Line Movement Tracker

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Guardians vs. Tigers Public Betting Percentages

Away Logo

Guardians

Public

40%

Bets%

60%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Tigers
73-8941-4032-4949-6424-23
Guardians
86-7639-4247-3433-3651-38

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Tigers
83-72-741-35-542-37-258-49-624-22-1
Guardians
69-87-637-41-332-46-334-34-134-50-5

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Tigers
87-7546-3541-4064-4923-24
Guardians
88-7445-3643-3844-2543-46

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 16thCLEL 5-7-1.5 LO 8CLE -145
Sep 14th@MIAW 2-0-1.5 WU 9DET -135
Sep 13th@MIAL 4-6-1.5 LO 8.5MIA -132
Sep 12th@MIAL 2-8-1.5 LO 7MIA -199
Sep 11th@NYYL 3-9+1.5 LO 8.5NYY +140

Guardians vs. Tigers Injury Updates

Guardians Injuries

  • Ben Lively
    SP

    Lively is out with elbow

    Out

  • John Means
    SP

    Means is out with elbow

    Out

Tigers Injuries

  • Alex Cobb
    SP

    Cobb is out with hip

    Out

  • Jose Urquidy
    SP

    Urquidy is out with arm

    Out

  • Reese Olson
    SP

    Olson is out with shoulder

    Out

  • Ty Madden
    SP

    Madden is out with shoulder

    Out

Guardians vs. Tigers Box Score
Guardians Player Stats
Projected
PITCHERPCIPKER
Gavin Williams logoRG.Williams, P100590
Tim Herrin logoLT.Herrin, P140.210
Matt Festa logoRM.Festa, P80.200
Erik Sabrowski logoLE.Sabrowski, P18100
Jakob Junis logoRJ.Junis, P150.210
Cade Smith logoRC.Smith, P8120
HITTERSH-ABRHRRBI
Steven Kwan logo1S.Kwan, LF1-3000
George Valera logo2G.Valera, DH1-4001
Daniel Schneemann logo2D.Schneemann, PR0-0100
Daniel Schneemann logo2D.Schneemann, DH0-0100
Jose Ramirez logo3J.Ramirez, 3B0-2100
Kyle Manzardo logo4K.Manzardo, 1B1-4000
Jhonkensy Noel logo4J.Noel, 1B0-0000
Bo Naylor logo5B.Naylor, C1-5002
Gabriel Arias logo6G.Arias, SS1-5100
Nolan Jones logo7N.Jones, CF0-4000
Nolan Jones logo7N.Jones, RF0-4000
CJ Kayfus logo8C.Kayfus, RF1-1100
Angel Martinez logo8A.Martinez, PH1-2001
Angel Martinez logo8A.Martinez, CF1-2001
Brayan Rocchio logo9B.Rocchio, 2B0-3000
Tigers Player Stats
Projected
PITCHERPCIPKER
Jack Flaherty logoRJ.Flaherty, P95541
Brant Hurter logoLB.Hurter, P160.211
Tommy Kahnle logoRT.Kahnle, P18110
Bailey Horn logoLB.Horn, P18110
Jose Urquidy logoRJ.Urquidy, P31112
Chris Paddack logoRC.Paddack, P70.110
HITTERSH-ABRHRRBI
Parker Meadows logo1P.Meadows, CF2-3000
Andy Ibanez logo1A.Ibanez, PH0-1000
Trey Sweeney logo1T.Sweeney, SS0-0000
Gleyber Torres logo2G.Torres, 2B0-4000
Kerry Carpenter logo3K.Carpenter, DH1-3000
Spencer Torkelson logo4S.Torkelson, 1B0-4000
Riley Greene logo5R.Greene, LF0-3000
Dillon Dingler logo6D.Dingler, C0-4000
Colt Keith logo7C.Keith, 3B1-3000
Wenceel Perez logo8W.Perez, RF0-4000
Wenceel Perez logo8W.Perez, CF0-4000
Zach McKinstry logo9Z.McKinstry, SS0-2000
Jahmai Jones logo9J.Jones, PH0-0000
Jahmai Jones logo9J.Jones, RF0-0000

Guardians vs. Tigers Odds Comparison

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Guardians at Tigers Team Totals

MatchupOverUnder
Guardians
1-2
o3.5-120
u3.5-108
Tigers
4-4
o4.5+118
u4.5-147