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Padres vs. Giants Odds & Betting Predictions - May 6, 2026

Padres at Giants

7:45 pm • NBCS-BA

San Diego Padres

21-14
@

San Francisco Giants

14-22
Starting Pitchers
pitcherteameraw-l
Adrian Houser logoA.HouserSan Francisco Giants logo7.120-3
Matt Waldron logoM.WaldronSan Diego Padres logo9.880-1

Padres at Giants Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Padres
21-14
-1.5
-1.5+145
o8.5-110
-116
Giants
14-22
u8.5
+1.5-176
u8.5-110
-103
location pinWednesday 7:45 p.m.
May 06, 2026
Oracle ParkSan Francisco
thermometer image63°Fahrenheit
rain image0%Rain
wind image7Wind

Prop Odds Comparison

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No props found

Line Movement Tracker

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Padres vs. Giants Public Betting Percentages

Away Logo

Padres

Public

Home Logo

Giants

62%

Bets%

38%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Giants are 1-4 in their last 5 games.
  • Giants are 2-3 in their last 5 games against the spread
  • Giants are 7-11 in their road games against the spread
  • The totals have gone OVER in 1 of Giants' last 5 games
  • The totals have gone OVER in 8 of Giants' 18 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Giants		15-218-107-114-811-13
Padres		20-1512-78-812-98-6

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Giants		15-19-28-9-17-10-19-36-16-2
Padres		16-18-110-8-16-109-11-17-7

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Giants		14-228-106-125-79-15
Padres		21-1411-810-613-88-6

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
May 6thSDL 5-10-1.5 LO 7.5SD -149
May 5thSDW 3-2+1.5 WU 8SF +112
May 3rd@TBL 1-2+1.5 WU 8TB +104
May 2nd@TBL 1-5-1.5 LU 7.5TB -115
May 1st@TBL 0-3+1.5 LU 7.5TB +117

Giants vs. Padres Injury Updates

Giants Injuries

  • Hayden Birdsong
    SP

    Birdsong is out with arm

    Out

Padres Injuries

  • Joe Musgrove
    SP

    Musgrove is out with elbow

    Out

  • Will Wagner
    3B

    Wagner is out with oblique

    Out

See more MLB Injuries Right Arrow
Padres vs. Giants Starting Lineups
Padres Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Matt Waldron logoRM.Waldron, P0-19.881.9765.27
HITTERSAVGOBPSLGHR
Ramon Laureano logo1R.Laureano, LF.238.301.4265
Manny Machado logo2M.Machado, 3B.221.328.3895
Jackson Merrill logo3J.Merrill, CF.220.283.3624
Miguel Andujar logo4M.Andujar, DH.305.337.4762
Fernando Tatis logo5F.Tatis, RF.252.324.3010
Gavin Sheets logo6G.Sheets, 1B.215.263.4414
Xander Bogaerts logo7X.Bogaerts, SS.262.343.4025
Freddy Fermin logo8F.Fermin, C.161.279.2320
Sung Mun Song logo9S.Song, 2B.000.000.0000
Giants Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Adrian Houser logoRA.Houser, P0-37.121.7144.75
HITTERSAVGOBPSLGHR
Jung Hoo Lee logo1J.Lee, RF.272.321.4002
Casey Schmitt logo2C.Schmitt, 3B.308.359.5425
Luis Arraez logo3L.Arraez, 2B.316.340.3980
Heliot Ramos logo4H.Ramos, LF.270.306.4213
Rafael Devers logo5R.Devers, 1B.218.264.3082
Willy Adames logo6W.Adames, SS.197.236.3433
Bryce Eldridge logo7B.Eldridge, DH.000.333.0000
Drew Gilbert logo8D.Gilbert, CF.255.296.3922
Patrick Bailey logo9P.Bailey, C.152.221.1901

Padres vs. Giants Odds Comparison

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Padres at Giants Team Totals

MatchupOverUnder
Padres
21-14
N/A
N/A
Giants
14-22
N/A
N/A