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Phillies vs. Cubs Odds & Betting Predictions - April 22, 2026

Phillies at Cubs

11:40 pm • NBCS-PH+

Philadelphia Phillies

29-28
2
2 - 7

Chicago Cubs

31-27
7
Starting Pitchers
pitcherteameraw-l
Matthew Boyd logoM.BoydChicago Cubs logo6.002-1
Kyle Backhus logoK.BackhusPhiladelphia Phillies logo4.660-0

Phillies at Cubs Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Phillies
29-28
+1.5
+1.5-131
o7.5-111
+163
Cubs
31-27
u8
-1.5+114
u7.5-109
-195
location pinWednesday 11:40 p.m.
April 22, 2026
Wrigley FieldChicago
Phillies vs. Cubs Expert Picks
The Propfessor
The Propfessor
Last 30d: 38-58-0 (+7.3u)
M.Boyd u5.5 Ks-110
0.91u
OldSchool0909
Last 30d: 27-24-0 (+4.1u)
PHI +166
1u
Picks Office
Picks Office
Last 30d: 137-138-11 (-9.7u)
Under 8-120
1u
Join Discord. All picks posted before 8am https://discord.gg/HjKxYKdSUy
Wags Wins
Wags Wins
Last 30d: 225-287-3 (-84.2u)
Over 8+100
1u
Scott Rickenbach
Scott Rickenbach
Last 30d: 45-47-2 (-3.4u)
PHI +160
1u
Frank Ammirante
Frank Ammirante
Last 30d: 217-244-12 (-12.9u)
Under 4.5 (F5)-125
1.25u
Ryan Minion
Ryan Minion
Last 30d: 338-378-15 (-0.9u)
A.Bohm o1.5 Hits + Runs + RBIs+100
$1.00
D.Swanson o1.5 Hits + Runs + RBIs+112
$1.00
Frank Ammirante
Frank Ammirante
Last 30d: 217-244-12 (-12.9u)
Under 8.5-112
1.12u

Phillies vs. Cubs Previews & Analysis

  • Phillies vs Cubs: Strikeout Prop article feature image

    Phillies vs Cubs: Strikeout Prop

    Tanner McGrath•
    Apr 22, 2026 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Phillies vs. Cubs Public Betting Percentages

Away Logo

Phillies

Public

Home Logo

Cubs

22%

Bets%

78%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Cubs are 2-3 in their last 5 games.
  • Cubs are 2-3 in their last 5 games against the spread
  • Cubs are 11-18 in their road games against the spread
  • The totals have gone OVER in 4 of Cubs' last 5 games
  • The totals have gone OVER in 15 of Cubs' 29 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cubs		23-3512-1711-1814-239-12
Phillies		18-398-2210-1714-264-13

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cubs		33-2515-1418-1119-1814-7
Phillies		24-31-215-14-19-17-120-19-14-12-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cubs		31-2718-1113-1621-1610-11
Phillies		29-2814-1615-1223-176-11

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Apr 21stPHIW 7-4-O 8.5CHC -126
Apr 20thPHIW 5-1+1.5 WU 7.5CHC -111
Apr 19thNYMW 2-1-1.5 LU 8CHC -139
Apr 18thNYMW 4-2+1.5 WU 8.5CHC -118
Apr 17thNYMW 12-4-1.5 WO 10CHC -152

Cubs vs. Phillies Injury Updates

Cubs Injuries

  • Tyler Austin
    1B

    Austin is out with knee

    Out

  • Justin Steele
    SP

    Steele is out with elbow

    Out

Phillies Injuries

  • Max Lazar
    RP

    Lazar is out with oblique

    Out

  • Andrew Painter
    SP

    Andrew Painter was seen walking out to bullpen, he won't start but could be available in relief.

    Questionable

  • Steward Berroa
    RF

    Berroa is out with shoulder

    Out

See more MLB Injuries Right Arrow
Phillies vs. Cubs Box Score
Phillies Player Stats
Projected
PITCHERPCIPKER
Kyle Backhus logoLK.Backhus, P15111
Taijuan Walker logoRT.Walker, P64414
Alan Rangel logoRA.Rangel, P44351
HITTERSH-ABRHRRBI
Kyle Schwarber logo1K.Schwarber, LF0-4000
Trea Turner logo2T.Turner, SS1-4000
Bryce Harper logo3B.Harper, DH0-4000
Felix Reyes logo4F.Reyes, 1B1-4100
Adolis Garcia logo5A.Garcia, RF1-4000
Alec Bohm logo6A.Bohm, 3B2-4100
Edmundo Sosa logo7E.Sosa, 2B2-2001
Bryson Stott logo7B.Stott, PH0-2000
Bryson Stott logo7B.Stott, 2B0-2000
Justin Crawford logo8J.Crawford, CF1-4001
Rafael Marchan logo9R.Marchan, C1-4000
Cubs Player Stats
Projected
PITCHERPCIPKER
Matthew Boyd logoLM.Boyd, P844.252
Ben Brown logoRB.Brown, P372.150
Corbin Martin logoRC.Martin, P12100
Hoby Milner logoLH.Milner, P20120
HITTERSH-ABRHRRBI
Nico Hoerner logo1N.Hoerner, 2B1-5100
Alex Bregman logo2A.Bregman, 3B3-5100
Ian Happ logo3I.Happ, LF1-4102
Seiya Suzuki logo4S.Suzuki, RF2-4112
Michael Busch logo5M.Busch, 1B2-4111
Dansby Swanson logo6D.Swanson, SS0-3000
Moises Ballesteros logo7M.Ballesteros, DH1-4100
Miguel Amaya logo8M.Amaya, C0-4100
Pete Crow-Armstrong logo9P.Crow-Armstrong, CF3-4002

Phillies vs. Cubs Odds Comparison

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Phillies at Cubs Team Totals

MatchupOverUnder
Phillies
29-28
N/A
N/A
Cubs
31-27
N/A
N/A