Pirates vs. Reds Odds & Betting Predictions - September 24, 2025

Pirates at Reds

10:40 pm • SportsNet PT
4 - 3
Starting Pitchers
pitcherteameraw-l
Christian Greene logoH.GreeneCincinnati Reds logo2.767-4
Paul Skenes logoP.SkenesPittsburgh Pirates logo1.9710-10

Pirates at Reds Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Pirates
71-91
-1.5
PK-109
o7-103
+108
Reds
83-79
u7
PK-109
u7-114
-102
location pinWednesday 10:40 p.m.
September 24, 2025
Great American Ball ParkCincinnati
Pirates vs. Reds Expert Picks
Gamblers Dream
Gamblers Dream
Last 30d: 4-5-0 (+10.9u)
CIN +100 (Live)
1u
Firefighter Bets
Firefighter Bets
Last 30d: 136-130-1 (-3.2u)
CIN -125
1u
The Pick Don
The Pick Don
Last 30d: 26-19-0 (+3.8u)
Under 3.5 (F5)-135
1.5u
It doesn’t get much simpler than this when two of my favorite pitchers are facing off. Let’s start with Paul Skenes, who needs no introduction. He’s elite and well on his way to winning the NL Cy Young. Skenes owns a 2.03 ERA and has been far and away the most dominant pitcher since his 2024 debut. He ranks in the 99th percentile in run value and carries one of the best expected batting averages in the league. Meanwhile, the Reds offense has been lifeless all season. Over the past month, they rank just 26th in batting average along with a 88 wRC+. This is not a good lineup, and with the pressure of a playoff push, nerves at the plate will only add to their struggles. Cincinnati has scored just three runs across its last two games. When Skenes faced them in August, he allowed no runs and struck out eight across six innings. On the other side, since returning from injury, Hunter Greene has been outstanding. He’s fresh off a complete game shutout against the Cubs, allowing just one hit over nine innings. That was his second start in three outings where he gave up only a single hit. Greene is striking out batters at a 31.5% clip with a 32.1% chase rate, and his fastball remains one of the best in baseball. Now, he draws the worst road offense in the league (Rockies don’t count). The Pirates are hitting just .215 with a brutal 74 wRC+ away from PNC Park. These are also two very good defensive teams, so hopefully we don’t screwed by errors like last night’s under. I’m also going to avoid the bullpens and stick with the F5 under. I wouldn’t be surprised if this game is 0-0 or 1-0 after five innings. I’m taking this at U3.5 (-135) on Draft Kings, but would take it down to 3 as well.
💰🦡 Jake
💰🦡 Jake
Last 30d: 99-125-6 (+25.6u)
CIN -0.5 (F5)+135
1u
Charlie Wright
Charlie Wright
Last 30d: 15-12-0 (+1.8u)
Under 3.5 (F5)-135
1u
Hunter Greene is coming off a complete game shutout against the Cubs. He allowed just 3 baserunners. Greene has now allowed 2 ERs in 4 home starts since returning from the IL. He draws a Pittsburgh offense that ranks dead last in OPS and wOBA vs. RHP in September. On the other side, it’s Paul Skenes. What else is there to say? He can put the finishing touches on his Cy Young campaign tonight. Cincinnati is in the thick of the NL Wild Card race, but not because of their bats. The Reds are 23rd in wRC+ vs. righties this month.
Lines at Lunch
Lines at Lunch
Last 30d: 92-92-3 (-6.6u)
Under 7-118
1.18u

Prop Odds Comparison

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Line Movement Tracker

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Pirates vs. Reds Public Betting Percentages

Away Logo

Pirates

Public

40%

Bets%

60%

Money%

MLB Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Reds
82-7840-3942-3929-4353-34
Pirates
90-7248-3342-3919-2669-45

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Reds
58-91-1126-45-832-46-320-47-537-44-6
Pirates
61-92-933-43-528-49-417-26-242-65-7

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Reds
83-7944-3538-4339-3343-44
Pirates
71-9144-3727-5422-2348-66

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 23rdPITL 2-4-1.5 LU 8PIT -101
Sep 21stCHCW 1-0-1.5 LU 9CIN -126
Sep 20thCHCW 6-3+1.5 WU 9CIN -114
Sep 19thCHCW 7-4+1.5 WO 8CIN -110
Sep 18thCHCW 1-0-1.5 LU 8.5CIN -145

Pirates vs. Reds Injury Updates

Pirates Injuries

  • Johan Oviedo
    SP

    Oviedo is questionable with elbow

    Questionable

  • Endy Rodriguez
    1B

    Rodriguez is out with elbow

    Out

  • Jared Jones
    SP

    Jones is out with elbow

    Out

Reds Injuries

  • Noelvi Marte
    3B

    Marte is day-to-day with side

    Day-to-Day

  • Reiver Sanmartin
    RP

    Sanmartin is out with elbow

    Out

  • Brandon Williamson
    SP

    Williamson is out for season with elbow

    Out for Season

  • Douglas Ashcraft
    RP

    Ashcraft is out with groin

    Out

  • Chase Burns
    SP

    Burns is out with hip

    Out

  • Julian Aguiar
    SP

    Aguiar is out for season with elbow

    Out for Season

  • Rhett Lowder
    SP

    Lowder is out with elbow

    Out

  • William Spiers
    RP

    Spiers is out with shoulder

    Out

Pirates vs. Reds Box Score
Pirates Player Stats
Projected
PITCHERPCIPKER
Paul Skenes logoRP.Skenes, P85670
Justin Lawrence logoRJ.Lawrence, P24120
Isaac Mattson logoRI.Mattson, P160.201
Dennis Santana logoRD.Santana, P211.121
Dauri Moreta logoRD.Moreta, P180.210
Yohan Ramirez logoRY.Ramirez, P371.120
HITTERSH-ABRHRRBI
Oneil Cruz logo1O.Cruz, CF0-4000
Jack Suwinski logo1J.Suwinski, CF1-1001
Jared Triolo logo2J.Triolo, 3B0-5000
Bryan Reynolds logo3B.Reynolds, RF1-3300
Spencer Horwitz logo4S.Horwitz, 1B3-5003
Alexander Canario logo4A.Canario, PR0-0000
Rafael Flores logo4R.Flores, 1B0-0000
Andrew McCutchen logo5A.McCutchen, DH1-5000
Thomas Pham logo6T.Pham, LF1-3000
Nicholas Gonzales logo7N.Gonzales, SS1-4000
Nicholas Yorke logo8N.Yorke, 2B0-4100
Henry Davis logo9H.Davis, C0-4000
Reds Player Stats
Projected
PITCHERPCIPKER
Christian Greene logoRH.Greene, P96672
Chase Burns logoRC.Burns, P30230
Emilio Pagan logoRE.Pagan, P26110
Antonio Santillan logoRT.Santillan, P17110
Nicholas Martinez logoRN.Martinez, P12100
HITTERSH-ABRHRRBI
Terry Friedl logo1T.Friedl, CF1-5100
Noelvi Marte logo2N.Marte, RF2-6111
Gavin Lux logo3G.Lux, DH0-3001
Spencer Steer logo4S.Steer, 1B1-4000
Elly De La Cruz logo5E.De La Cruz, SS1-5000
Sal Stewart logo6S.Stewart, 3B0-4000
Ke'Bryan Hayes logo6K.Hayes, 3B0-0000
Miguel Andujar logo6M.Andujar, PH0-1000
Santiago Espinal logo6S.Espinal, 3B0-0000
Tyler Stephenson logo7T.Stephenson, C4-5111
William Benson logo8W.Benson, LF1-4000
Matthew McLain logo9M.McLain, 2B0-5000

Pirates vs. Reds Odds Comparison

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Pirates at Reds Team Totals

MatchupOverUnder
Pirates
71-91
o3.5+105
u3.5-135
Reds
83-79
o3.5-103
u3.5-125