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Twins vs. Guardians Odds & Betting Predictions - July 22, 2026

Twins at Guardians

10:40 pm • MNNT

Minnesota Twins

49-53
@

Cleveland Guardians

54-48
Starting Pitchers
pitcherteameraw-l
Slade Cecconi logoS.CecconiCleveland Guardians logo4.554-6
Bailey Ober logoB.OberMinnesota Twins logo4.337-3

Twins at Guardians Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Twins
49-53
+1.5
+1.5-200
o8-105
+105
Guardians
54-48
u7.5
-1.5+165
u8-114
-125
location pinWednesday 10:40 p.m.
July 22, 2026
Progressive FieldCleveland
thermometer image70°Fahrenheit
rain image0%Rain
wind image6Wind
Twins vs. Guardians Expert Picks
Grant Neiffer
Grant Neiffer
Last 30d: 14-85-3 (-8.6u)
B.Buxton o0.5 HR+350
0.25u
K.Clemens o0.5 HR+480
0.25u
Frank Ammirante
Frank Ammirante
Last 30d: 331-373-6 (-39.0u)
B.Ober u1.5 BB-105
1.05u
S.Cecconi o15.5 Outs+116
0.86u
C.DeLauter o0.5 HR+496
0.1u
Charlie DiSturco
Charlie DiSturco
Last 30d: 59-136-8 (+6.1u)
B.Buxton To Hit 1+ Home Runs Yes+350
0.25u
Brian Bitler
Brian Bitler
Last 30d: 47-56-1 (-25.4u)
MIN +113
3u
Adam Kaufman
Adam Kaufman
Last 30d: 122-107-3 (+9.6u)
CLE -122
1.22u

Twins vs. Guardians Previews & Analysis

  • Twins vs Guardians: Today's Best Strikeout Prop article feature image

    Twins vs Guardians: Today's Best Strikeout Prop

    Action Network Staff•
    Jul 22, 2026 UTC
  • Derek Carty's 4 MLB Player Props for Wednesday article feature image

    Derek Carty's 4 MLB Player Props for Wednesday

    Action Network Staff•
    Jul 22, 2026 UTC
  • Opening Pitch: Zerillo's MLB Projections for Wednesday via BARTOLO article feature image

    Opening Pitch: Zerillo's MLB Projections for Wednesday via BARTOLO

    Sean Zerillo•
    Jul 21, 2026 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Twins vs. Guardians Public Betting Percentages

Away Logo

Twins

Public

Home Logo

Guardians

24%

Bets%

76%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Guardians are 3-2 in their last 5 games.
  • Guardians are 3-2 in their last 5 games against the spread
  • Guardians are 27-24 in their road games against the spread
  • The totals have gone OVER in 3 of Guardians' last 5 games
  • The totals have gone OVER in 26 of Guardians' 51 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Guardians		53-4926-2527-2424-3129-15
Twins		52-5026-2526-2513-1938-30

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Guardians		48-5426-2522-2928-2719-25
Twins		56-40-624-23-432-17-217-14-138-25-5

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Guardians		54-4827-2427-2430-2524-20
Twins		49-5326-2523-2817-1531-37

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jul 21stMINW 5-2-1.5 WU 8CLE -157
Jul 20thMINW 13-4+1.5 WO 7.5CLE +111
Jul 19thPITL 1-7+1.5 LO 7PIT -116
Jul 18thPITW 5-3+1.5 WU 8.5CLE -110
Jul 18thPITL 1-7-1.5 LO 7.5PIT -131

Guardians vs. Twins Injury Updates

Guardians Injuries

    Twins Injuries

    • Pablo Lopez
      SP

      Lopez is out with elbow

      Out

    • David Festa
      SP

      Festa is out with shoulder

      Out

    • Travis Adams
      SP

      Adams is out with triceps

      Out

    See more MLB Injuries Right Arrow
    Twins vs. Guardians Starting Lineups
    Twins Starting Lineup
    Projected
    PITCHERW-LERAWHIPK/9
    Bailey Ober logoRB.Ober, P7-34.331.1956.78
    HITTERSAVGOBPSLGHR
    Trevor Larnach logo1T.Larnach, LF.291.380.4497
    Byron Buxton logo2B.Buxton, CF.275.330.57225
    Josh Bell logo3J.Bell, 1B.251.309.42813
    Ryan Jeffers logo4R.Jeffers, DH.287.398.5529
    Kody Clemens logo5K.Clemens, 2B.241.298.48418
    Royce Lewis logo6R.Lewis, 3B.216.294.39010
    Victor Caratini logo7V.Caratini, C.236.325.3637
    Brooks Lee logo8B.Lee, SS.252.309.42914
    Luke Keaschall logo9L.Keaschall, RF.260.349.3484
    Guardians Starting Lineup
    Projected
    PITCHERW-LERAWHIPK/9
    Slade Cecconi logoRS.Cecconi, P4-64.541.4147.00
    HITTERSAVGOBPSLGHR
    Steven Kwan logo1S.Kwan, LF.239.347.2991
    Travis Bazzana logo2T.Bazzana, 2B.248.342.4209
    Chase DeLauter logo3C.DeLauter, DH.288.353.45811
    Brayan Rocchio logo4B.Rocchio, SS.274.337.4069
    Kyle Manzardo logo5K.Manzardo, 1B.209.301.35110
    Kahlil Watson logo6K.Watson, RF.239.264.3411
    Gabriel Arias logo7G.Arias, 3B.243.284.4085
    Patrick Bailey logo8P.Bailey, C.239.276.3853
    Petey Halpin logo9P.Halpin, CF.216.234.3652

    Twins vs. Guardians Odds Comparison

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    Twins at Guardians Team Totals

    MatchupOverUnder
    Twins
    49-53
    N/A
    N/A
    Guardians
    54-48
    N/A
    N/A