White Sox vs. Diamondbacks Odds & Betting Predictions - April 22, 2026

White Sox at Diamondbacks

1:40 am • CHSN
11 - 5
Starting Pitchers
pitcherteameraw-l
Merrill Kelly logoM.KellyArizona Diamondbacks logo3.381-0
Sean Burke logoS.BurkeChicago White Sox logo4.430-2

White Sox at Diamondbacks Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
White Sox
9-14
+1.5
+1.5-161
o9-115
+120
Diamondbacks
13-10
u9.5
-1.5+135
u9-105
-144
location pinWednesday 1:40 a.m.
April 22, 2026
Chase FieldPhoenix
White Sox vs. Diamondbacks Expert Picks
Cam Is Money
Cam Is Money
Last 30d: 103-88-3 (+14.1u)
M.Murakami o1.5 Hits + Runs + RBIs-115
0.87u
OldSchool0909
Last 30d: 148-155-0 (+16.8u)
CWS +135
1.35u
The Degenerates
The Degenerates
Last 30d: 83-81-6 (-1.7u)
ARI -1.5+135
1u
Wags Wins
Wags Wins
Last 30d: 202-229-2 (-15.1u)
Over 9.5+105
1.05u
Billy Ward
Billy Ward
Last 30d: 38-38-4 (-0.6u)
Over 0.5 (1st Inn)-118
1u
Wouldn't go much past this
Doug Ziefel
Doug Ziefel
Last 30d: 275-368-23 (-22.2u)
M.Kelly o4.5 Ks-115
0.5u
RoyalsProps
RoyalsProps
Last 30d: 61-52-6 (+4.3u)
I.Vargas o1.5 Hits + Runs + RBIs-112
1u
Doug Ziefel
Doug Ziefel
Last 30d: 275-368-23 (-22.2u)
Under 9.5-110
0.55u

White Sox vs. Diamondbacks Previews & Analysis

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Prop Odds Comparison

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Line Movement Tracker

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White Sox vs. Diamondbacks Public Betting Percentages

Away Logo

White Sox

Public

12%

Bets%

88%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Diamondbacks
17-67-410-25-211-4
White Sox
11-124-57-7N/A11-12

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Diamondbacks
14-8-17-47-4-14-39-5-1
White Sox
15-85-410-4N/A15-8

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Diamondbacks
13-107-46-65-27-8
White Sox
9-143-66-8N/A9-14

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Apr 19thTORL 4-10+1.5 LO 8TOR -101
Apr 19thTORW 6-2-1.5 WU 9ARI -151
Apr 18thTORW 6-3-1.5 WO 8.5ARI -142
Apr 15th@BALW 8-5+1.5 WO 9ARI +119
Apr 14th@BALW 4-3+1.5 WU 8.5ARI +135

White Sox vs. Diamondbacks Injury Updates

White Sox Injuries

  • Mike Vasil
    RP

    Vasil is out with elbow

    Out

  • Ky Bush
    SP

    Bush is out with elbow

    Out

  • Brooks Baldwin
    LF

    Baldwin is out with elbow

    Out

  • Kyle Teel
    C

    Teel is out with hamstring

    Out

  • Drew Thorpe
    SP

    Thorpe is out with elbow

    Out

Diamondbacks Injuries

  • Corbin Burnes
    SP

    Burnes is out with elbow

    Out

  • Blake Walston
    SP

    Walston is out with elbow

    Out

  • Tyler Locklear
    1B

    Locklear is out with elbow

    Out

  • Cristian Mena
    SP

    Mena is doubtful with shoulder

    Doubtful

White Sox vs. Diamondbacks Box Score
White Sox Player Stats
Projected
PITCHERPCIPKER
Sean Burke logoRS.Burke, P101632
Lucas Sims logoRL.Sims, P16110
Osvaldo Bido logoRO.Bido, P53223
HITTERSH-ABRHRRBI
Andrew Benintendi logo1A.Benintendi, DH2-6100
Munetaka Murakami logo2M.Murakami, 1B3-5211
Miguel Vargas logo3M.Vargas, 3B1-4211
Colson Montgomery logo4C.Montgomery, SS2-5213
Everson Pereira logo5E.Pereira, RF0-3101
Sam Antonacci logo6S.Antonacci, LF2-5113
Chase Meidroth logo7C.Meidroth, 2B1-3200
Tristan Peters logo8T.Peters, CF3-5000
Reese McGuire logo9R.McGuire, C0-2001
Diamondbacks Player Stats
Projected
PITCHERPCIPKER
Merrill Kelly logoRM.Kelly, P1014.158
Taylor Clarke logoRT.Clarke, P161.100
Jonathan Loaisiga logoRJ.Loaisiga, P271.120
Kevin Ginkel logoRK.Ginkel, P15110
Ryan Thompson logoRR.Thompson, P10003
James McCann logoRJ.McCann, P13100
HITTERSH-ABRHRRBI
Ketel Marte logo1K.Marte, 2B1-4000
Corbin Carroll logo2C.Carroll, RF0-3000
Geraldo Perdomo logo3G.Perdomo, SS1-3100
Adrian Del Castillo logo4A.Del Castillo, C0-5000
Lourdes Gurriel logo5L.Gurriel, LF0-3001
Jose Fernandez logo6J.Fernandez, DH1-4100
Nolan Arenado logo7N.Arenado, 3B2-3100
Ildemaro Vargas logo8I.Vargas, 1B1-4113
Alek Thomas logo9A.Thomas, CF2-4111

White Sox vs. Diamondbacks Odds Comparison

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White Sox at Diamondbacks Team Totals

MatchupOverUnder
White Sox
9-14
N/A
N/A
Diamondbacks
13-10
N/A
N/A