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Louisville vs. Indiana Odds & Betting Predictions - December 6, 2025

Louisville at Indiana

7:15 pm • CBS

Louisville Cardinals

21-9
87
87 - 78

Indiana Hoosiers

17-12
78

Louisville at Indiana Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Louisville
21-9
-3.5-110
o162-110
-180
Indiana
17-12
+3.5-110
u162-110
+150
location pinSaturday 7:15 p.m.
December 06, 2025
Gainbridge FieldhouseIndianapolis
Louisville vs. Indiana Expert Picks
Mike McNamara
Mike McNamara
Last 30d: 86-89-1 (+3.6u)
IND +3.5-110
0.28u
Player Prop Savant
Player Prop Savant
Last 30d: 66-70-0 (-12.3u)
Over 160.5-105
1u
Ryan Minion
Ryan Minion
Last 30d: 165-180-2 (+59.8u)
M.Brown o17.5 Pts-130
$1.30
Tickle the Twine
Tickle the Twine
Last 30d: 39-37-0 (-1.5u)
Under 162-110
1u
Ryan Minion
Ryan Minion
Last 30d: 165-180-2 (+59.8u)
LOU -2.5 (1H)-110
$1.00
LOU -4.5-110
$3.00

Louisville vs. Indiana Previews & Analysis

  • Our 4 CBB Best Bets For Saturday article feature image

    Our 4 CBB Best Bets For Saturday

    Action Network Staff•
    Dec 6, 2025 UTC
  • Louisville vs. Indiana: Back More Talented Team article feature image

    Louisville vs. Indiana: Back More Talented Team

    Christian Odjakjian•
    Dec 6, 2025 UTC
  • 2 Spread, O/U Edges Tip at 10 ET article feature image

    2 Spread, O/U Edges Tip at 10 ET

    Alex Kolodziej•
    Dec 6, 2025 UTC
See more NCAAB Coverage Right Arrow

Prop Odds Comparison

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No props found

Line Movement Tracker

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Louisville vs. Indiana Public Betting Percentages

Away Logo

Louisville

Public

Home Logo

Indiana

58%

Bets%

42%

Money%

NCAAB Public Betting Right Arrow

Betting Trends

  • Indiana are 1-4 in their last 5 games.
  • Indiana are 1-4 in their last 5 games against the spread
  • Indiana are 5-6 in their road games against the spread
  • The totals have gone OVER in 2 of Indiana' last 5 games
  • The totals have gone OVER in 8 of Indiana' 18 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Indiana		13-168-105-610-83-6
Louisville		14-169-85-811-110-3

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Indiana		13-168-105-610-83-6
Louisville		11-195-126-79-130-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Indiana		17-12N/AN/A13-52-7
Louisville		21-9N/AN/A16-60-3

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Dec 4th@MINNL 64-73-8.5 LU 144.5MINN -463
Nov 29thCOOKW 100-56-29.5 WO 149.5IND -20000
Nov 26thKSUW 86-69-10.5 WU 164.5IND -562
Nov 20thLINWW 73-53-33 LU 155.5-
Nov 16thIWW 69-61-28.5 LU 157.5-

Louisville vs. Indiana Injury Updates

Louisville Injuries

  • Mikel Brown
    G

    Brown is questionable with undisclosed

    Questionable

Indiana Injuries

  • Jason Drake
    G

    Drake is out with foot

    Out

  • Jordan Rayford
    G

    Rayford is out for season with undisclosed

    Out for Season

See more NCAAB Injuries Right Arrow
Team Stats

25-54 (46%)
Field Goals
26-63 (41%)
24-28 (86%)
Free Throws
15-19 (79%)
13-31 (42%)
3P
11-34 (32%)
34
Rebounds
27
15
Assists
14
13
Turnovers
12
9
Steals
4
5
Blocks
1
19
Fouls
21

Louisville vs. Indiana Odds Comparison

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Louisville at Indiana Team Totals

MatchupOverUnder
Louisville
21-9
N/A
N/A
Indiana
17-12
N/A
N/A