Louisville vs. Pittsburgh Odds & Betting Predictions - September 27, 2025

Louisville at Pittsburgh

4:00 pm • ESPN2

Louisville Cardinals

34

34 - 27

Pittsburgh Panthers

27

MatchupOpenSpreadTotalMoneyline
Louisville 7-1	-6.5	-6.5-115	o53.5-110	-155
Pittsburgh 7-2	u53.5	+6.5-105	u53.5-110	+130

location pin

Saturday 4:00 p.m.

September 27, 2025

Acrisure StadiumPittsburgh

LOU -3.5-115

1u

LOU -4.5+100

1u

LOU u31.5-130

1.3u

Under 57.5-110

1u

Dumbbell theory to the max

LOU -3-110

0.91u

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NCAAF Public Betting

Pittsburgh are 4-1 in their last 5 games.
Pittsburgh are 4-1 in their last 5 games against the spread
Pittsburgh are 3-1 in their road games against the spread
The totals have gone OVER in 3 of Pittsburgh' last 5 games
The totals have gone OVER in 5 of Pittsburgh' 5 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Pittsburgh	7-2	4-1	3-1	5-1	1-1
Louisville	3-5	0-5	3-0	2-5	1-0

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Pittsburgh	7-2	5-0	2-2	4-2	2-0
Louisville	4-4	3-2	1-2	4-3	0-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Pittsburgh	7-2	N/A	N/A	5-1	1-1
Louisville	7-1	N/A	N/A	6-1	1-0

date	opponent	score	spread	over/under	moneyline
Sep 13th	@WVU	L 24-31	-7 L	U 55.5	WVU -275
Sep 6th	CMU	W 45-17	-21.5 W	O 48	PITT -2000
Aug 30th	DUQ	W 61-9	-40.5 W	O 58.5	-
Dec 26th	@TOL	L 46-48	-6.5 L	O 48.5	TOL -238
Nov 30th	@BC	L 23-34	+3.5 L	O 50.5	BC +140

Total

392

Total Yards

339

85

Total Plays

55

4.6117647058823525

Yards Per Play

6.163636363636364

Passing

339

YDS

259

33/51

Comps/Atts

17/32

6.647058823529412

YPA

8.09375

3/1

TDs/INTs

2/3

2/20

Sacks/Yards

2/8

Rushing

53

Rush Yards

80

34

Attempts

23

1.5588235294117647

YPC

3.4782608695652173

1

TDs

0

Turnovers

0

Fumbles Lost

2

1

Interceptions

3

Efficiency

4/4 100%

Redzone

2/3 66.67%

9/19 0%

3rd Down

1/10 0%

0/0 0%

4th Down

1/4 0%

First Downs

23

Total

14

16

Pass

9

6

Rush

3

1

Penalty

2

Misc

9/92

Penalties/Yards

6/38

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MatchupOverUnder
Louisville 7-1	o28-111	u28-118
Pittsburgh 7-2	o25-114	u25-114