Astros vs. Cubs Odds & Betting Predictions - May 22, 2026

Astros at Cubs

6:20 pm • Apple TV+

Houston Astros

Chicago Cubs

pitcher		team	era	w-l
J.Taillon			4.97	2-3
S.Arrighetti			1.50	5-1

MatchupOpenSpreadTotalMoneyline
Astros 20-31	+1.5	+1.5-190	o7-113	+120
Cubs 29-21	u7.5	-1.5+155	u7-108	-143

Friday 6:20 p.m.

May 22, 2026

Wrigley FieldChicago

61°Fahrenheit

0%Rain

12Wind

S.Arrighetti o16.5 Outs-108

1.08u

Under 7.5-130

1.3u

HOU +125

Over 7-110

0.55u

(DK) Bucking the weather trends here because both pitchers have xERAs within 0.1 of 5.00 and SIERAs within 0.17 of 4.50. Both offenses > 110 wRC+ Hm/Rd & > 105 v RHP. Both proj. Lus > 110 v RHP since LY. Two solid defenses (CHC maybe beset), but also a pair of bottom third of the league pen estimators L30 days (HOU 2nd worst).

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No props found

MLB Public Betting

Cubs are 0-5 in their last 5 games.
Cubs are 0-5 in their last 5 games against the spread
Cubs are 9-15 in their road games against the spread
The totals have gone OVER in 3 of Cubs' last 5 games
The totals have gone OVER in 14 of Cubs' 26 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cubs	21-29	12-14	9-15	14-18	7-11
Astros	20-31	11-15	9-16	4-11	16-19

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cubs	28-22	14-12	14-10	17-15	11-7
Astros	27-20-4	16-9-1	11-11-3	9-6	17-14-4

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cubs	29-21	18-8	11-13	21-11	8-10
Astros	20-31	12-14	8-17	5-10	15-20

date	opponent	score	spread	over/under	moneyline
May 20th	MIL	L 0-5	+1.5 L	U 6.5	MIL -112
May 19th	MIL	L 2-5	+1.5 L	U 7.5	MIL +103
May 18th	MIL	L 3-9	-1.5 L	O 10.5	MIL -161
May 17th	@CWS	L 8-9	-1.5 L	O 9	CWS -131
May 16th	@CWS	L 3-8	-1.5 L	O 8.5	CWS -108

Lance McCullers
SP
Lance McCullers Jr. has been scratched Tuesday. Jason Alexander will start.
Out

Tyler Austin
1B
Austin is out with knee
Out
Justin Steele
SP
Steele is out with elbow
Out
Jordan Wicks
SP
Wicks is out with arm
Out

See more MLB Injuries

PITCHER		W-L	ERA	WHIP	K/9
RS.Arrighetti, P		5-1	1.50	1.194	8.75

HITTERS	AVG	OBP	SLG	HR
1J.Pena, SS	.259	.305	.333	0
2I.Paredes, 3B	.244	.333	.378	5
3Y.Alvarez, DH	.303	.412	.605	15
4C.Walker, 1B	.255	.330	.489	11
5J.Meyers, CF	.227	.300	.341	1
6Z.Cole, LF	.186	.205	.419	3
7C.Smith, RF	.206	.299	.319	4
8B.Shewmake, 2B	.291	.291	.491	3
9C.Vazquez, C	.247	.316	.393	3

PITCHER		W-L	ERA	WHIP	K/9
RJ.Taillon, P		2-3	4.97	1.204	7.46

HITTERS	AVG	OBP	SLG	HR
1N.Hoerner, 2B	.264	.348	.391	4
2M.Busch, 1B	.233	.360	.375	4
3A.Bregman, 3B	.249	.332	.350	4
4I.Happ, LF	.215	.353	.429	10
5S.Suzuki, RF	.269	.369	.455	7
6M.Conforto, DH	.322	.431	.610	3
7C.Kelly, C	.297	.381	.398	2
8P.Crow-Armstrong, CF	.225	.302	.357	5
9D.Swanson, SS	.191	.295	.358	7