Brewers vs. Cubs Odds & Betting Predictions - August 21, 2025

Brewers at Cubs

12:05 am • FDSWI

Milwaukee Brewers

6-2

3 - 4

Chicago Cubs

3-4

pitcher		team	era	w-l
C.Rea			3.95	11-7
J.Misiorowski			4.36	5-3

MatchupOpenSpreadTotalMoneyline
Brewers 6-2	+1.5	-1.5+150	o6.5-120	-120
Cubs 3-4	u7	+1.5-182	u6.5-103	+100

Thursday 12:05 a.m.

August 21, 2025

Wrigley FieldChicago

Under 3.5 (F5)-105

1.05u

CHC +105

0.53u

Bet to -102

MIL -115

1.15u

C.Rea o16.5 Outs-110

1.04u

Under 7-115

MIL -119

Under 7-112

📊 49-19 W/L (72.06%) ROI ~ 35.98% L10 ~ 8-2 📈 Cubs Home Under’s After ASB since 2022 ✅ Team is at home ✅ Team is Cubs ✅ Game number in season is more than 100 ✅ Teams ML is less than -160

Under 0.5 (1st Inn)-150

$1.00

MIL -115

1.15u

MIL -115

0.39u

CHC -102

2.94u

MIL -124 (F5)

1.24u

Miz 3.21 SIERA/2.66 xERA, Rea 4.50/4.77 - CHC 107/111/51, MIL 115/109/150 - comparable strong defenses - MIL slightly better pen estimators L30 days (one-third run) - MIL better base running

Brewers vs Cubs: Who To Back on Wednesday Night
Nick Martin•
Aug 20, 2025 UTC

See more MLB Coverage

No props found

MLB Public Betting

Cubs are 2-3 in their last 5 games.
Cubs are 2-3 in their last 5 games against the spread
Cubs are 0-1 in their road games against the spread
The totals have gone OVER in 1 of Cubs' last 5 games
The totals have gone OVER in 3 of Cubs' 6 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cubs	3-4	3-3	0-1	3-3	0-1
Brewers	6-2	5-1	1-1	5-1	1-1

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cubs	3-4	3-3	0-1	3-3	0-1
Brewers	5-3	4-2	1-1	4-2	1-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cubs	3-4	3-3	0-1	3-3	0-1
Brewers	6-2	5-1	1-1	5-1	1-1

date	opponent	score	spread	over/under	moneyline
Aug 20th	MIL	W 4-1	+1.5 W	U 6.5	CHC +102
Aug 19th	MIL	W 6-4	-1.5 W	O 7	CHC -158
Aug 18th	MIL	L 0-7	+1.5 L	U 8	MIL -115
Aug 17th	PIT	W 4-3	-1.5 L	U 7	CHC -198
Aug 16th	PIT	W 3-1	-1.5 W	U 8.5	CHC -229

Tyler Austin
1B
Austin is out with knee
Out
Justin Steele
SP
Steele is out with elbow
Out
Jordan Wicks
SP
Wicks is out with arm
Out
Seiya Suzuki
RF
Suzuki is out with knee
Out

Akil Baddoo
LF
Baddoo is out with quad
Out
Andrew Vaughn
1B
Vaughn is out with hand
Out
Quinn Priester
SP
Priester is out with wrist
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RJ.Misiorowski, P	78	4	5	3
RN.Mears, P	9	1	1	0
RS.Miller, P	18	1	2	0
RA.Uribe, P	6	1	1	0
LJ.Koenig, P	18	1	0	1

HITTERS	H-AB	R	RBI
1S.Frelick, RF	1-4	0	0
2I.Collins, LF	0-3	0	0
3W.Contreras, C	0-5	0	0
4C.Yelich, DH	0-2	2	0
5A.Vaughn, 1B	1-4	0	0
6A.Seigler, 3B	0-3	0	0
7B.Turang, 2B	3-3	1	1
8B.Perkins, CF	0-3	0	1
8C.Durbin, PH	0-1	0	0
9J.Ortiz, SS	0-3	0	0
9D.Jansen, PH	1-1	0	1
9B.Lockridge, PR	0-0	0	0

PITCHER	PC	IP	K	ER
RC.Rea, P	96	5.2	3	2
LC.Thielbar, P	17	1.1	2	0
RB.Keller, P	10	1	1	0
RD.Palencia, P	28	1	2	1

HITTERS	H-AB	R	HR	RBI
1M.Busch, 1B	2-4	0	0	3
2I.Happ, LF	0-4	0	0	0
3S.Suzuki, DH	1-4	0	0	0
4P.Crow-Armstrong, CF	0-3	0	0	0
5C.Kelly, C	0-3	0	0	0
6N.Hoerner, 2B	0-3	0	0	0
7O.Caissie, RF	0-2	1	0	0
8D.Swanson, SS	0-2	1	0	0
9M.Shaw, 3B	1-2	2	1	1