Pirates vs. Reds Odds & Betting Predictions - September 25, 2025

Pirates at Reds

4:40 pm • SportsNet PT

Pittsburgh Pirates

71-91

1 - 2

Cincinnati Reds

83-79

pitcher		team	era	w-l
N.Lodolo			3.33	9-8
B.Ashcraft			2.71	4-4

MatchupOpenSpreadTotalMoneyline
Pirates 71-91	+1.5	+1.5-154	o7.5-111	+144
Reds 83-79	u8.5	-1.5+127	u7.5-108	-172

Thursday 4:40 p.m.

September 25, 2025

Great American Ball ParkCincinnati

Under 4 (F5)+100

CIN -161 (F5)

0.62u

CIN -169

0.59u

Under 8.5-115

0.5u

Must-win game for the Reds. I don’t love that Lodolo is projected to face an entire lineup of righties but the Reds probably treat this game as an all-hands-on-deck and won’t leave him out there if he’s struggling or in trouble. On the other side the Pirates are sending out Braxton Ashcraft, who I like long-term. Owns a 2.62 ERA backed by a 3.45 xERA, so I don’t think it’s fluky. His 8.5% BB% and 0.41 HR/9 ratio have been very good. Let’s back the pitching in this game and take the Under 👇

Thursday's Random MLB Sharp Action Alert!
PJ Walsh•
Sep 25, 2025 UTC
Pirates vs Reds: Spread Pick for This Afternoon
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Sep 25, 2025 UTC

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No props found

MLB Public Betting

Reds are 3-2 in their last 5 games.
Reds are 2-3 in their last 5 games against the spread
Reds are 42-39 in their road games against the spread
The totals have gone OVER in 1 of Reds' last 5 games
The totals have gone OVER in 26 of Reds' 79 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Reds	82-78	40-39	42-39	29-43	53-34
Pirates	90-72	48-33	42-39	19-26	69-45

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Reds	58-91-11	26-45-8	32-46-3	20-47-5	37-44-6
Pirates	61-92-9	33-43-5	28-49-4	17-26-2	42-65-7

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Reds	83-79	44-35	38-43	39-33	43-44
Pirates	71-91	44-37	27-54	22-23	48-66

date	opponent	score	spread	over/under	moneyline
Sep 24th	PIT	L 3-4	-	U 7	PIT -102
Sep 23rd	PIT	L 2-4	-1.5 L	U 8	PIT -101
Sep 21st	CHC	W 1-0	-1.5 L	U 9	CIN -126
Sep 20th	CHC	W 6-3	+1.5 W	U 9	CIN -114
Sep 19th	CHC	W 7-4	+1.5 W	O 8	CIN -110

Johan Oviedo
SP
Oviedo is questionable with elbow
Questionable

Endy Rodriguez
1B
Rodriguez is out with elbow
Out
Jared Jones
SP
Jones is out with elbow
Out

Noelvi Marte
3B
Marte is day-to-day with side
Day-to-Day
Reiver Sanmartin
RP
Sanmartin is out with elbow
Out
Brandon Williamson
SP
Williamson is out for season with elbow
Out for Season
Douglas Ashcraft
RP
Ashcraft is out with groin
Out
Chase Burns
SP
Burns is out with hip
Out
Julian Aguiar
SP
Aguiar is out for season with elbow
Out for Season
Rhett Lowder
SP
Lowder is out with elbow
Out
William Spiers
RP
Spiers is out with shoulder
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RB.Ashcraft, P	72	4.1	5	2
RK.Nicolas, P	24	1.2	3	0
RC.Mlodzinski, P	26	2	0	0

HITTERS	H-AB	R	RBI
1J.Triolo, 3B	0-4	0	0
2N.Gonzales, SS	0-4	0	0
3B.Reynolds, RF	1-4	0	0
4A.McCutchen, DH	0-4	0	0
5T.Pham, LF	1-3	0	0
6J.Bart, C	0-3	0	0
7A.Canario, CF	0-2	0	0
7S.Horwitz, PH	1-1	1	0
7S.Horwitz, 1B	1-1	1	0
8R.Flores, 1B	0-2	0	0
8J.Suwinski, PH	0-1	0	0
8J.Suwinski, CF	0-1	0	0
9N.Yorke, 2B	0-2	0	1

PITCHER	PC	IP	K	ER
LN.Lodolo, P	81	6.1	12	0
RG.Ashcraft, P	8	0.2	1	0
RT.Santillan, P	16	1	1	1
RE.Pagan, P	7	1	0	0

HITTERS	H-AB	R	RBI
1T.Friedl, CF	2-3	1	0
2N.Marte, RF	1-4	1	1
3G.Lux, 2B	2-4	0	1
3M.McLain, 2B	0-0	0	0
4S.Steer, 1B	0-4	0	0
5E.De La Cruz, SS	0-4	0	0
6M.Andujar, DH	2-4	0	0
7W.Benson, LF	1-3	0	0
8J.Trevino, C	0-3	0	0
9K.Hayes, 3B	2-3	0	0