Pirates vs. Reds Odds & Betting Predictions - September 25, 2025

Pirates at Reds

4:40 pm • SportsNet PT

Pittsburgh Pirates

4-3

1 - 2

Cincinnati Reds

4-3

pitcher		team	era	w-l
N.Lodolo			3.33	9-8
B.Ashcraft			2.71	4-4

MatchupOpenSpreadTotalMoneyline
Pirates 4-3	+1.5	+1.5-154	o7.5-111	+144
Reds 4-3	u8.5	-1.5+127	u7.5-108	-172

Thursday 4:40 p.m.

September 25, 2025

Great American Ball ParkCincinnati

Under 4 (F5)+100

CIN -161 (F5)

0.62u

CIN -169

0.59u

Under 8.5-115

0.5u

Must-win game for the Reds. I don’t love that Lodolo is projected to face an entire lineup of righties but the Reds probably treat this game as an all-hands-on-deck and won’t leave him out there if he’s struggling or in trouble. On the other side the Pirates are sending out Braxton Ashcraft, who I like long-term. Owns a 2.62 ERA backed by a 3.45 xERA, so I don’t think it’s fluky. His 8.5% BB% and 0.41 HR/9 ratio have been very good. Let’s back the pitching in this game and take the Under 👇

Under 8.5-118

Ashcraft 3.62 SIERA/3.43 xERA (generally being piggybacked by another young starter), Lodolo poor ERA, but just .299 xwOBA, 18.4 K-BB%, 34.4 HardHit% L30 days - CIN 92/97/85 wRC+ Hm/v RHP/L7 days, 74/77/116 - two above average proj. defensive lineups - PIT 11th best pen estimators L30 days, CIN 17th

Thursday's Random MLB Sharp Action Alert!
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No props found

MLB Public Betting

Reds are 3-2 in their last 5 games.
Reds are 3-2 in their last 5 games against the spread
Reds are 1-0 in their road games against the spread
The totals have gone OVER in 2 of Reds' last 5 games
The totals have gone OVER in 3 of Reds' 6 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Reds	4-3	3-3	1-0	1-0	3-3
Pirates	4-3	1-0	3-3	2-0	2-3

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Reds	3-3-1	3-3	0-0-1	0-1	3-2-1
Pirates	4-3	1-0	3-3	2-0	2-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Reds	4-3	3-3	1-0	1-0	3-3
Pirates	4-3	1-0	3-3	2-0	2-3

date	opponent	score	spread	over/under	moneyline
Sep 24th	PIT	L 3-4	-	U 7	PIT -102
Sep 23rd	PIT	L 2-4	-1.5 L	U 8	PIT -101
Sep 21st	CHC	W 1-0	-1.5 L	U 9	CIN -126
Sep 20th	CHC	W 6-3	+1.5 W	U 9	CIN -114
Sep 19th	CHC	W 7-4	+1.5 W	O 8	CIN -110

Nick Lodolo
SP
Lodolo is out with finger
Out
Hunter Greene
SP
Greene is out with elbow
Out

Jared Jones
SP
Jones is out with elbow
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RB.Ashcraft, P	72	4.1	5	2
RK.Nicolas, P	24	1.2	3	0
RC.Mlodzinski, P	26	2	0	0

HITTERS	H-AB	R	RBI
1J.Triolo, 3B	0-4	0	0
2N.Gonzales, SS	0-4	0	0
3B.Reynolds, RF	1-4	0	0
4A.McCutchen, DH	0-4	0	0
5T.Pham, LF	1-3	0	0
6J.Bart, C	0-3	0	0
7A.Canario, CF	0-2	0	0
7S.Horwitz, PH	1-1	1	0
7S.Horwitz, 1B	1-1	1	0
8R.Flores, 1B	0-2	0	0
8J.Suwinski, PH	0-1	0	0
8J.Suwinski, CF	0-1	0	0
9N.Yorke, 2B	0-2	0	1

PITCHER	PC	IP	K	ER
LN.Lodolo, P	81	6.1	12	0
RG.Ashcraft, P	8	0.2	1	0
RT.Santillan, P	16	1	1	1
RE.Pagan, P	7	1	0	0

HITTERS	H-AB	R	RBI
1T.Friedl, CF	2-3	1	0
2N.Marte, RF	1-4	1	1
3G.Lux, 2B	2-4	0	1
3M.McLain, 2B	0-0	0	0
4S.Steer, 1B	0-4	0	0
5E.De La Cruz, SS	0-4	0	0
6M.Andujar, DH	2-4	0	0
7W.Benson, LF	1-3	0	0
8J.Trevino, C	0-3	0	0
9K.Hayes, 3B	2-3	0	0