Reds vs. Guardians Odds & Betting Predictions - May 16, 2026

Reds at Guardians

10:10 pm • CINR
4 - 7
Starting Pitchers
pitcherteameraw-l
Joey Cantillo logoJ.CantilloCleveland Guardians logo4.056-3
Chris Paddack logoC.PaddackCincinnati Reds logo6.050-2

Reds at Guardians Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Reds
37-40
+1.5
+1.5-156
o8.5-109
+125
Guardians
41-38
u8.5
-1.5+136
u8.5-113
-150
location pinSaturday 10:10 p.m.
May 16, 2026
Progressive FieldCleveland
Reds vs. Guardians Expert Picks
Wags Wins
Wags Wins
Last 30d: 157-146-0 (-8.2u)
CIN +135
1u
YBK Picks.com
Last 30d: 15-12-2 (+2.2u)
CIN +1-110
2u
Derek Carty
Derek Carty
Last 30d: 33-36-1 (+18.8u)
C.Paddack o14.5 Outs-105
1u
THE BAT X is forecasting 16.17 pitching outs for Chris Paddack. Oddsmakers are implying 13.64 pitching outs, so I believe there is value here. If you take the over, you'd be projected to win 74% of the time resulting in a 44% ROI with expected value of $46.58 (based on a $100 wager). This play is good down to at least -205. Love THE BAT X? Get all of Carty's sports betting projections at EV Analytics https://evanalytics.com/subscribe/mlb?ref=zdlkmgz
Sean Zerillo
Sean Zerillo
Last 30d: 148-125-9 (+4.4u)
Over 8.5-102
0.25u
ONLY if you have Under 8.5. Make this 8 now - taking half off original position
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 7-12-2 (-3.7u)
E.De La Cruz u1.5 Hits + Runs + RBIs+100
0.76u
#EV 6.09%
Alex Hinton
Alex Hinton
Last 30d: 69-67-1 (+12.3u)
E.De La Cruz o1.5 Total Bases+135
1u
Picks Office
Picks Office
Last 30d: 138-140-13 (-12.9u)
CIN +145
1u
Join Discord for earlier access: https://discord.gg/HjKxYKdSUy Cincinnati is 6-4 over its last 10 while Cleveland is 4-6 over the same stretch. The Reds have scored 50 runs in that window, enough offense to support a plus-money ML without confirmed starters. Cleveland has allowed 54 runs over its last 10, and this price is too wide for two teams separated by half a game.
Over 4.5 (F5)-120
0.83u
Join Discord for earlier access: https://discord.gg/HjKxYKdSUy This is an early-run bet built around Chris Paddack's 7.63 ERA and 1.663 WHIP. Cleveland has averaged 5.2 runs over the last 10, and Cincinnati games have averaged 9.8 total runs in that same window. The number only asks for 5 runs before the bullpen phase, with both projected lineups carrying enough top-order pressure to get there.
RoyalsProps
RoyalsProps
Last 30d: 57-58-0 (-10.1u)
S.Steer o1.5 Hits + Runs + RBIs-105
1u
Sean Zerillo
Sean Zerillo
Last 30d: 148-125-9 (+4.4u)
Under 8.5-110
0.55u
Update: Want -110 to bet and would keep smaller
Brandon Kravitz
Brandon Kravitz
Last 30d: 55-49-0 (+10.1u)
Under 8.5-104
1.04u
Frank Ammirante
Frank Ammirante
Last 30d: 320-265-11 (+57.1u)
Over 8-115
1u
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 7-12-2 (-3.7u)
CLE -0.5 (F5)-102
1.32u
#EV 2.59%
Sean Zerillo
Sean Zerillo
Last 30d: 148-125-9 (+4.4u)
CIN +150
0.5u
Bet to +133
Matt Trollo
Matt Trollo
Last 30d: 74-82-9 (-9.6u)
Under 8.5-115
0.58u
Not including this in Saturday's breakdown because only FD has this price and I'd want 8.5. Negative run environment, neutral weather, G.Williams approaching 30 K%, both offenses below 95 wRC+ Hm/Rd/v RHP, CLE proj Def 13 FRV, 7th best bullpen estimators L30 days

Reds vs. Guardians Previews & Analysis

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    Super-Strong Sharp Action Saturday

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Prop Odds Comparison

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Line Movement Tracker

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Reds vs. Guardians Public Betting Percentages

Away Logo

Reds

Public

19%

Bets%

81%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Guardians
42-3719-1723-2018-2324-13
Reds
42-3519-2023-1513-1129-24

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Guardians
39-4018-1821-2221-2017-20
Reds
45-31-123-1622-15-115-930-22-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Guardians
41-3819-1722-2122-1919-18
Reds
37-4019-2018-2014-1023-30

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
May 15thCINL 6-7-1.5 LO 7.5CIN -141
May 13thLAAW 4-2-1.5 WU 7CLE -159
May 12thLAAW 3-2-1.5 LU 8.5CLE -139
May 11thLAAW 7-2-1.5 WO 7.5CLE -173
May 10thMINL 4-5-1.5 LO 7.5MIN -162

Guardians vs. Reds Injury Updates

Guardians Injuries

    Reds Injuries

    • Hunter Greene
      SP

      Greene is out with elbow

      Out

    Reds vs. Guardians Box Score
    Reds Player Stats
    Projected
    PITCHERPCIPKER
    Chris Paddack logoRC.Paddack, P78532
    Luis Mey logoRL.Mey, P210.112
    Sam Moll logoLS.Moll, P221.121
    Pierce Johnson logoRP.Johnson, P120.101
    Connor Phillips logoRC.Phillips, P27120
    HITTERSH-ABRHRRBI
    Dane Myers logo1D.Myers, CF1-4111
    Elly De La Cruz logo2E.De La Cruz, SS1-3100
    Sal Stewart logo3S.Stewart, 1B0-2001
    Spencer Steer logo4S.Steer, LF1-4002
    JJ Bleday logo5J.Bleday, DH0-4000
    Matt McLain logo6M.McLain, 2B0-4000
    Blake Dunn logo7B.Dunn, RF2-3100
    Will Benson logo7W.Benson, PH0-1000
    Jose Trevino logo8J.Trevino, C0-1000
    Tyler Stephenson logo8T.Stephenson, PH0-1000
    Tyler Stephenson logo8T.Stephenson, C0-1000
    Ke'Bryan Hayes logo9K.Hayes, 3B0-2100
    Nathaniel Lowe logo9N.Lowe, PH0-1000
    Guardians Player Stats
    Projected
    PITCHERPCIPKER
    Joey Cantillo logoLJ.Cantillo, P87544
    Colin Holderman logoRC.Holderman, P131.210
    Erik Sabrowski logoLE.Sabrowski, P50.110
    Hunter Gaddis logoRH.Gaddis, P14100
    Cade Smith logoRC.Smith, P17120
    HITTERSH-ABRHRRBI
    Daniel Schneemann logo1D.Schneemann, CF0-3000
    Rhys Hoskins logo1R.Hoskins, PH0-0001
    Petey Halpin logo1P.Halpin, CF0-1000
    Jose Ramirez logo2J.Ramirez, 3B2-4100
    Chase DeLauter logo3C.DeLauter, DH0-4000
    Kyle Manzardo logo4K.Manzardo, 1B2-5100
    Travis Bazzana logo5T.Bazzana, 2B1-5000
    Steven Kwan logo6S.Kwan, LF1-3200
    Angel Martinez logo7A.Martinez, RF2-4312
    Austin Hedges logo8A.Hedges, C0-2000
    Brayan Rocchio logo9B.Rocchio, SS2-3002

    Reds vs. Guardians Odds Comparison

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    Reds at Guardians Team Totals

    MatchupOverUnder
    Reds
    37-40
    N/A
    N/A
    Guardians
    41-38
    N/A
    N/A