Reds vs. Guardians Odds & Betting Predictions - May 16, 2026

Reds at Guardians

10:10 pm • CINR

Cincinnati Reds

Cleveland Guardians

pitcher		team	era	w-l
G.Williams			3.74	5-3
C.Paddack			7.63	0-5

MatchupOpenSpreadTotalMoneyline
Reds 23-21	+1.5	+1.5-145	o8-115	+150
Guardians 24-21	u8.5	-1.5+120	u8-105	-180

Saturday 10:10 p.m.

May 16, 2026

Progressive FieldCleveland

71°Fahrenheit

9%Rain

11Wind

Under 8.5-115

0.58u

Not including this in Saturday's breakdown because only FD has this price and I'd want 8.5. Negative run environment, neutral weather, G.Williams approaching 30 K%, both offenses below 95 wRC+ Hm/Rd/v RHP, CLE proj Def 13 FRV, 7th best bullpen estimators L30 days

No props found

MLB Public Betting

Guardians are 3-2 in their last 5 games.
Guardians are 3-2 in their last 5 games against the spread
Guardians are 11-12 in their road games against the spread
The totals have gone OVER in 2 of Guardians' last 5 games
The totals have gone OVER in 9 of Guardians' 22 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	25-20	14-8	11-12	14-11	11-9
Reds	26-18	13-11	13-7	9-6	17-12

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	22-23	9-13	13-10	12-13	10-10
Reds	27-16-1	17-7	10-9-1	10-5	17-11-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	24-21	13-9	11-12	14-11	10-10
Reds	23-21	13-11	10-10	9-6	14-15

date	opponent	score	spread	over/under	moneyline
May 15th	CIN	L 6-7	-1.5 L	O 8	CIN -141
May 13th	LAA	W 4-2	-1.5 W	U 7	CLE -159
May 12th	LAA	W 3-2	-1.5 L	U 8.5	CLE -139
May 11th	LAA	W 7-2	-1.5 W	O 7.5	CLE -173
May 10th	MIN	L 4-5	-1.5 L	O 7.5	MIN -162

Hunter Greene
SP
Greene is out with elbow
Out

See more MLB Injuries

PITCHER		W-L	ERA	WHIP	K/9
RC.Paddack, P		0-5	7.63	1.663	7.92

HITTERS	AVG	OBP	SLG	HR
1W.Benson, RF	.194	.341	.343	2
2E.De La Cruz, SS	.299	.359	.525	10
3S.Stewart, 3B	.244	.328	.470	10
4J.Bleday, LF	.321	.455	.755	6
5S.Steer, 1B	.259	.333	.449	7
6N.Lowe, DH	.244	.330	.512	6
7T.Stephenson, C	.187	.285	.308	3
8T.Friedl, CF	.184	.268	.270	2
9M.McLain, 2B	.214	.320	.344	4

PITCHER		W-L	ERA	WHIP	K/9
RG.Williams, P		5-3	3.74	1.175	10.73

HITTERS	AVG	OBP	SLG	HR
1S.Kwan, LF	.206	.311	.265	1
2C.DeLauter, DH	.294	.376	.503	6
3J.Ramirez, 3B	.207	.340	.366	6
4K.Manzardo, 1B	.203	.286	.288	2
5T.Bazzana, 2B	.222	.407	.311	1
6D.Schneemann, CF	.272	.357	.447	4
7A.Martinez, RF	.260	.300	.473	7
8P.Bailey, C	.000	.000	.000	0
9B.Rocchio, SS	.275	.350	.373	3