White Sox vs. Guardians Odds & Betting Predictions - September 12, 2025
White Sox at Guardians
11:10 pm • CLEGStarting Pitchers
| pitcher | team | era | w-l | |
|---|---|---|---|---|
 |  | 4.25 | 12-11 | |
 |  | 3.54 | 1-6 |
White Sox at Guardians Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
White Sox 11-15 | +1.5-180 | o7.5-110 | +119 | |
Guardians 15-12 | u8 | -1.5+150 | u7.5-108 | -142 |
Progressive FieldCleveland
White Sox vs. Guardians Expert Picks
Allan Lem
Last 30d: 53-42-0 (+1.0u)
CLE -135
0.5u
I actually don’t consider Martin Perez a gas can but project Cleveland for half a run higher and like how the Cleveland bats profile against him.
Wags Wins
Last 30d: 239-263-2 (-8.5u)
Under 7.5-103
1.21u
Payoff Pitch Podcast
Last 30d: 100-136-8 (+15.9u)
T.Bibee u5.5 Ks-145
1u
@cowhitchurch https://myaction.app/RW4DhImIBWb
Picks Office
Last 30d: 199-193-10 (-7.4u)
CWS +135
1u
Brian Bitler
Last 30d: 83-84-0 (-4.1u)
CWS +135
3u
Sean Zerillo
Last 30d: 174-171-13 (-10.7u)
CLE -146
0.5u
Bet to -155
Collin Whitchurch
Last 30d: 93-172-6 (+4.2u)
T.Bibee u5.5 Ks-140
0.7u
White Sox vs. Guardians Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
White Sox vs. Guardians Public Betting Percentages
Betting Trends
- Guardians are 3-2 in their last 5 games.
- Guardians are 3-2 in their last 5 games against the spread
- Guardians are 7-7 in their road games against the spread
- The totals have gone OVER in 4 of Guardians' last 5 games
- The totals have gone OVER in 6 of Guardians' 13 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Guardians vs. White Sox Injury Updates
Guardians Injuries
- Steven KwanLF
Steven Kwan scratched Saturday
Out
White Sox Injuries
- Mike VasilRP
Vasil is out with elbow
Out
- Ky BushSP
Bush is out with elbow
Out
- Brooks BaldwinLF
Baldwin is out with elbow
Out
- Kyle TeelC
Teel is out with hamstring
Out
- Drew ThorpeSP
Thorpe is out with elbow
Out
White Sox vs. Guardians Box Score
White Sox Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
 | 96 | 6.2 | 3 | 3 | |
 | 23 | 1.1 | 0 | 1 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
 | 0-4 | 0 | 0 | 0 |
 | 0-4 | 0 | 0 | 0 |
 | 0-4 | 0 | 0 | 0 |
 | 0-3 | 0 | 0 | 0 |
 | 0-3 | 0 | 0 | 0 |
 | 0-3 | 0 | 0 | 0 |
 | 0-2 | 0 | 0 | 0 |
 | 0-1 | 0 | 0 | 0 |
 | 1-3 | 0 | 0 | 0 |
 | 1-2 | 0 | 0 | 0 |
Guardians Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
 | 103 | 9 | 10 | 0 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
 | 0-3 | 0 | 0 | 0 |
 | 1-3 | 1 | 1 | 1 |
 | 0-4 | 0 | 0 | 0 |
 | 1-3 | 1 | 1 | 1 |
 | 0-3 | 0 | 0 | 0 |
 | 1-3 | 1 | 0 | 0 |
 | 1-2 | 1 | 0 | 0 |
 | 1-1 | 0 | 0 | 1 |
| 1-1 | 0 | 0 | 1 |
 | 0-3 | 0 | 0 | 0 |
 | 1-3 | 0 | 0 | 1 |
White Sox vs. Guardians Odds Comparison
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White Sox at Guardians Team Totals
MatchupOverUnder | ||
|---|---|---|
White Sox 11-15 | N/A | N/A |
Guardians 15-12 | N/A | N/A |