USC vs. Illinois Odds & Betting Predictions - September 27, 2025

USC at Illinois

4:00 pm • FOX

USC Trojans

@

Illinois Fighting Illini

MatchupOpenSpreadTotalMoneyline
USC 4-0	-1.5	-6.5-114	o60.5-112	-250
Illinois 3-1	u56.5	+6.5-106	u60.5-108	+200

location pin

Saturday 4:00 p.m.

September 27, 2025

Memorial Stadium (Champaign, IL)Champaign

thermometer image

74°Fahrenheit

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0%Rain

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2Wind

Under 61.5-115

1u

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NCAAF Public Betting

Illinois are 3-1 in their last 5 games.
Illinois are 3-1 in their last 5 games against the spread
Illinois are 1-1 in their road games against the spread
The totals have gone OVER in 2 of Illinois' last 4 games
The totals have gone OVER in 0 of Illinois' 2 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Illinois	3-1	2-0	1-1	2-0	0-1
USC	2-2	2-1	0-1	2-2	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Illinois	2-2	0-2	2-0	1-1	1-0
USC	3-1	3-0	0-1	3-1	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Illinois	3-1	N/A	N/A	2-0	0-1
USC	4-0	N/A	N/A	4-0	N/A

date	opponent	score	spread	over/under	moneyline
Sep 20th	@IU	L 10-63	+6.5 L	O 51.5	IU +200
Sep 13th	WMU	W 38-0	-27.5 W	U 50.5	ILL -6500
Sep 6th	@DUKE	W 45-19	-2.5 W	O 49	ILL -134
Aug 29th	WIL	W 52-3	-48.5 W	U 62.5	-
Dec 31st	SC	W 21-17	+9.5 W	U 50.5	ILL +280

Total

Passing

1326

YDS

882

81/111

Comps/Atts

73/104

11.95

YPA

8.48

10/0

TDs/INTs

9/1

2/14

Sacks/Yards

16/109

Rushing

1009

Rush Yards

496

143

Attempts

136

7.06

YPC

3.65

15

TDs

9

Turnovers

Fumbles Lost

0

Interceptions

1

Efficiency

23/24 95.8%

Redzone

16/18 88.9%

23/41 0%

3rd Down

17/44 0%

5/6 0%

4th Down

4/4 0%

First Downs

104

Total

75

51

Pass

35

42

Rush

31

11

Penalty

9

Misc

/

Penalties/Yards

/

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MatchupOverUnder
USC 4-0	N/A	N/A
Illinois 3-1	N/A	N/A