USC vs. Illinois Odds & Betting Predictions - September 27, 2025
USC at Illinois
4:00 pm • FOXUSC at Illinois Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
USC 9-4 | -1.5 | -6.5-115 | o62-110 | -250 |
Illinois 9-4 | u56.5 | +6.5-108 | u62-110 | +200 |

Gies Memorial Stadium (Champaign, IL)Champaign
USC vs. Illinois Expert Picks
Sandy Plashkes
Last 30d: 91-92-4 (-9.1u)
USC +120 (Live)
1u
Collin Wilson
Last 30d: 15-10-3 (+5.2u)
USC +3 (Live)-110
0.5u
John Feltman
Last 30d: 65-69-2 (-12.2u)
Over 54 (Live)-118
1.69u
Mjaybrod
Last 30d: 60-69-3 (-9.6u)
USC -3.5 (Live)-108
1u
Easy bet here
VegasIsMyBitch
Last 30d: 23-14-0 (+5.4u)
Over 62-109
0.46u
Jeremiah Rose
Last 30d: 31-23-2 (+12.3u)
ILL +7-115
0.35u
Collin Wilson
Last 30d: 15-10-3 (+5.2u)
ILL +7-115
1u
Coming back live on USC with a slow start
Sandy Plashkes
Last 30d: 91-92-4 (-9.1u)
USC -6.5-115
1.15u
The Degenerates
Last 30d: 105-94-8 (+2.4u)
ILL +6.5-105
1u
John Feltman
Last 30d: 65-69-2 (-12.2u)
Over 60.5-110
4u
Dan Gaspar
Last 30d: 0-0-0 (+0.0u)
K.Feagin u0.5 Recs+140
1u
Babs .
Last 30d: 45-36-0 (+3.6u)
Under 61.5-115
1u
USC vs. Illinois Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
USC vs. Illinois Public Betting Percentages
Betting Trends
- Illinois are 3-2 in their last 5 games.
- Illinois are 3-2 in their last 5 games against the spread
- Illinois are 2-3 in their road games against the spread
- The totals have gone OVER in 2 of Illinois' last 5 games
- The totals have gone OVER in 1 of Illinois' 7 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Team Stats
364
YDS
331
30/43
Comps/Atts
21/27
8.465116279069768
YPA
12.25925925925926
2/1
TDs/INTs
3/0
1/10
Sacks/Yards
1/8
USC vs. Illinois Odds Comparison
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USC at Illinois Team Totals
MatchupOverUnder | ||
|---|---|---|
USC 9-4 | N/A | N/A |
Illinois 9-4 | N/A | N/A |






