Virginia vs. Louisville Odds & Betting Predictions - October 4, 2025
Virginia at Louisville
7:30 pm • ESPN2Virginia at Louisville Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Virginia 10-3 | +7.5 | +6.5-110 | o60-110 | +195 |
 Louisville 8-4 | u59.5 | -6.5-115 | u60-110 | -245 |
L&N Federal Credit Union StadiumLouisville
Virginia vs. Louisville Expert Picks
Mjaybrod
Last 30d: 111-100-2 (+10.5u)
LOU +220 (Live)
0.5u
Fuck!
Collin Wilson
Last 30d: 68-61-1 (-0.7u)
Over 58.5-133
0.67u
Alternate Number at DK
Cam Is Money
Last 30d: 136-114-2 (+10.0u)
LOU o33.5 Team Total-125
1u
Allan Lem
Last 30d: 156-126-2 (+3.8u)
LOU -6.5-110
0.55u
Tailing @Bet_Labs
Sean Zerillo
Last 30d: 81-71-1 (+6.1u)
LOU -6.5-105
0.26u
Bet Labs
Last 30d: 23-18-0 (+2.7u)
LOU -6.5-115
1.73u
Ryan Sura
Last 30d: 5-14-0 (-12.6u)
LOU -6.5-115
1.15u
Brian Bitler
Last 30d: 87-73-1 (+25.9u)
LOU -6.5-110
3u
Vegas Refund
Last 30d: 38-40-1 (-6.0u)
LOU -6.5-110
1.1u
💰🦡 Jake
Last 30d: 97-108-2 (-3.0u)
LOU -6.5-110
1.1u
Mjaybrod
Last 30d: 111-100-2 (+10.5u)
LOU -6.5-110
1u
Red birds take a dookie
Brandon Kravitz
Last 30d: 70-81-3 (+2.5u)
LOU -6.5-115
0.58u
Fading VA after the win of their season.
Boomer Betz
Last 30d: 127-142-3 (-10.5u)
Under 63-110
0.91u
Duck
Last 30d: 192-147-3 (+20.3u)
UVA +7.5-115
1u
Easy call here. Two evenly matched teams. Lou 2x fortunate to get out of Pitt with a w. I like wahoos to compete here.
Babs .
Last 30d: 125-87-0 (+24.7u)
LOU -7-110
1u
Boomer Betz
Last 30d: 127-142-3 (-10.5u)
LOU -5.5-110
1u
POD
Virginia vs. Louisville Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Virginia vs. Louisville Public Betting Percentages
Betting Trends
- Louisville are 3-2 in their last 5 games.
- Louisville are 2-3 in their last 5 games against the spread
- Louisville are 3-1 in their road games against the spread
- The totals have gone OVER in 2 of Louisville' last 5 games
- The totals have gone OVER in 4 of Louisville' 8 last games at home
Matchup History
Against the Spread (ATS) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 4-8 | 1-7 | 3-1 | 2-7 | 2-1 |
| 8-5 | 5-2 | 3-2 | 5-4 | 3-1 |
Over/Under History
| overall | home o/u | away o/u | favorite o/u | underdog o/u | |
|---|---|---|---|---|---|
| 5-7 | 4-4 | 1-3 | 5-4 | 0-3 |
| 5-8 | 4-3 | 1-4 | 3-6 | 2-2 |
Straight-Up (ML) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 8-4 | N/A | N/A | 6-3 | 2-1 |
| 10-3 | N/A | N/A | 7-2 | 3-1 |
Last 5 Matchups
Team Stats
237
Total Yards
383
63
Total Plays
75
3.761904761904762
Yards Per Play
5.1066666666666665
149
YDS
329
19/31
Comps/Atts
34/48
4.806451612903226
YPA
6.854166666666667
1/0
TDs/INTs
2/1
2/20
Sacks/Yards
5/46
7/68
Penalties/Yards
5/60
Virginia vs. Louisville Odds Comparison
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Virginia at Louisville Team Totals
MatchupOverUnder | ||
|---|---|---|
Virginia 10-3 | o26.5-121 | u26.5-109 |
Louisville 8-4 | o33.5-127 | u33.5-103 |