Bruins vs. Sabres Odds & Betting Predictions - April 21, 2026

Bruins at Sabres

11:30 pm • ESPN

Boston Bruins

4

4 - 2

Buffalo Sabres

2

MatchupOpenSpreadTotalMoneyline
Bruins 2-4	+1.5	+1.5-181	o6.5-103	+137
Sabres 4-2	u6	-1.5+151	u6.5-118	-165

location pin

Tuesday 11:30 p.m.

April 21, 2026

KeyBank CenterBuffalo

BUF +135 (Live)

1u

Under 6-105

1.05u

Under 6.5-133

0.75u

BOS +145

$1.45

BOS +155

1.55u

Our NHL System Pick for Bruins vs Sabres
Action Network Staff•
Apr 21, 2026 UTC

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No props found

NHL Public Betting

Sabres are 3-2 in their last 5 games.
Sabres are 3-2 in their last 5 games against the spread
Sabres are 4-1 in their road games against the spread
The totals have gone OVER in 3 of Sabres' last 5 games
The totals have gone OVER in 3 of Sabres' 5 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Sabres	5-5	1-4	4-1	2-4	3-1
Bruins	3-3	0-3	3-0	0-2	3-1

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Sabres	5-5	3-2	2-3	3-3	2-2
Bruins	2-4	1-2	1-2	1-1	1-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Sabres	6-3	N/A	N/A	3-3	3-1
Bruins	2-4	N/A	N/A	0-2	2-2

date	opponent	score	spread	over/under	moneyline
Apr 19th	BOS	W 4-3	-1.5 L	O 6.5	BUF -166
Apr 15th	DAL	L 3-4	+1.5 W	O 6.5	DAL +124
Apr 14th	@CHI	W 5-1	-1.5 W	U 6.5	BUF -219
Apr 9th	CBJ	W 5-0	-1.5 W	U 6.5	BUF -105
Apr 8th	@NYR	W 5-3	-1.5 W	O 6.5	BUF -135

Justin Danforth
RW
Danforth is out for season with knee
Out for Season
Noah Ostlund
C
Ostlund is out with lower body
Out
Jiri Kulich
C
Kulich is out for season with ear
Out for Season

Charlie McAvoy
D
McAvoy is suspended with suspension

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4

Goals

2

8

Assists

4

14

Penalties

14

26

Shots

34

32

Hits

30

36

Faceoffs Won

30

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MatchupOverUnder
Bruins 2-4	N/A	N/A
Sabres 4-2	N/A	N/A