Bears vs. 49ers Odds & Betting Predictions - December 29, 2025

Bears at 49ers

1:20 am • NBC/Peacock

Chicago Bears

San Francisco 49ers

MatchupOpenSpreadTotalMoneyline
Bears 11-4	+3.5	+3.5-118	o51.5-111	+160
49ers 11-4	u46.5	-3.5-102	u51.5-110	-190

Monday 1:20 a.m.

December 29, 2025

Levi's StadiumSanta Clara

53°Fahrenheit

0%Rain

4Wind

Under 26.5 (1H)-105

1.58u

Over 52.5-110

CHI +3.5-110

SF -3.5-105

CHI +3.5-114

$114.00

O.Zaccheaus Anytime TD Scorer Yes+400

0.5u

J.Jennings Anytime TD Scorer Yes+140

0.75u

J.Jennings Anytime TD Scorer Yes+155

0.25u

SF -3-115

1.15u

SF -3-110

1.5u

J.Jennings Anytime TD Scorer Yes+140

0.5u

@ChrisRaybon https://myaction.app/oIyNoZLxmZb

L.Burden Anytime TD Scorer Yes+260

0.5u

@The_Oddsmaker https://myaction.app/oIyNoZLxmZb

J.Tonges Anytime TD Scorer Yes+275

0.5u

@GDAWG5000 https://myaction.app/oIyNoZLxmZb

J.Jennings Anytime TD Scorer Yes+105

0.95u

@ChrisRaybon https://myaction.app/9Vu6o9PHlZb

Over 51.5-110

Over 51-108

2.16u

Early 2U guy. A few times a year u get a 2U square NFL over from me but essentially all Football logic here. Niners D bottom 2 in Success Rate vs Rush, Bears O # 2 in Rush Success Rate. Bears D bottom 5 in EPA/Play if u exclude turnovers. Niners O # 2 in EPA/Play since Purdy’s return. Bears D on the field 39 minutes last week. Over over over. Only concern is high total with 2 more run heavy teams but success rate should be through the roof here… Not sure how there’s any stops assuming Bears dont luckbox their way into multiple redzone fumbles. Would be shocked for any pros to come in on the under here pending weather so would assume this does nothing but go up

CHI +3-108

0.1u

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NFL Public Betting

49ers are 2-3 in their last 5 games.
49ers are 2-3 in their last 5 games against the spread
49ers are 7-2 in their road games against the spread
The totals have gone OVER in 3 of 49ers' last 5 games
The totals have gone OVER in 3 of 49ers' 6 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
49ers	10-5	3-3	7-2	8-2	2-3
Bears	9-5-1	4-2-1	5-3	4-2-1	5-3

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
49ers	9-6	3-3	6-3	6-4	3-2
Bears	7-7-1	2-5	5-2-1	3-4	4-3-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
49ers	11-4	N/A	N/A	9-1	2-3
Bears	11-4	N/A	N/A	6-1	5-3

date	opponent	score	spread	over/under	moneyline
Dec 23rd	@IND	W 48-27	-4.5 W	O 46.5	SF -221
Dec 14th	TEN	W 37-24	-12.5 W	O 44.5	SF -900
Nov 30th	@CLE	W 26-8	-5.5 W	U 35.5	SF -250
Nov 25th	CAR	W 20-9	-7.5 W	U 49	SF -375
Nov 16th	@ARI	W 41-22	-3.5 W	O 48.5	SF -192

George Kittle
TE
Kittle is out with ankle
Out
Brandon Aiyuk
WR
Aiyuk is out with knee
Out
Jacob Cowing
WR
Cowing is out with hamstring
Out

Rome Odunze
WR
Odunze is out with foot
Out

See more NFL Injuries

passing yards
Mac Jones
2151
pyds
passing touchdowns
Brock Purdy
17
ptd
rushing yards
Christian McCaffrey
1039
ryds
rushing touchdowns
Christian McCaffrey
9
rtd

	Starter	2ND	3RD	4TH
QB	Brock Purdy	Mac Jones	Kurtis Rourke
RB	Christian McCaffrey	Isaac Guerendo	Jordan James
WR	Jauan Jennings	Jacob Cowing	Skyy Moore	Junior Bergen
TE	George Kittle	Luke Farrell	Jake Tonges	Brayden Willis
LT	Trent Williams	Spencer Burford
LG	Ben Bartch	Nick Zakelj
C	Jake Brendel	Matt Hennessy	Drake Nugent
RG	Dominick Puni	Connor Colby
RT	Colton McKivitz	Austen Pleasants
LDE	Nick Bosa	Yetur Gross-Matos	Robert Beal	William Bradley-King
RDE	Mykel Williams	Bryce Huff	Sam Okuayinonu
WLB	Dee Winters	Nick Martin	Jalen Graham
MLB	Fred Warner	Luke Gifford	Tatum Bethune	Curtis Robinson
LCB	Renardo Green	Jakob Robinson
SS	Ji'Ayir Brown	Malik Mustapha	Derrick Canteen
FS	Jason Pinnock	Marques Sigle	Siran Neal
RCB	Deommodore Lenoir	Darrell Luter
P	Thomas Morstead
PR	Jacob Cowing	Junior Bergen	Jordan Watkins	Ricky Pearsall
KR	Isaac Guerendo	Junior Bergen
LS	Jon Weeks
LWR	Brandon Aiyuk	Malik Turner
DT	Kevin Givens	Alfred Collins	Sebastian Valdez	Evan Anderson
NB	Upton Stout	Chase Lucas
FB	Kyle Juszczyk
NT	Jordan Elliott	C.J. West	Kalia Davis
RWR	Ricky Pearsall	Jordan Watkins	Malik Turner

Total

Passing

3291

YDS

3741

289/499

Comps/Atts

355/514

6.912

YPA

7.564

24/6

TDs/INTs

30/14

23/158

Sacks/Yards

23/147

Bears

Rushing

49ers

2281

Rush Yards

1564

465

Attempts

435

4.905

YPC

3.595

TDs

Bears

Turnovers

49ers

Fumbles Lost

Interceptions

Bears

Efficiency

49ers

30/51 58.82%

Redzone

38/60 63.33%

87/204 0%

3rd Down

97/194 0%

12/25 0%

4th Down

12/19 0%

Bears

First Downs

49ers

316

Total

338

164

Pass

212

131

Rush

105

Penalty

Bears

Misc

49ers

Penalties/Yards

Possession

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MatchupOverUnder
Bears 11-4	N/A	N/A
49ers 11-4	N/A	N/A

Bears vs. 49ers Odds & Betting Predictions - December 29, 2025

Bears at 49ers

Chicago Bears

San Francisco 49ers

Bears at 49ers Odds

Spread, Total, Moneyline

Bears vs. 49ers Previews & Analysis

An Undeniable Anytime TD Edge for Sunday Night

Koerner & Raybon's Week 17 Spreads & Totals

Koerner's Week 17 Pick'em & Confidence Rankings

Gallant's Touchdown Picks for Bears vs. 49ers

Bears vs. 49ers Props

Prop Projections

Prop Odds Comparison

Line Movement Tracker

Bears vs. 49ers Public Betting Percentages

Bears

Public

49ers

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

49ers vs. Bears Injury Updates

49ers Injuries

Bears Injuries

Bears vs. 49ers Odds Comparison

Bears at 49ers Team Totals