Eagles vs. Vikings Odds & Betting Predictions - October 19, 2025

The Eagles had the 21st pick in the 2020 NFL Draft. Philadelphia badly needed a receiver and took one — TCU's Jalen Reagor. He lasted two seasons with the Eagles and has bounced around the league since. The Vikings had the 22nd pick and also needed a receiver. They took Justin Jefferson. Jefferson was passed over by the Eagles, and now Philadelphia will have to spend all game defending him instead. And defending lead receivers has not gone well for this secondary this season. CeeDee Lamb had seven catches for 110 yards in the opener. Puka Nacua caught 11 for 112. Rookie Emeka Egbuka had 101 yards, and Courtland Sutton caught eight balls for 99. Even Wan'Dale Robinson had 6/84 with Malik Nabers out. Philadelphia's secondary just hasn't come anything close to matching last year's dominance, especially against outside receivers, and that makes this a great spot to invest in Jefferson. It looks like Quinyon Mitchell will give it a go, but he's dealing with a hamstring injury, and Philly's other outside corners have struggled. The other injury news is also a boon for Jefferson: J.J. McCarthy will sit again, leaving Carson Wentz starting against his old team. Jefferson averaged only 3.5 catches for 62.5 yards in his two games with McCarthy, struggling to find the ball, but he's looked his usual self in three Wentz games with 7.3 receptions a game for 108 yards. That's more than double the receptions and 72% more yards, with at least 75 yards in all three. Take Jefferson to go over 75.5 receiving yards (Fanatics), and place part of your bet on 100+ yards at +210 (bet365). He's always a threat for 100, and the Eagles have already allowed four games of 99+ yards to opposing WR1s.

Vikings fans may have PTSD with another big game against Philadelphia, and Carson Wentz will certainly relish an opportunity to face his original team. But it's hard to make the Vikings home underdogs in Minnesota, where they still have one of the better home field advantages in football. In fact, it's hard to argue the Eagles are the better team at all right now the way Philadelphia is playing, which could mean the Vikings should be favored here or even pushing -3. The Eagles are just aggressively mid right now. The offense is stagnant, and Vic Fangio's defense has fallen off in a big way. Philadelphia ranks 14th on offense by DVOA and 18th on defense. Again: average. The Eagles aren't running the football particularly well. They're not making big plays or consistent stops on defense. The passing game has been inconsistent at best and invisible at worst. It's hard to identity what exactly this team is doing well right now. Philadelphia can be grateful for the mini-bye it's coming off of after a Thursday night game last week. The Eagles have been besieged by injuries early but saw DTs Jalen Carter and Jordan Davis, LB Zack Baun, G Landon Dickerson, and CB Quinyon Mitchell all return to practice this week. That's huge news for the Eagles — but it doesn't mean all five will play at 100%, or that they'll make it through the game. Philadelphia's defensive line has struggled in a big way when Carter missed this season, and Mitchell is an extremely important cover man in this game with Justin Jefferson and Jordan Addison on the other side — and a hamstring can always act up again. The Vikings are coming off an actual bye, and they badly needed the time off too. Blake Cashman returns at the center of the defense, a huge add as the green-dot linebacker and focal point of the run defense. That's obviously especially important in this matchup. Minnesota's run defense hasn't been great but is much better with Cashman. Minnesota's offensive line is also getting healthy and should be its best of the season. There's even a chance Philadelphia has the worse blocking in this game for the first time in who knows how long. J.J. McCarthy will miss another week — but that's arguably better for the Vikings in the present. McCarthy has only two career starts, and Wentz has been the better QB this season and makes this passing game much more dangerous against a Philly secondary that's been surprisingly beatable. At the end of the day, the best unit on the field is the Vikings defense — especially the pass defense. Kevin Patullo's offense has been so vanilla and predictable for Philadelphia this season, and now one of the most creative defensive play callers in the league, Brian Flores, had two weeks to prep and scheme for it. Flores typically plays heavy zone and brings a ton of blitz — both things Jalen Hurts has struggled at throughout his career and especially this season. That's just not a good setup for Philadelphia. Trends support home underdogs in the first half coming off the bye. If Minnesota can get off to a good start, the Eagles will have to play on the back foot, an uncomfortable spot against this aggressive Flores defense. This is a great spot to back the Vikings.

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This seems like a great bounce back spot for Saquon Barkley & PHI coming off their mini-bye (TNF). The Eagles will be getting back Jalen Carter this week & both Landon Dickerson & Quinyon Mitchell have been practicing (limited). I’m expecting a better defensive performance from them vs Carson Wentz (or JJ McCarthy) & the Vikings & think they could be playing with a lead (-2 point road favorite) in this game. The Vikings have allowed the 2nd highest rushing play% (49.33%) & 2nd most RB rush attempts this season. They also rank 5th worst in Yards before Contact Allowed per Attempt (2.03). Their pass defense is very good & they blitz a ton, so teams have been going super run heavy against them: Quinshon Judkins 23-110 Kenneth Gainwell 19-99 Bijan Robinson 22-143 Tyler Allgeier 16-76 D’Andre Swift 17-53 The Vikings have allowed the 4th highest YPC (4.77) and 4th highest success rate (56.1%) to zone concept runs too. Saquon has had much more success on these & 69.5% of his attempts are zone concepts. This Eagles team’s biggest struggles lately have been on 3rd downs and a lot of that is due to being in 3rd and long situations opposed to 3rd and short where they are much more efficient (tush pushes). They will want to do everything they can to avoid these situations vs a Brian Flores defense that ranks 1st in blitz% & 6th in pressure%. I think they focus heavily on establishing the run. Jordan Mailata (Eagles Tackle) said this to the media, “If we can establish the run game, that’ll take care of everything…we’ve got to be the aggressor. We’ve got to punch first…it always comes down to execution because execution fuels emotion. We just haven’t been executing. Something we’ve been focusing on, simplifying the game.” Its also worth noting the Eagles have faced this Brian Flores defensive scheme once already and had success. In that game they scored 34 points and had tons of success running the football as D’Andre Swift went for 28 rushes 175 yards & 1 TD. I’ll buy low on Saquon & the Eagles in this spot, as they should lean on the run game early and often.