Astros vs. Guardians Odds & Betting Predictions - June 6, 2025

Astros at Guardians

11:10 pm • CLEG
4 - 2
Starting Pitchers
pitcherteameraw-l
Logan Allen logoL.AllenCleveland Guardians logo4.258-11
Colton Gordon logoC.GordonHouston Astros logo5.346-4

Astros at Guardians Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Astros
0-0
+1.5
-1.5+134
o8-102
-128
Guardians
1-2
u8.5
+1.5-163
u8-118
+110
location pinFriday 11:10 p.m.
June 06, 2025
Progressive FieldCleveland
Astros vs. Guardians Expert Picks
Capper Central
Capper Central
Last 30d: 85-77-1 (-0.0u)
HOU -121
1u
Bet Labs
Bet Labs
Last 30d: 23-23-0 (+1.9u)
Under 8.5-115
1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 88-115-4 (-20.3u)
Over 8.5+104
1u
Picks Office
Picks Office
Last 30d: 218-173-3 (+28.7u)
HOU -105
0.95u
Derek Carty
Derek Carty
Last 30d: 6-7-0 (+0.1u)
Jose Ramirez o0.5 Walks+260
1u
Sean Zerillo
Sean Zerillo
Last 30d: 63-58-1 (+1.6u)
HOU -105 (F5)
0.25u
Small to -120
HOU +105
0.53u
Bet to -104

Astros vs. Guardians Previews & Analysis

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  • +630, +875 Home Run Picks Worth Betting article feature image

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Prop Odds Comparison

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Astros vs. Guardians Public Betting Percentages

Away Logo

Astros

Public

52%

Bets%

48%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Guardians
86-7639-4247-3433-3651-38
Astros
82-8037-4445-3643-6039-18

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Guardians
69-87-637-41-332-46-334-34-134-50-5
Astros
72-83-736-43-236-40-545-56-225-27-5

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Guardians
88-7445-3643-3844-2543-46
Astros
87-7546-3541-4056-4731-26

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jun 5th@NYYL 0-4+1.5 LU 8.5NYY +225
Jun 4th@NYYW 4-0+1.5 WU 9CLE +164
Jun 3rd@NYYL 2-3+1.5 WU 8NYY +166
Jun 1stLAAW 4-2-1.5 WU 8CLE -210
May 31stLAAW 7-5-1.5 WO 8CLE -169

Guardians vs. Astros Injury Updates

Guardians Injuries

    Astros Injuries

    • Hayden Wesneski
      RP

      Wesneski is out with elbow

      Out

    Astros vs. Guardians Box Score
    Astros Player Stats
    Projected
    PITCHERPCIPKER
    Colton Gordon logoLC.Gordon, P75551
    Shawn Dubin logoRS.Dubin, P140.201
    Bryan King logoLB.King, P191.110
    Bryan Abreu logoRB.Abreu, P14110
    Josh Hader logoLJ.Hader, P12120
    HITTERSH-ABRHRRBI
    Jeremy Pena logo1J.Pena, SS3-5100
    Isaac Paredes logo2I.Paredes, 3B1-2100
    Jose Altuve logo3J.Altuve, DH2-5101
    Christian Walker logo4C.Walker, 1B1-4002
    Jake Meyers logo5J.Meyers, CF1-4000
    Victor Caratini logo6V.Caratini, C0-3000
    Mauricio Dubon logo7M.Dubon, LF1-4000
    Brendan Rodgers logo8B.Rodgers, 2B1-3111
    Jacob Melton logo9J.Melton, RF0-4000
    Guardians Player Stats
    Projected
    PITCHERPCIPKER
    Logan Allen logoLL.Allen, P88624
    Matt Festa logoRM.Festa, P22100
    Tim Herrin logoLT.Herrin, P12110
    Nic Enright logoRN.Enright, P21110
    HITTERSH-ABRHRRBI
    Angel Martinez logo1A.Martinez, CF1-4000
    David Fry logo2D.Fry, DH2-3111
    Jose Ramirez logo3J.Ramirez, 3B1-4000
    Carlos Santana logo4C.Santana, 1B0-4000
    Daniel Schneemann logo5D.Schneemann, LF1-4100
    Gabriel Arias logo6G.Arias, SS2-4000
    Nolan Jones logo7N.Jones, RF1-2000
    Jhonkensy Noel logo7J.Noel, PH0-1000
    Jhonkensy Noel logo7J.Noel, RF0-1000
    Will Wilson logo8W.Wilson, 2B1-3001
    Dom Nunez logo9D.Nunez, C0-3000

    Astros vs. Guardians Odds Comparison

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    Astros at Guardians Team Totals

    MatchupOverUnder
    Astros
    0-0
    o4.5+115
    u4.5-146
    Guardians
    1-2
    o3.5-113
    u3.5-115