Brewers vs. Cardinals Odds & Betting Predictions - September 20, 2025

Brewers at Cardinals

11:15 pm • FDSMW

Milwaukee Brewers

45-27

3 - 2

St. Louis Cardinals

40-33

pitcher		team	era	w-l
M.Mikolas			4.84	8-11
C.Patrick			3.54	3-8

MatchupOpenSpreadTotalMoneyline
Brewers 45-27	-1.5	-1.5+114	o8.5-120	-145
Cardinals 40-33	u8.5	+1.5-134	u8.5+100	+121

Saturday 11:15 p.m.

September 20, 2025

Busch StadiumSt. Louis

MIL -140

0.5u

Mikolas with a 4.80 ERA but 5.27 xERA. He did beat Brewers last start but underlying numbers just scream negative regression candidate. On the flip side, Chad Patrick has a 4.03 xERA. Paying a bit of juice here to back the Brewers but a spot I’m willing to do it.

STL +130

Saturday's MLB Best Bets
Action Network Staff•
Sep 20, 2025 UTC

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MLB Public Betting

Cardinals are 2-3 in their last 5 games.
Cardinals are 1-4 in their last 5 games against the spread
Cardinals are 22-13 in their road games against the spread
The totals have gone OVER in 1 of Cardinals' last 5 games
The totals have gone OVER in 17 of Cardinals' 38 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cardinals	44-29	22-16	22-13	9-6	35-22
Brewers	41-31	23-17	18-14	28-22	13-9

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cardinals	31-38-4	17-19-2	14-19-2	5-9-1	25-29-3
Brewers	33-38-1	18-22	15-16-1	25-24-1	8-14

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cardinals	40-33	21-17	19-16	11-4	29-28
Brewers	45-27	25-15	20-12	33-17	12-10

date	opponent	score	spread	over/under	moneyline
Sep 20th	MIL	W 7-1	+1.5 W	O 7.5	-
Sep 17th	CIN	L 2-6	+1.5 L	U 8.5	CIN +102
Sep 16th	CIN	W 3-0	+1.5 W	U 8	STL +105
Sep 15th	CIN	L 6-11	+1.5 L	O 8.5	CIN -113
Sep 14th	@MIL	W 3-2	+1.5 W	U 8.5	STL +160

Akil Baddoo
LF
Baddoo is out with quad
Out
Quinn Priester
SP
Priester is out with wrist
Out
Drew Rom
SP
Rom is out with biceps
Out

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PITCHER	PC	IP	K	ER
RC.Patrick, P	56	4.1	3	2
LA.Ashby, P	39	2.2	1	0
RA.Uribe, P	17	1	2	0
LJ.Koenig, P	16	2	1	0

HITTERS	H-AB	R	RBI
1S.Frelick, RF	1-5	0	0
2J.Chourio, CF	1-5	1	0
2J.Chourio, LF	1-5	1	0
3C.Yelich, DH	0-5	0	0
4W.Contreras, C	1-3	0	0
4D.Jansen, C	0-1	0	0
5B.Turang, 2B	1-5	0	1
6C.Durbin, 3B	1-5	1	0
7J.Bauers, LF	1-4	1	0
7B.Perkins, CF	0-0	0	0
8A.Vaughn, 1B	1-1	0	1
8A.Monasterio, PR	0-0	0	0
8A.Monasterio, 1B	0-0	0	0
9J.Ortiz, SS	2-4	0	1

PITCHER	PC	IP	K	ER
RM.Mikolas, P	95	5	3	2
RK.Leahy, P	24	2	1	0
RR.O'Brien, P	19	1.1	1	0
LJ.Romero, P	17	1.2	0	0

HITTERS	H-AB	R	RBI
1B.Donovan, 2B	1-5	0	1
2I.Herrera, DH	1-4	1	0
3A.Burleson, LF	1-4	0	0
3A.Burleson, 1B	1-4	0	0
4N.Arenado, 3B	2-4	0	1
5T.Saggese, SS	1-4	0	0
6N.Gorman, 1B	0-4	0	0
6N.Church, LF	0-0	0	0
6N.Church, CF	0-0	0	0
7P.Pages, C	1-4	1	0
8J.Walker, RF	2-3	0	0
9V.Scott, CF	0-1	0	0
9Y.Pozo, PH	0-1	0	0
9L.Nootbaar, LF	0-0	0	0