Cardinals vs. Marlins Odds & Betting Predictions - April 21, 2026

Cardinals at Marlins

10:40 pm • MIAM

St. Louis Cardinals

42-35

5 - 3

Miami Marlins

41-39

pitcher		team	era	w-l
C.Paddack			6.05	0-2
D.May			4.30	5-6

MatchupOpenSpreadTotalMoneyline
Cardinals 42-35	+1.5	-1.5+153	o8.5-120	+101
Marlins 41-39	u8.5	+1.5-186	u8.5-101	-123

Tuesday 10:40 p.m.

April 21, 2026

loanDepot parkMiami

Over 8.5-105

1.05u

Under 8.5+100

0.5u

STL +100

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X.Edwards o0.5 SB+575

0.2u

Targetting Dustin May with a couple LHB with speed. He’s allowed a 1.58 WHIP in 2025 & 1.95 in 2026 vs LHB. He allowed 15 SBs on 21 Att since last season & continues to allow big leads & jumps to baserunners. I’m expecting Miami to be aggressive on the bases tonight.

J.Marsee o0.5 SB+475

0.25u

D.May o16.5 Outs-106

1.06u

D.May u2.5 Earned Runs-125

STL -102

STL -110 (F5)

Under 8.5-103

0.5u

Bet to -110

J.Walker o0.5 HR+460

@gneiffer07 ⭐️⭐️⭐️ https://myaction.app/IPqH1gLpw2b

STL +100

0.5u

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No props found

MLB Public Betting

Marlins are 4-1 in their last 5 games.
Marlins are 3-2 in their last 5 games against the spread
Marlins are 17-19 in their road games against the spread
The totals have gone OVER in 2 of Marlins' last 5 games
The totals have gone OVER in 20 of Marlins' 44 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Marlins	38-42	21-23	17-19	20-20	18-22
Cardinals	45-32	22-18	23-14	10-9	35-22

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Marlins	44-33-3	20-24	24-9-3	18-22	26-11-3
Cardinals	33-40-4	17-21-2	16-19-2	7-11-1	25-29-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Marlins	41-39	27-17	14-22	27-13	14-26
Cardinals	42-35	22-18	20-17	13-6	29-28

date	opponent	score	spread	over/under	moneyline
Apr 20th	STL	W 5-3	-1.5 W	U 8.5	MIA -138
Apr 19th	MIL	W 5-3	+1.5 W	O 7.5	MIA -115
Apr 18th	MIL	L 2-5	+1.5 L	U 7.5	MIL -119
Apr 17th	MIL	L 5-7	-	O 8	MIL -115
Apr 15th	@ATL	L 3-6	+1.5 L	U 9	ATL +138

Maximo Acosta
SS
Acosta is out with oblique
Out
Adam Mazur
SP
Mazur is out with elbow
Out

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PITCHER	PC	IP	K	ER
RD.May, P	97	5.1	5	1
LJ.Bruihl, P	27	1.2	0	0
RR.Stanek, P	32	0.2	2	2
RG.Soriano, P	6	0.1	1	0
RR.O'Brien, P	17	1	1	0

HITTERS	H-AB	R	HR	RBI
1J.Wetherholt, 2B	1-4	2	0	0
2I.Herrera, DH	2-5	0	0	0
3A.Burleson, 1B	2-4	1	0	2
4J.Walker, RF	0-4	0	0	0
5N.Gorman, 3B	1-4	0	0	1
6M.Winn, SS	2-4	1	0	0
7N.Church, LF	2-4	1	1	2
8P.Pages, C	0-4	0	0	0
9V.Scott, CF	0-3	0	0	0

PITCHER	PC	IP	K	ER
RC.Paddack, P	90	4.2	7	5
LJ.King, P	19	1.1	2	0
RT.Phillips, P	40	3	3	0

HITTERS	H-AB	R	HR	RBI
1J.Marsee, CF	3-4	1	1	1
2K.Stowers, LF	0-4	0	0	0
2K.Stowers, RF	0-4	0	0	0
3O.Lopez, SS	0-5	0	0	0
4X.Edwards, 2B	2-4	1	0	0
5L.Hicks, C	0-3	1	0	0
6A.Ramirez, DH	0-4	0	0	0
7O.Caissie, RF	0-2	0	0	0
7A.Slater, PH	0-1	0	0	0
7J.Sanoja, 3B	0-0	0	0	0
8G.Pauley, 3B	1-2	0	0	0
8H.Hernandez, PH	1-1	0	0	2
8H.Hernandez, LF	1-1	0	0	2
9C.Norby, 1B	1-4	0	0	0