Giants vs. Padres Odds & Betting Predictions - August 21, 2025

Giants at Padres

8:10 pm • SDPA

San Francisco Giants

61-67

4 - 8

San Diego Padres

72-56

pitcher		team	era	w-l
D.Cease			4.71	6-11
J.Verlander			4.64	1-10

MatchupOpenSpreadTotalMoneyline
Giants 61-67	+1.5	+1.5-134	o8-111	+161
Padres 72-56	u8	-1.5+109	u8-111	-193

Thursday 8:10 p.m.

August 21, 2025

PETCO ParkSan Diego

SF +164

0.5u

SD -1.5+130

1.3u

Over 7.5-120

0.83u

SD -1.5+115

2.3u

Under 0.5 (1st Inn)-120

Under 8-118

0.59u

Under is popping in the Action models so I’ll bite

Under 8-110

0.55u

Bet to -115

SD -150 (F5)

0.25u

Small to -165

Giants vs Padres: Thursday Afternoon Over/Under Pick
Action Network Staff•
Aug 21, 2025 UTC

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No props found

MLB Public Betting

Padres are 3-2 in their last 5 games.
Padres are 4-1 in their last 5 games against the spread
Padres are 36-30 in their road games against the spread
The totals have gone OVER in 3 of Padres' last 5 games
The totals have gone OVER in 27 of Padres' 62 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Padres	71-57	35-27	36-30	33-37	37-20
Giants	53-75	24-39	29-36	25-51	27-23

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Padres	53-71-4	27-34-1	26-37-3	36-32-2	17-38-2
Giants	58-66-4	24-38-1	34-28-3	26-49-1	30-17-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Padres	72-56	41-21	31-35	43-27	28-29
Giants	61-67	30-33	31-34	38-38	22-28

date	opponent	score	spread	over/under	moneyline
Aug 21st	SF	W 8-1	-1.5 W	O 8	SD -140
Aug 20th	SF	W 5-1	-1.5 W	U 8	SD -189
Aug 19th	SF	L 3-4	-1.5 L	U 7.5	SF -149
Aug 17th	@LAD	L 4-5	+1.5 W	O 8.5	LAD +120
Aug 17th	@LAD	L 0-6	+1.5 L	U 7.5	LAD +103

Tom Murphy
C
Murphy is out with back
Out

Joe Musgrove
SP
Musgrove is out for season with elbow
Out for Season
Michael King
SP
Michael King (shoulder) has been scratched Saturday. Sean Reynolds will start for the Padres.
Out

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PITCHER	PC	IP	K	ER
RJ.Verlander, P	91	4.1	4	7
LM.Gage, P	17	0.2	1	1
RJ.Peguero, P	32	2	1	0
RS.Bivens, P	10	1	1	0

HITTERS	H-AB	R	HR	RBI
1J.Lee, CF	1-3	0	0	0
2H.Ramos, LF	0-4	0	0	0
3R.Devers, DH	1-4	1	1	1
4W.Adames, SS	1-2	1	1	1
5D.Smith, 1B	0-3	0	0	0
5W.Flores, PH	0-1	0	0	0
5W.Flores, 1B	0-1	0	0	0
6C.Schmitt, 3B	1-3	0	0	0
7C.Koss, 2B	0-4	0	0	0
8L.Matos, RF	2-4	1	0	0
9A.Knizner, C	1-3	1	0	1
9P.Bailey, PH	0-1	0	0	0

PITCHER	PC	IP	K	ER
RD.Cease, P	95	5	7	4
RJ.Estrada, P	24	1.1	1	0
LA.Morejon, P	14	1	0	0
RM.Miller, P	5	0.2	1	0
RR.Suarez, P	13	1	2	0

HITTERS	H-AB	R	RBI
1F.Tatis, RF	2-5	2	0
2L.Arraez, 1B	2-4	1	0
3M.Machado, 3B	2-4	1	3
4R.O'Hearn, DH	0-2	1	0
5X.Bogaerts, SS	1-3	0	2
6G.Sheets, LF	0-3	0	0
6B.Johnson, CF	1-1	0	0
7R.Laureano, CF	2-4	1	1
7R.Laureano, LF	2-4	1	1
8J.Cronenworth, 2B	0-3	1	0
9F.Fermin, C	1-4	1	0