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Kentucky vs. Louisville Odds & Betting Predictions - November 12, 2025

Kentucky at Louisville

1:00 am • ESPN

Kentucky Wildcats

17-10
88
88 - 96

Louisville Cardinals

20-7
96

Kentucky at Louisville Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Kentucky
17-10
+4.5
+6-107
o173.5-111
+196
Louisville
20-7
u168.5
-6-112
u173.5-109
-245
location pinWednesday 1:00 a.m.
November 12, 2025
KFC Yum! CenterLouisville
Kentucky vs. Louisville Expert Picks
JMann
JMann
Last 30d: 39-34-0 (+2.7u)
M.Brown o5.5 Ast-106
1u
Picks Office
Picks Office
Last 30d: 196-136-3 (+45.8u)
Under 174.5-110
2u
X: PicksOffice
Tickle the Twine
Tickle the Twine
Last 30d: 54-46-0 (+3.0u)
Under 174.5-110
1u
Sandy Plashkes
Sandy Plashkes
Last 30d: 86-75-7 (+1.8u)
LOU -6.5-110
1u
@Mjaybrxd tail
Mjaybrod
Mjaybrod
Last 30d: 61-43-0 (+19.5u)
LOU -6.5-105
0.95u
CBB POD
LOU -6.5-105
0.95u
Number is huge for a reason
Ryan Minion
Ryan Minion
Last 30d: 172-203-3 (+36.6u)
M.Brown o1.5 3pt M-120
$1.00
M.Brown o23.5 Pts+Rebs+Ast-115
$1.00
FTN Fantasy
FTN Fantasy
Last 30d: 136-146-2 (-26.2u)
LOU -3.5-115
0.87u
Ryan Minion
Ryan Minion
Last 30d: 172-203-3 (+36.6u)
LOU -160
$1.00

Kentucky vs. Louisville Previews & Analysis

  • Kentucky vs Louisville: How to Bet This Juicy Rivalry Duel article feature image

    Kentucky vs Louisville: How to Bet This Juicy Rivalry Duel

    Dead President Picks•
    Nov 11, 2025 UTC
  • Our Staff's Best Bets for Louisville vs Kentucky article feature image

    Our Staff's Best Bets for Louisville vs Kentucky

    Action Network Staff•
    Nov 11, 2025 UTC
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Prop Odds Comparison

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No props found

Line Movement Tracker

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Kentucky vs. Louisville Public Betting Percentages

Away Logo

Kentucky

Public

Home Logo

Louisville

31%

Bets%

69%

Money%

NCAAB Public Betting Right Arrow

Betting Trends

  • Louisville are 4-1 in their last 5 games.
  • Louisville are 2-3 in their last 5 games against the spread
  • Louisville are 5-6 in their road games against the spread
  • The totals have gone OVER in 3 of Louisville' last 5 games
  • The totals have gone OVER in 5 of Louisville' 16 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Louisville		13-148-85-610-90-3
Kentucky		13-149-104-44-75-4

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Louisville		10-175-115-68-110-3
Kentucky		13-149-104-44-74-5

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Louisville		20-7N/AN/A15-40-3
Kentucky		17-10N/AN/A7-43-6

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 7thJKSTW 106-70-38.5 LO 165.5-
Nov 4thSCSTW 104-45-36.5 WU 159.5-
Mar 20thCREIL 75-89-3 LO 146.5CREI -167
Mar 16th@DUKEL 62-73+6.5 LU 148.5DUKE +215
Mar 15thCLEMW 76-73+2.5 WO 141.5LOU +120

Kentucky vs. Louisville Injury Updates

Kentucky Injuries

  • Jaland Lowe
    G

    Lowe is out for season with arm

    Out for Season

  • Jayden Quaintance
    F

    Quaintance is out with knee

    Out

  • Kam Williams
    G

    Williams is out with foot

    Out

Louisville Injuries

    See more NCAAB Injuries Right Arrow
    Team Stats

    32-68 (47%)
    Field Goals
    31-69 (45%)
    12-16 (75%)
    Free Throws
    21-31 (68%)
    12-34 (35%)
    3P
    13-40 (33%)
    40
    Rebounds
    37
    14
    Assists
    20
    14
    Turnovers
    6
    4
    Steals
    11
    3
    Blocks
    3
    21
    Fouls
    19

    Kentucky vs. Louisville Odds Comparison

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    Kentucky at Louisville Team Totals

    MatchupOverUnder
    Kentucky
    17-10
    N/A
    N/A
    Louisville
    20-7
    N/A
    N/A