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Kentucky vs. Louisville Odds & Betting Predictions - November 12, 2025

Kentucky at Louisville

1:00 am • ESPN

Kentucky Wildcats

8-4
88
88 - 96

Louisville Cardinals

10-2
96

Kentucky at Louisville Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Kentucky
8-4
+4.5
+6-107
o173.5-111
+196
Louisville
10-2
u168.5
-6-112
u173.5-109
-245
location pinWednesday 1:00 a.m.
November 12, 2025
KFC Yum! CenterLouisville
Kentucky vs. Louisville Expert Picks
Picks Office
Picks Office
Last 30d: 188-132-1 (+37.1u)
Under 174.5-110
2u
X: PicksOffice
Tickle the Twine
Tickle the Twine
Last 30d: 31-21-0 (+6.8u)
Under 174.5-110
1u
Sandy Plashkes
Sandy Plashkes
Last 30d: 102-135-1 (-47.7u)
LOU -6.5-110
1u
@Mjaybrxd tail
Mjaybrod
Mjaybrod
Last 30d: 86-76-2 (+8.4u)
LOU -6.5-105
0.95u
CBB POD
LOU -6.5-105
0.95u
Number is huge for a reason
FTN Fantasy
FTN Fantasy
Last 30d: 80-106-2 (-35.0u)
LOU -3.5-115
0.87u

Kentucky vs. Louisville Previews & Analysis

  • Kentucky vs Louisville: How to Bet This Juicy Rivalry Duel article feature image

    Kentucky vs Louisville: How to Bet This Juicy Rivalry Duel

    Dead President Picks•
    Nov 11, 2025 UTC
  • Our Staff's Best Bets for Louisville vs Kentucky article feature image

    Our Staff's Best Bets for Louisville vs Kentucky

    Action Network Staff•
    Nov 11, 2025 UTC
See more NCAAB Coverage Right Arrow

Prop Odds Comparison

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No props found

Line Movement Tracker

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Kentucky vs. Louisville Public Betting Percentages

Away Logo

Kentucky

Public

Home Logo

Louisville

31%

Bets%

69%

Money%

NCAAB Public Betting Right Arrow

Betting Trends

  • Louisville are 3-2 in their last 5 games.
  • Louisville are 3-2 in their last 5 games against the spread
  • Louisville are 2-2 in their road games against the spread
  • The totals have gone OVER in 3 of Louisville' last 5 games
  • The totals have gone OVER in 4 of Louisville' 8 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Louisville		8-46-22-25-10-1
Kentucky		6-66-50-11-21-2

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Louisville		6-64-42-24-20-1
Kentucky		5-74-71-00-31-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Louisville		10-2N/AN/A5-10-1
Kentucky		8-4N/AN/A1-21-2

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 7thJKSTW 106-70-38.5 LO 165.5-
Nov 4thSCSTW 104-45-36.5 WU 159.5-
Mar 20thCREIL 75-89-3 LO 146.5CREI -167
Mar 16th@DUKEL 62-73+6.5 LU 148.5DUKE +215
Mar 15thCLEMW 76-73+2.5 WO 141.5LOU +120

Kentucky vs. Louisville Injury Updates

Kentucky Injuries

  • Jayden Quaintance
    F

    Quaintance is questionable with knee

    Questionable

Louisville Injuries

    See more NCAAB Injuries Right Arrow
    Team Stats

    32-68 (47%)
    Field Goals
    31-69 (45%)
    12-16 (75%)
    Free Throws
    21-31 (68%)
    12-34 (35%)
    3P
    13-40 (33%)
    40
    Rebounds
    37
    14
    Assists
    20
    14
    Turnovers
    6
    4
    Steals
    11
    3
    Blocks
    3
    21
    Fouls
    19

    Kentucky vs. Louisville Odds Comparison

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    Kentucky at Louisville Team Totals

    MatchupOverUnder
    Kentucky
    8-4
    o83.5-120
    u83.5-110
    Louisville
    10-2
    o90.5-115
    u90.5-115