Louisville vs. Michigan St Odds & Betting Predictions - March 21, 2026

Louisville at Michigan St

6:48 pm • CBS

Louisville Cardinals

23-10

30 - 36

Michigan State Spartans

25-7

MatchupOpenSpreadTotalMoneyline
Louisville 23-10	+3.5	+5.5-111	o151.5-110	+200
Michigan St 25-7	u150.5	-5.5-109	u151.5-110	-245

Saturday 6:48 p.m.

March 21, 2026

KeyBank CenterBuffalo

LOU +9.5 (Live)-115

0.58u

LOU +9.5 (Live)-110

0.15u

Good time to get in. 55-15 3P% after Cowell foul trouble. 7+ good

Under 71 (1H)-105

$105.00

Supposed to be to win $50

R.Conwell o19.5 Pts-108

1.08u

@sushibet

LOU +5.5-115

0.58u

Tailing @The_Oddsmaker

LOU +5.5-110

1.1u

LOU +5.5-115

0.58u

#Tailing @The_Oddsmaker

Under 152.5-115

1.25u

MSU -4.5-110

LOU +5.5-115

0.58u

LOU +5.5-110

Gotta do it

LOU +4.5-105

Under 152-110

1.1u

R.Conwell o19.5 Pts+100

LOU +3.5+117

MSU -2.5 (1H)-110

2.2u

LOU +5-110

0.55u

MSU -4.5-110

1.5u

Under 151.5-110

MSU -4.5-110

Under 151.5-110

MSU -4-110

0.55u

MSU -4.5-110

MSU -4.5-105

0.53u

MSU -178

0.8u

LOU +170

0.29u

LOU +4.5-110

0.55u

LOU +170

0.4u

Giffen Guide to March Madness: https://www.actionnetwork.com/ncaab/nick-giffens-moneyline-rollover-picks-2026-guide-march-madness

Louisville vs Michigan State: See You on the Glass
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Mar 21, 2026 UTC
Model-Based Total Highlights Our Saturday NCAA Tourney Best Bets
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McGrath's Projected Scores for Every NCAA Tournament Second-Round Matchup
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Systems, Projections Flag 3 Sweet Edges
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See more NCAAB Coverage

No props found

NCAAB Public Betting

Michigan St are 3-2 in their last 5 games.
Michigan St are 3-2 in their last 5 games against the spread
Michigan St are 7-4 in their road games against the spread
The totals have gone OVER in 4 of Michigan St' last 5 games
The totals have gone OVER in 9 of Michigan St' 21 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Michigan St	16-16	9-12	7-4	12-13	4-2
Louisville	15-18	9-9	6-9	11-13	1-3

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Michigan St	15-17	9-12	6-5	12-13	3-3
Louisville	12-21	5-13	7-8	9-15	1-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Michigan St	25-7	N/A	N/A	22-3	2-4
Louisville	23-10	N/A	N/A	17-7	1-3

date	opponent	score	spread	over/under	moneyline
Mar 19th	NDSU	W 92-67	-16.5 W	O 144.5	MSU -1650
Mar 14th	UCLA	L 84-88	-5.5 L	O 141.5	UCLA -235
Mar 8th	@MICH	L 80-90	+10.5 W	O 152.5	MICH +412
Mar 6th	RUTG	W 91-87	-19.5 L	O 142.5	MSU -3743
Mar 1st	@IND	W 77-64	-3 W	U 144.5	MSU -170

Mikel Brown
G
Brown is out with back
Out

Kaleb Glenn
F
Glenn is out for season with knee
Out for Season
Divine Ugochukwu
G
Ugochukwu is out for season with foot
Out for Season

See more NCAAB Injuries

Louisville

Michigan St

12-32 (38%)

Field Goals

13-27 (48%)

2-2 (100%)

Free Throws

3-3 (100%)

4-17 (24%)

7-13 (54%)

Rebounds

Assists

Turnovers

Steals

Blocks

Fouls

Could not load odds

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MatchupOverUnder
Louisville 23-10	N/A	N/A
Michigan St 25-7	N/A	N/A

Louisville vs. Michigan St Odds & Betting Predictions - March 21, 2026

Louisville at Michigan St

Louisville Cardinals

Michigan State Spartans

Louisville at Michigan St Odds

Spread, Total, Moneyline

Louisville vs. Michigan St Previews & Analysis

Louisville vs Michigan State: See You on the Glass

Model-Based Total Highlights Our Saturday NCAA Tourney Best Bets

McGrath's Projected Scores for Every NCAA Tournament Second-Round Matchup

Systems, Projections Flag 3 Sweet Edges

Prop Odds Comparison

Line Movement Tracker

Louisville vs. Michigan St Public Betting Percentages

Louisville

Public

Michigan St

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Louisville vs. Michigan St Injury Updates

Louisville Injuries

Michigan St Injuries

Louisville vs. Michigan St Odds Comparison

Louisville at Michigan St Team Totals