Brewers vs. Cubs Odds & Betting Predictions - August 21, 2025

Brewers at Cubs

6:20 pm • FDSWI
4 - 1
Starting Pitchers
pitcherteameraw-l
Shota Imanaga logoS.ImanagaChicago Cubs logo3.038-6
Quinn Priester logoQ.PriesterMilwaukee Brewers logo3.4411-2

Brewers at Cubs Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Brewers
80-48
+1.5
+1.5-199
o6.5-120
+118
Cubs
73-55
u7
-1.5+162
u6.5-102
-139
location pinThursday 6:20 p.m.
August 21, 2025
Wrigley FieldChicago
Brewers vs. Cubs Expert Picks
Sir Lockselot
Sir Lockselot
Last 30d: 29-65-0 (-46.0u)
MIL +118
2.36u
🔑 Brewers ML +118 (FanDuel) 2u I know I have been fading them but they are due for a get back. Perfect spot here imo. I know Shota has been money but their offense is still struggling I think brewers can get to him early and Priester take it home on the mound. Great value for the best record in baseball…
Bet Labs
Bet Labs
Last 30d: 11-15-1 (-1.2u)
MIL +115
1u
Picks Office
Picks Office
Last 30d: 89-78-3 (+13.8u)
Under 7-120
0.83u
Lines at Lunch
Lines at Lunch
Last 30d: 47-52-2 (-8.8u)
MIL +113
0.99u
Over 6.5-120
1.2u
Brian Bitler
Brian Bitler
Last 30d: 78-75-0 (+3.8u)
CHC -130
3u
Moneyline Hacks
Moneyline Hacks
Last 30d: 83-74-3 (+23.3u)
Under 7-110
0.91u
🚨Free analysis & VIP Picks can be found on our Discord. Link: https://discord.gg/A8v49URQaG 🎙️Fade the Noise PODCAST - Subscribe!✅ https://www.youtube.com/@FadetheNoise Link to VIP (Copy &Paste): https://linktr.ee/moneylinehacks%F0%9F%94%A560% OFF with promo code: Hacks60
Sean Zerillo
Sean Zerillo
Last 30d: 155-174-4 (-1.8u)
Under 7-110
0.5u
Bet to -115

Brewers vs. Cubs Previews & Analysis

  • Thursday's MLB Best Bets article feature image

    Thursday's MLB Best Bets

    Action Network Staff
    Aug 21, 2025 UTC
  • Zerillo's Opening Pitch for Thursday article feature image

    Zerillo's Opening Pitch for Thursday

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    Aug 21, 2025 UTC
  • Brewers vs Cubs: Best Bet for Thursday Afternoon article feature image

    Brewers vs Cubs: Best Bet for Thursday Afternoon

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Prop Odds Comparison

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Line Movement Tracker

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Brewers vs. Cubs Public Betting Percentages

Away Logo

Brewers

Public

68%

Bets%

32%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cubs
61-6731-3530-3244-4617-21
Brewers
75-5333-2942-2434-3340-20

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cubs
59-62-730-32-429-30-339-46-520-16-2
Brewers
60-65-328-33-132-32-235-31-125-33-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cubs
73-5541-2532-3057-3316-22
Brewers
80-4842-2038-2846-2133-27

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 21stMILW 4-3+1.5 WO 6.5CHC +100
Aug 20thMILW 4-1+1.5 WU 6.5CHC +102
Aug 19thMILW 6-4-1.5 WO 7CHC -158
Aug 18thMILL 0-7+1.5 LU 8MIL -115
Aug 17thPITW 4-3-1.5 LU 7CHC -198

Brewers vs. Cubs Injury Updates

Brewers Injuries

  • Jordan Montgomery
    SP

    Montgomery is out for season with elbow

    Out for Season

  • Rhys Hoskins
    1B

    Hoskins is out with thumb

    Out

  • Easton McGee
    SP

    McGee is out with arm

    Out

  • Garrett Mitchell
    CF

    Mitchell is out with oblique

    Out

  • Aaron Ashby
    RP

    Ashby is out with oblique

    Out

  • Robert Gasser
    SP

    Gasser is out with elbow

    Out

Cubs Injuries

  • Jameson Taillon
    SP

    Taillon is out with calf

    Out

  • Michael Soroka
    SP

    Soroka is out with shoulder

    Out

  • Justin Steele
    SP

    Steele is out for season with elbow

    Out for Season

Brewers vs. Cubs Box Score
Brewers Player Stats
Projected
PITCHERPCIPKER
Quinn Priester logoRQ.Priester, P954.141
Nick Mears logoRN.Mears, P40.200
Grant Anderson logoRG.Anderson, P16110
Jared Koenig logoLJ.Koenig, P11110
Abner Uribe logoRA.Uribe, P27110
Trevor Megill logoRT.Megill, P19110
HITTERSH-ABRHRRBI
Sal Frelick logo1S.Frelick, RF2-4100
Isaac Collins logo2I.Collins, LF1-4002
William Contreras logo3W.Contreras, C0-3000
Christian Yelich logo4C.Yelich, DH0-3100
Andrew Vaughn logo5A.Vaughn, 1B0-3000
Caleb Durbin logo6C.Durbin, 3B0-4000
Brice Turang logo7B.Turang, 2B2-4112
Brandon Lockridge logo8B.Lockridge, CF0-2000
Blake Perkins logo8B.Perkins, PH0-2000
Blake Perkins logo8B.Perkins, CF0-2000
Joey Ortiz logo9J.Ortiz, SS1-2000
Andruw Monasterio logo9A.Monasterio, SS1-1100
Cubs Player Stats
Projected
PITCHERPCIPKER
Shota Imanaga logoLS.Imanaga, P98752
Ryan Brasier logoRR.Brasier, P23112
Drew Pomeranz logoLD.Pomeranz, P17110
HITTERSH-ABRHRRBI
Michael Busch logo1M.Busch, 1B1-4000
Kyle Tucker logo2K.Tucker, RF0-4000
Seiya Suzuki logo3S.Suzuki, DH0-4000
Pete Crow-Armstrong logo4P.Crow-Armstrong, CF0-2001
Ian Happ logo5I.Happ, LF1-2000
Nico Hoerner logo6N.Hoerner, 2B1-4000
Nico Hoerner logo6N.Hoerner, SS1-4000
Willi Castro logo7W.Castro, 3B1-3000
Willi Castro logo7W.Castro, 2B1-3000
Dansby Swanson logo8D.Swanson, SS0-2000
Owen Caissie logo8O.Caissie, PH0-1000
Matt Shaw logo8M.Shaw, 3B0-0000
Reese McGuire logo9R.McGuire, C0-2100
Carson Kelly logo9C.Kelly, PH1-1000

Brewers vs. Cubs Odds Comparison

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Brewers at Cubs Team Totals

MatchupOverUnder
Brewers
80-48
o2.5-149
u2.5+118
Cubs
73-55
o3.5+100
u3.5-129