Cubs vs. Pirates Odds & Betting Predictions - September 17, 2025

Cubs at Pirates

4:35 pm • MLB Network
4 - 0

Cubs at Pirates Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Cubs
87-64
-1.5
-1.5+117
o7.5-116
-145
Pirates
65-87
u8
+1.5-141
u7.5-105
+121
location pinWednesday 4:35 p.m.
September 17, 2025
PNC ParkPittsburgh
Cubs vs. Pirates Expert Picks
Capper Central
Capper Central
Last 30d: 101-64-0 (+26.9u)
Under 8-118
1.18u
Picks Office
Picks Office
Last 30d: 67-85-5 (-19.2u)
PIT +140
1u
Allan Lem
Allan Lem
Last 30d: 93-95-9 (-7.6u)
Under 8-118
1.18u
Austin Pendergrass
Austin Pendergrass
Last 30d: 62-46-0 (+1.2u)
Under 8.5-148
0.5u
Cam Is Money
Cam Is Money
Last 30d: 46-61-0 (-14.0u)
PIT +123
1u
Lines at Lunch
Lines at Lunch
Last 30d: 96-90-3 (+1.3u)
Under 8-120
1.2u
Ryan Sura
Ryan Sura
Last 30d: 69-74-3 (-4.6u)
Under 8-120
1.2u
Lines at Lunch
Lines at Lunch
Last 30d: 96-90-3 (+1.3u)
CHC -141
1.41u
Sean Zerillo
Sean Zerillo
Last 30d: 172-183-5 (-2.0u)
PIT +140
0.5u
Bet to +130
Moneyline Hacks
Moneyline Hacks
Last 30d: 102-123-5 (+39.4u)
CHC -154
2u
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Prop Odds Comparison

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Line Movement Tracker

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Cubs vs. Pirates Public Betting Percentages

Away Logo

Cubs

Public

82%

Bets%

18%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Pirates
82-7045-3237-3818-2662-43
Cubs
71-8035-4036-4050-5820-22

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Pirates
58-86-831-41-527-45-316-26-240-59-6
Cubs
67-75-935-35-532-40-446-55-721-19-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Pirates
65-8742-3523-5221-2343-62
Cubs
87-6446-2941-3568-4018-24

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 16thCHCL 1-4-1.5 LU 6.5CHC -131
Sep 15thCHCL 0-4+1.5 LU 8CHC +102
Sep 14th@WSHL 3-4-1.5 LU 8.5WSH -120
Sep 13th@WSHW 5-1-1.5 WU 9PIT -115
Sep 12th@WSHL 5-6-1.5 LO 8.5WSH -110

Pirates vs. Cubs Injury Updates

Pirates Injuries

  • Johan Oviedo
    SP

    Oviedo is questionable with elbow

    Questionable

  • Endy Rodriguez
    1B

    Rodriguez is out with elbow

    Out

  • Jared Jones
    SP

    Jones is out with elbow

    Out

Cubs Injuries

  • Michael Soroka
    SP

    Soroka is out with shoulder

    Out

  • Justin Steele
    SP

    Steele is out for season with elbow

    Out for Season

Cubs vs. Pirates Box Score
Cubs Player Stats
Projected
PITCHERPCIPKER
Matthew Boyd logoLM.Boyd, P170.200
HITTERSH-ABRHRRBI
Michael Busch logo1M.Busch, 1B0-0100
Nico Hoerner logo2N.Hoerner, 2B1-1100
Ian Happ logo3I.Happ, LF1-1112
Moises Ballesteros logo4M.Ballesteros, DH1-1111
Seiya Suzuki logo5S.Suzuki, RF0-0000
Pete Crow-Armstrong logo6P.Crow-Armstrong, CF0-1000
Dansby Swanson logo7D.Swanson, SS1-1000
Reese McGuire logo8R.McGuire, C0-1000
Matt Shaw logo9M.Shaw, 3B-
Pirates Player Stats
Projected
PITCHERPCIPKER
Johan Oviedo logoRJ.Oviedo, P26104
HITTERSH-ABRHRRBI
Jared Triolo logo1J.Triolo, SS0-1000
Nick Gonzales logo2N.Gonzales, 2B0-1000
Tommy Pham logo3T.Pham, LF0-0000
Andrew McCutchen logo4A.McCutchen, DH1-1000
Joey Bart logo5J.Bart, C-
Alexander Canario logo6A.Canario, CF-
Nick Yorke logo7N.Yorke, RF-
Rafael Flores logo8R.Flores, 1B-
Cam Devanney logo9C.Devanney, 3B-

Cubs vs. Pirates Odds Comparison

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Cubs at Pirates Team Totals

MatchupOverUnder
Cubs
87-64
N/A
N/A
Pirates
65-87
N/A
N/A