Louisville vs. SMU Odds & Betting Predictions - November 22, 2025
Louisville at SMU
5:00 pm • ESPN2Louisville at SMU Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Louisville 7-3 | +1.5 | +3-110 | o52.5-111 | +124 |
 SMU 7-3 | u50.5 | -3-110 | u52.5-110 | -149 |
Gerald J. Ford StadiumDallas
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Louisville vs. SMU Expert Picks
Collin Wilson
Last 30d: 92-76-0 (+10.9u)
SMU -3-110
1.1u
Project SMU -3.5; great situational spot, Louisville on back to back losses and off Clemson w Kentucky rivalry on deck. SMU off a bye week
Louisville vs. SMU Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Louisville vs. SMU Public Betting Percentages
Betting Trends
- SMU are 5-0 in their last 5 games.
- SMU are 2-3 in their last 5 games against the spread
- SMU are 2-3 in their road games against the spread
- The totals have gone OVER in 0 of SMU' last 5 games
- The totals have gone OVER in 1 of SMU' 5 last games at home
Matchup History
Against the Spread (ATS) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 4-6 | 2-3 | 2-3 | 2-4 | 2-1 |
| 3-7 | 0-7 | 3-0 | 2-7 | 1-0 |
Over/Under History
| overall | home o/u | away o/u | favorite o/u | underdog o/u | |
|---|---|---|---|---|---|
| 3-7 | 1-4 | 2-3 | 2-4 | 1-2 |
| 5-5 | 4-3 | 1-2 | 5-4 | 0-1 |
Straight-Up (ML) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 7-3 | N/A | N/A | 4-2 | 2-1 |
| 7-3 | N/A | N/A | 6-3 | 1-0 |
Last 5 Matchups
Team Stats
2433
YDS
2845
226/353
Comps/Atts
230/354
6.89
YPA
8.04
13/8
TDs/INTs
21/9
19/144
Sacks/Yards
16/155
/
Penalties/Yards
/
Louisville vs. SMU Odds Comparison
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Louisville at SMU Team Totals
MatchupOverUnder | ||
|---|---|---|
Louisville 7-3 | N/A | N/A |
SMU 7-3 | N/A | N/A |