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Duke vs. Syracuse Odds & Betting Predictions - September 27, 2025

Duke at Syracuse

4:00 pm • ACC Network

Duke Blue Devils

5-3
38
38 - 3

Syracuse Orange

3-6
3

Duke at Syracuse Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Duke
5-3
-3.5
-4.5-110
o55.5-110
-185
Syracuse
3-6
u55.5
+4.5-110
u55.5-110
+155
location pinSaturday 4:00 p.m.
September 27, 2025
JMA Wireless DomeSyracuse
Duke vs. Syracuse Expert Picks
The Propfessor
The Propfessor
Last 30d: 45-53-1 (+2.6u)
R.Collins o242.5 Pass Yds-115
1u
Jeremiah Rose
Jeremiah Rose
Last 30d: 25-32-0 (-2.0u)
SYR +4.5-114
0.4u
Collin Wilson
Collin Wilson
Last 30d: 84-63-0 (+19.4u)
Over 59-115
1.15u
Sir Lockselot
Sir Lockselot
Last 30d: 28-59-0 (-19.6u)
SYR +160
3u
📚Player Profit 🔑 Syracuse ML +160 (Player Profit) 3u Cuse is rolling rn, at home in a good home environment. 2 basketball schools playing some good football rn, i love Cuse here. Sharp money on them too, we love it. Code: sirlocks for 10% off every deposit at https://www.playerprofit.com/
Ryan Sura
Ryan Sura
Last 30d: 93-92-1 (+0.6u)
DUKE -4-110
1u
Picks Office
Picks Office
Last 30d: 162-146-4 (+7.2u)
Over 60.5+100
1u
Brian Bitler
Brian Bitler
Last 30d: 78-82-2 (-20.0u)
DUKE -4-110
2.73u
Dan Gaspar
Dan Gaspar
Last 30d: 51-47-2 (-2.2u)
D.Mensah o277.5 Pass Yds-115
1.15u
Mike Calabrese
Mike Calabrese
Last 30d: 35-46-0 (-10.6u)
Under 60.5-110
1u
Manny Diaz is going to force Rickie Collins to win from the pocket. A lot of empty possessions are on deck for the 🍊
Babs .
Babs .
Last 30d: 103-121-3 (-16.4u)
Over 58.5-113
1u
Duck
Duck
Last 30d: 83-77-4 (-1.7u)
DUKE -3.5-110
1u

Duke vs. Syracuse Previews & Analysis

  • Our NCAAF Best Bets for Saturday's Noon Games article feature image

    Our NCAAF Best Bets for Saturday's Noon Games

    Action Network Staff•
    Sep 27, 2025 UTC
  • Your Week 5 NCAAF Betting Cheat Sheet article feature image

    Your Week 5 NCAAF Betting Cheat Sheet

    Pete Ruden•
    Sep 27, 2025 UTC
  • Our Top NCAAF Props for Week 5 article feature image

    Our Top NCAAF Props for Week 5

    Doug Ziefel•
    Sep 27, 2025 UTC
  • Our Over/Under Pick for Duke vs. Syracuse article feature image

    Our Over/Under Pick for Duke vs. Syracuse

    Doug Ziefel•
    Sep 27, 2025 UTC
See more NCAAF Coverage Right Arrow

Prop Odds Comparison

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No props found

Line Movement Tracker

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Duke vs. Syracuse Public Betting Percentages

Away Logo

Duke

Public

Home Logo

Syracuse

55%

Bets%

45%

Money%

NCAAF Public Betting Right Arrow

Betting Trends

  • Syracuse are 2-3 in their last 5 games.
  • Syracuse are 3-2 in their last 5 games against the spread
  • Syracuse are 2-1 in their road games against the spread
  • The totals have gone OVER in 2 of Syracuse' last 5 games
  • The totals have gone OVER in 1 of Syracuse' 5 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Syracuse		3-5-11-3-12-10-1-12-4
Duke		4-41-33-13-21-2

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Syracuse		4-51-42-10-23-3
Duke		6-23-13-13-23-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Syracuse		3-6N/AN/A1-11-5
Duke		5-3N/AN/A4-11-2

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 20th@CLEMW 34-21+17.5 WO 53.5SYR +600
Sep 12thCGTW 66-24-36.5 WO 64.5-
Sep 6thUCONNW 27-20-7 LU 57.5SYR -275
Aug 30th@TENNL 26-45+13.5 LO 51.5TENN +425
Dec 28th@WSUW 52-35-19 LO 58.5SYR -1050
Team Stats

Total

503
Total Yards
314
65
Total Plays
64
7.7384615384615385
Yards Per Play
4.90625

Passing

268
YDS
229
22/28
Comps/Atts
24/37
9.571428571428571
YPA
6.1891891891891895
2/0
TDs/INTs
0/1
2/23
Sacks/Yards
1/7

Rushing

235
Rush Yards
85
37
Attempts
27
6.351351351351352
YPC
3.1481481481481484
3
TDs
0

Turnovers

0
Fumbles Lost
2
0
Interceptions
1

Efficiency

4/4 100%
Redzone
1/2 50%
6/13 0%
3rd Down
5/14 0%
2/2 0%
4th Down
1/3 0%

First Downs

23
Total
19
11
Pass
12
11
Rush
4
1
Penalty
3

Misc

9/105
Penalties/Yards
4/55

Duke vs. Syracuse Odds Comparison

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Duke at Syracuse Team Totals

MatchupOverUnder
Duke
5-3
o31.5-112
u31.5-114
Syracuse
3-6
o27.5-115
u27.5-115