Duke vs. Syracuse Odds & Betting Predictions - September 27, 2025
Duke at Syracuse
4:00 pm • ACC NetworkDuke at Syracuse Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Duke 2-2 | -3.5 | -5.5-110 | o55.5-110 | -162 |
 Syracuse 3-1 | u55.5 | +5.5-110 | u55.5-110 | +134 |
JMA Wireless DomeSyracuse
Duke vs. Syracuse Expert Picks
Dan Gaspar
Last 30d: 27-21-5 (+4.6u)
D.Mensah o277.5 Pass Yds-115
1.15u
Mike Calabrese
Last 30d: 18-30-0 (-11.4u)
Under 60.5-110
1.1u
Manny Diaz is going to force Rickie Collins to win from the pocket. A lot of empty possessions are on deck for the 🍊
Babs .
Last 30d: 78-63-1 (+12.8u)
Over 58.5-113
1u
Duck
Last 30d: 88-62-0 (+16.2u)
DUKE -3.5-110
1.1u
Duke vs. Syracuse Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Duke vs. Syracuse Public Betting Percentages
Betting Trends
- Syracuse are 3-1 in their last 5 games.
- Syracuse are 2-1 in their last 5 games against the spread
- Syracuse are 1-0 in their road games against the spread
- The totals have gone OVER in 3 of Syracuse' last 4 games
- The totals have gone OVER in 1 of Syracuse' 2 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Team Stats
1327
YDS
1415
101/152
Comps/Atts
105/170
8.73
YPA
8.32
11/2
TDs/INTs
12/3
7/30
Sacks/Yards
11/67
Duke vs. Syracuse Odds Comparison
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Duke at Syracuse Team Totals
MatchupOverUnder | ||
|---|---|---|
Duke 2-2 | N/A | N/A |
Syracuse 3-1 | N/A | N/A |