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49ers vs. Cardinals Odds & Betting Predictions - November 16, 2025

49ers at Cardinals

9:05 pm • FOX

San Francisco 49ers

6-3
@

Arizona Cardinals

2-5

49ers at Cardinals Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
6-3
N/A
N/A
N/A
Cardinals
2-5
N/A
N/A
N/A
location pinSunday 9:05 p.m.
November 16, 2025
State Farm StadiumGlendale

49ers vs. Cardinals Props

Prop Projections

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49ers vs. Cardinals Public Betting Percentages

Away Logo

49ers

Public

Home Logo

Cardinals

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Cardinals are 1-4 in their last 5 games.
  • Cardinals are 3-2 in their last 5 games against the spread
  • Cardinals are 3-0 in their road games against the spread
  • The totals have gone OVER in 2 of Cardinals' last 5 games
  • The totals have gone OVER in 3 of Cardinals' 4 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cardinals		4-31-33-01-23-1
49ers		5-41-24-23-22-2

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cardinals		4-33-11-22-12-2
49ers		5-41-24-23-22-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cardinals		2-5N/AN/A2-10-4
49ers		6-3N/AN/A4-12-2

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Oct 19thGBL 23-27+7 WO 44.5GB +270
Oct 12th@INDL 27-31+8.5 WO 46.5IND +350
Oct 5thTENL 21-22-7.5 LO 41.5TEN -420
Sep 26thSEAL 20-23+1.5 LU 43.5SEA +102
Sep 21st@SFL 15-16+1.5 WU 44.5SF +105

49ers vs. Cardinals Injury Updates

49ers Injuries

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Brock Purdy
    QB

    Purdy is out with toe

    Out

  • Ricky Pearsall
    WR

    Pearsall is out with knee

    Out

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

  • Jordan James
    RB

    James is doubtful with finger

    Doubtful

Cardinals Injuries

  • James Conner
    RB

    Conner is out with foot

    Out

  • Kyler Murray
    QB

    Murray is out with foot

    Out

  • Owen Pappoe
    LB

    Pappoe is questionable with quad

    Questionable

  • Trey Benson
    RB

    Benson is out with knee

    Out

  • Tip Reiman
    TE

    Reiman is out with ankle

    Out

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Kyler Murray logo
    Kyler Murray
    962
    pyds
  • passing touchdowns
    Kyler Murray logo
    Kyler Murray
    6
    ptd
  • rushing yards
    Kyler Murray logo
    Kyler Murray
    173
    ryds
  • rushing touchdowns
    Bam Knight logo
    Bam Knight
    2
    rtd
Depth Charts
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Starter2ND3RD4TH
QBKyler MurrayJacoby Brissett
RBJames ConnerTrey BensonEmari DemercadoMichael CarterZonovan Knight
WRGreg DortchZay JonesAndre Baccellia
TETrey McBrideTip ReimanElijah HigginsTravis VokolekJosiah Deguara
LTParis JohnsonKelvin Beachum
LGEvan BrownNick Leverett
CHjalte FroholdtJon Gaines
RGIsaiah AdamsWill HernandezHayden Conner
RTJonah WilliamsChristian JonesJosh FryarJeremiah Byers
LDECalais CampbellWalter NolenL.J. CollierAnthony Goodlow
RDEDarius RobinsonJustin JonesBilal Nichols
WLBAkeem Davis-GaitherOwen Pappoe
MLBMack WilsonCody SimonJ.J. Russell
LCBWill JohnsonElijah Jones
SSJalen ThompsonDadrion Taylor-Demerson
FSBudda BakerJoey BlountKitan Crawford
RCBMax MeltonDenzel Burke
PBlake Gillikin
HBlake Gillikin
PRGreg DortchXavier Weaver
KRGreg DortchAndre Baccellia
LSAaron Brewer
ROLBJosh SweatBJ OjulariXavier Thomas
NTDalvin TomlinsonDante StillsPJ Mustipher
RWRMichael WilsonXavier Weaver
LOLBBaron BrowningZaven CollinsJordan BurchElliott Brown
LWRMarvin HarrisonSimi FehokoTejhaun Palmer
NBGarrett WilliamsKei'Trel ClarkDarren Hall
KChad Ryland
Team Stats

Passing

2295
YDS
1399
216/323
Comps/Atts
162/242
7.486
YPA
6.45
14/9
TDs/INTs
10/4
18/123
Sacks/Yards
24/162

Rushing

874
Rush Yards
773
249
Attempts
175
3.51
YPC
4.417
5
TDs
5

Turnovers

Fumbles Lost
9
Interceptions
4

Efficiency

17/30 56.67%
Redzone
15/27 55.56%
57/121 0%
3rd Down
43/96 0%
7/12 0%
4th Down
4/7 0%

First Downs

192
Total
133
123
Pass
80
55
Rush
38
14
Penalty
15

Misc

/
Penalties/Yards
/
Possession

49ers vs. Cardinals Odds Comparison

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49ers at Cardinals Team Totals

MatchupOverUnder
49ers
6-3
N/A
N/A
Cardinals
2-5
N/A
N/A