49ers vs. Cardinals Odds & Betting Predictions - November 16, 2025
49ers at Cardinals
9:05 pm • FOX49ers at Cardinals Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
49ers 6-3 | N/A | N/A | N/A | |
Cardinals 2-5 | N/A | N/A | N/A | |

State Farm StadiumGlendale
49ers vs. Cardinals Props
Prop Projections
There are no prop projections found for the selected slate. Please check back later.
Prop Odds Comparison
Line Movement Tracker
49ers vs. Cardinals Public Betting Percentages
Betting Trends
- Cardinals are 1-4 in their last 5 games.
- Cardinals are 3-2 in their last 5 games against the spread
- Cardinals are 3-0 in their road games against the spread
- The totals have gone OVER in 2 of Cardinals' last 5 games
- The totals have gone OVER in 3 of Cardinals' 4 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
49ers vs. Cardinals Injury Updates

49ers Injuries
- Brandon AiyukWR
Aiyuk is out with knee
Out
- Brock PurdyQB
Purdy is out with toe
Out
- Ricky PearsallWR
Pearsall is out with knee
Out
- Jacob CowingWR
Cowing is out with hamstring
Out
- Jordan JamesRB
James is doubtful with finger
Doubtful

Cardinals Injuries
- James ConnerRB
Conner is out with foot
Out
- Kyler MurrayQB
Murray is out with foot
Out
- Owen PappoeLB
Pappoe is questionable with quad
Questionable
- Trey BensonRB
Benson is out with knee
Out
- Tip ReimanTE
Reiman is out with ankle
Out
Player Stats
- passing yards
Kyler Murray962pyds - passing touchdowns
Kyler Murray6ptd - rushing yards
Kyler Murray173ryds - rushing touchdowns
Bam Knight2rtd
Depth Charts
| Starter | 2ND | 3RD | 4TH | ||
|---|---|---|---|---|---|
| QB | Kyler Murray | Jacoby Brissett | |||
| RB | James Conner | Trey Benson | Emari Demercado | Michael Carter | Zonovan Knight |
| WR | Greg Dortch | Zay Jones | Andre Baccellia | ||
| TE | Trey McBride | Tip Reiman | Elijah Higgins | Travis Vokolek | Josiah Deguara |
| LT | Paris Johnson | Kelvin Beachum | |||
| LG | Evan Brown | Nick Leverett | |||
| C | Hjalte Froholdt | Jon Gaines | |||
| RG | Isaiah Adams | Will Hernandez | Hayden Conner | ||
| RT | Jonah Williams | Christian Jones | Josh Fryar | Jeremiah Byers | |
| LDE | Calais Campbell | Walter Nolen | L.J. Collier | Anthony Goodlow | |
| RDE | Darius Robinson | Justin Jones | Bilal Nichols | ||
| WLB | Akeem Davis-Gaither | Owen Pappoe | |||
| MLB | Mack Wilson | Cody Simon | J.J. Russell | ||
| LCB | Will Johnson | Elijah Jones | |||
| SS | Jalen Thompson | Dadrion Taylor-Demerson | |||
| FS | Budda Baker | Joey Blount | Kitan Crawford | ||
| RCB | Max Melton | Denzel Burke | |||
| P | Blake Gillikin | ||||
| H | Blake Gillikin | ||||
| PR | Greg Dortch | Xavier Weaver | |||
| KR | Greg Dortch | Andre Baccellia | |||
| LS | Aaron Brewer | ||||
| ROLB | Josh Sweat | BJ Ojulari | Xavier Thomas | ||
| NT | Dalvin Tomlinson | Dante Stills | PJ Mustipher | ||
| RWR | Michael Wilson | Xavier Weaver | |||
| LOLB | Baron Browning | Zaven Collins | Jordan Burch | Elliott Brown | |
| LWR | Marvin Harrison | Simi Fehoko | Tejhaun Palmer | ||
| NB | Garrett Williams | Kei'Trel Clark | Darren Hall | ||
| K | Chad Ryland |
Team Stats
2295
YDS
1399
216/323
Comps/Atts
162/242
7.486
YPA
6.45
14/9
TDs/INTs
10/4
18/123
Sacks/Yards
24/162
17/30 56.67%
Redzone
15/27 55.56%
57/121 0%
3rd Down
43/96 0%
7/12 0%
4th Down
4/7 0%
49ers vs. Cardinals Odds Comparison
Could not load odds
49ers at Cardinals Team Totals
MatchupOverUnder | ||
|---|---|---|
49ers 6-3 | N/A | N/A |
Cardinals 2-5 | N/A | N/A |
