49ers vs. Rams Odds & Betting Predictions - September 17, 2023
49ers at Rams
8:05 pm • FOX49ers at Rams Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
---|---|---|---|---|
![]() 49ers 0-1 | -7.5-106 | o45-110 | -340 | |
![]() Rams 1-0 | +7.5-115 | u45-110 | +265 |

SoFi StadiumInglewood
49ers vs. Rams Expert Picks

Mjaybrod
Last 30d: 1-1-0 (-0.0u)
LA +8.5-115
0.87u
Got a good number live

Sean Koerner
Last 30d: 10-12-0 (-0.9u)
K.Williams u3.5 Recs-120
1.2u

Kyle "Vince" Akins
Last 30d: 0-0-0 (+0.0u)
Under 45.5-110
1.1u

Markus Markets
Last 30d: 11-9-1 (+0.8u)
C.McCaffrey o99.5 Rush + Rec Yds-114
0.88u

Sean Zerillo
Last 30d: 134-163-6 (-3.3u)
Over 45-110
0.5u

Stephen Nover
Last 30d: 0-1-0 (-1.0u)
SF -7-110
1u
49ers have owned the Rams during the regular season. Kupp' absence will be felt here.
Scott Rickenbach
Last 30d: 76-61-4 (+3.5u)
LA +7.5-115
0.87u

Steak Friend
Last 30d: 0-0-0 (+0.0u)
LA +7.5-112
1u
Daniel Dobish
Last 30d: 0-0-0 (+0.0u)
Under 45.5-110
1u

Milly Props
Last 30d: 0-0-0 (+0.0u)
D.Samuel o46.5 Rec Yds-114
0.88u

Simon Hunter
Last 30d: 1-0-0 (+1.0u)
LA +7.5-112
0.89u

Brandon Anderson
Last 30d: 0-2-0 (-0.5u)
M.Stafford o224.5 Pass Yds-115
0.87u
Stafford can beat these corners. He’s over this number in 23/27 Rams games (85%) and 3 of the under were his final games injured last season before shutting it down.
https://www.actionnetwork.com/nfl/nfl-week-2-2023

Sean Koerner
Last 30d: 10-12-0 (-0.9u)
B.Aiyuk u4.5 Recs-113
1u

Prop Bet Guy
Last 30d: 0-0-0 (+0.0u)
T.Higbee u16.5 Longest Reception-114
1u
Tight ends against the 49ers is like a death trap - sixth fewest YPC and fourth fewest yards per target last season. Last week was more of the same, with Steelers tight ends registering 22 yards on 8 targets (long of 11). Part of the reason is tight ends will need to help in pass protection against the 49ers d line, then have to deal with the likes of Werner, Greenlaw and Hafuanga in coverage. Higbee is not fast enough to be a concern on the deep balls or with YAC. Last season, Higbee long catch was 12 yards in two games vs the 49ers (despite 20 targets and 12 catches). Atwell and Jefferson figure to command the deep shots with PUCA NAKUA dominating intermediate targets (or Skrowronek if Puka doesn’t play).
Would play down to u15.5.

Bruce Marshall
Last 30d: 0-0-0 (+0.0u)
SF -7.5-110
1u

Stuck 🚨
Last 30d: 1-1-0 (+0.0u)
Over 44.5-110
0.36u

Jim Sannes
Last 30d: 20-46-0 (-10.7u)
LA +8-110
0.91u
Available at FanDuel. My model was on the Rams' spread in Week 1, so I'm not surprised we're here again after how they performed. The key thing is that Matthew Stafford looked healthy, something that boosts the Rams' entire team from where preseason models had them when playing out the full season. The defense also stepped up, though it was aided by injuries to Seattle's offensive line. It's possible that the 49ers are just a juggernaut that my model can't catch up to. I'm fully open to that possibility. But for now, I do think taking 8 points on the home team is the right move.
PRO Insights

49ers
SF Insights
- Featured Insight
The Rams have scored 18.7 points per game since the 2022 season -- eighth-worst in NFL. The 49ers have allowed 15.8 PPG since the 2022 season -- best in NFL.
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Rams
LA Insights
- Featured Insight
The Rams have run successful plays on 39.0% of rush attempts since the 2022 season -- tied for fourth-worst in NFL. 49ers have allowed successful plays on 38.0% of rush attempts since the 2022 season -- second-best in NFL.
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49ers vs. Rams Previews & Analysis
49ers vs. Rams Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
49ers vs. Rams Public Betting Percentages
Betting Trends
- Rams are 4-1 in their last 5 games.
- Rams are 4-1 in their last 5 games against the spread
- Rams are 5-3 in their road games against the spread
- The totals have gone OVER in 2 of Rams' last 5 games
- The totals have gone OVER in 5 of Rams' 9 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Rams vs. 49ers Injury Updates

Rams Injuries

49ers Injuries
- Trevis GipsonLB
Gipson is out with ankle
Out
Team Stats
49ers vs. Rams Odds Comparison
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49ers at Rams Team Totals
MatchupOverUnder | ||
---|---|---|
![]() 49ers 0-1 | o26.5-119 | u26.5-104 |
![]() Rams 1-0 | o18.5-110 | u18.5-107 |