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Colts vs. Titans Odds & Betting Predictions - September 21, 2025

Colts at Titans

5:00 pm • CBS
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Indianapolis Colts

2-0
@

Tennessee Titans

0-2

Colts at Titans Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Colts
2-0
+1.5
-3-120
o43.5-110
-165
Titans
0-2
u45.5
+3+100
u43.5-110
+140
location pinSunday 5:00 p.m.
September 21, 2025
Nissan StadiumNashville
thermometer image78°Fahrenheit
rain image0%Rain
wind image9Wind
Colts vs. Titans Expert Picks
Boomer Betz
Boomer Betz
Last 30d: 136-147-0 (-4.8u)
TEN +3.5-110
1u
Bet105 bit.ly/boomerh1
FTN Fantasy
FTN Fantasy
Last 30d: 64-95-0 (-36.9u)
TEN +3.5-115
1u
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 132-154-2 (-30.7u)
Under 43.5-110
1u

Colts vs. Titans Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Colts vs. Titans Public Betting Percentages

Away Logo

Colts

Public

Home Logo

Titans

57%

Bets%

43%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Titans are 0-2 in their last 5 games.
  • Titans are 1-1 in their last 5 games against the spread
  • Titans are 1-0 in their road games against the spread
  • The totals have gone OVER in 1 of Titans' last 2 games
  • The totals have gone OVER in 1 of Titans' 1 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Titans		1-10-11-0N/A1-1
Colts		2-02-0N/A1-01-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Titans		1-11-00-1N/A1-1
Colts		1-11-1N/A0-11-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Titans		0-2N/AN/AN/A0-2
Colts		2-0N/AN/A1-01-0

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 14thLAL 19-33---
Sep 7th@DENL 12-20+8.5 WU 42.5DEN +370
Aug 23rdMINW 23-13-3.5 WU 37TEN -170
Aug 15th@ATLW 23-20-2.5 WO 36.5TEN -145
Aug 9th@TBL 7-29-3.5 LO 34.5TB -196

Titans vs. Colts Injury Updates

Titans Injuries

  • Tyjae Spears
    RB

    Spears is out with ankle

    Out

  • Kevin Winston
    S

    Winston is doubtful with hamstring

    Doubtful

  • Kalel Mullings
    RB

    Mullings is out with ankle

    Out

Colts Injuries

  • Tyler Goodson
    RB

    Goodson is questionable with elbow

    Questionable

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Cam Ward logo
    Cam Ward
    112
    pyds
  • passing touchdowns
    player logo
    -
    -
    ptd
  • rushing yards
    Tony Pollard logo
    Tony Pollard
    60
    ryds
  • rushing touchdowns
    player logo
    -
    -
    rtd
Depth Charts
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Starter2ND3RD4TH
QBCam WardBrandon AllenTrevor Siemian
RBTony PollardTyjae SpearsKalel MullingsJulius ChestnutJordan Mims
WRTyler LockettChimere DikeXavier RestrepoMason Kinsey
TEChig OkonkwoGunnar HelmDavid Martin-RobinsonThomas OdukoyaDrake Dabney
LTDan MooreJohn OjukwuOlisaemeka Udoh
LGPeter SkoronskiJackson SlaterAndrew Rupcich
CLloyd CushenberryCorey Levin
RGKevin ZeitlerBlake Hance
RTJC Latham
RDESebastian Joseph-DayCarlos Watkins
LCBL'Jarius SneedDarrell Baker
SSAmani HookerKevin Winston
FSXavier WoodsQuandre DiggsMike Brown
RCBJarvis BrownleeMarcus Harris
PJohnny Hekker
HJohnny Hekker
PRJames ProcheChimere DikeXavier Restrepo
KRChimere DikeTyjae Spears
LSMorgan Cox
RWRCalvin RidleyBryce Oliver
KJoey Slye
RILBCody Barton
NBRoger McCreary
DTJeffery SimmonsJames LynchCam Horsley
LOLBArden KeyOluwafemi OladejoJaylen Harrell
LWRVan JeffersonElic AyomanorJames Proche
LILBJames WilliamsCedric Gray
NTT'Vondre SweatTimmy Horne
ROLBDre'Mont JonesJihad WardAli Gaye
Team Stats

Passing

262
YDS
62
22/29
Comps/Atts
12/28
9.379
YPA
4
1/0
TDs/INTs
0/0
1/10
Sacks/Yards
6/50

Rushing

156
Rush Yards
71
40
Attempts
21
3.9
YPC
3.381
2
TDs
0

Turnovers

Fumbles Lost
0
Interceptions
0

Efficiency

3/6 50%
Redzone
0/2 0%
7/15 0%
3rd Down
2/14 0%
3/3 0%
4th Down
0/1 0%

First Downs

27
Total
7
14
Pass
5
11
Rush
2
2
Penalty
0

Misc

/
Penalties/Yards
/
Possession

Colts vs. Titans Odds Comparison

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Colts at Titans Team Totals

MatchupOverUnder
Colts
2-0
N/A
N/A
Titans
0-2
N/A
N/A