Rams vs. 49ers Odds & Betting Predictions - November 9, 2025

Rams at 49ers

9:25 pm • FOX
42 - 26

Rams at 49ers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Rams
7-2
-3
-5.5-115
o49.5-110
-259
49ers
6-4
u46.5
+5.5-105
u49.5-110
+212
location pinSunday 9:25 p.m.
November 09, 2025
Levi's StadiumSanta Clara
Rams vs. 49ers Expert Picks
Austin Pendergrass
Austin Pendergrass
Last 30d: 45-52-0 (-9.3u)
P.Nacua o7.5 Recs (Live)-126
1u
Nick Giffen
Nick Giffen
Last 30d: 56-64-0 (+13.1u)
K.Williams 2+ TDs Yes+500
1u
K.Williams Anytime TD Scorer Yes+100
1u
Gilles Gallant
Gilles Gallant
Last 30d: 31-89-1 (-9.8u)
K.Williams Anytime TD Scorer Yes+100
0.5u
Dale Tanhardt
Dale Tanhardt
Last 30d: 2-6-0 (-0.3u)
G.Kittle Anytime TD Scorer Yes+150
1.8u
D.Allen Anytime TD Scorer Yes+600
3u
Vegas Refund
Vegas Refund
Last 30d: 42-40-1 (-2.1u)
LA -5.5-110
1u
Babs .
Babs .
Last 30d: 107-135-3 (-27.9u)
J.Whittington u1.5 Recs+130
1.3u
YBK Picks.com
Last 30d: 55-40-1 (+28.8u)
LA -5.5-105
1.9u
Moneyline Hacks
Moneyline Hacks
Last 30d: 135-148-2 (+33.3u)
K.Williams Anytime TD Scorer Yes+100
1u
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Sandy Plashkes
Sandy Plashkes
Last 30d: 108-127-3 (-17.1u)
SF +6-110
1.1u
RocketPlays
RocketPlays
Last 30d: 46-102-0 (+4.0u)
B.Corum o25.5 Rush Yds-135
1u
Allan Lem
Allan Lem
Last 30d: 173-117-3 (+18.4u)
C.McCaffrey u13.5 Longest Rush-115
0.5u
Tailing @nick_giffen
Nick Giffen
Nick Giffen
Last 30d: 56-64-0 (+13.1u)
C.McCaffrey u13.5 Longest Rush-115
1u
Christian McCaffrey Longest Rush under 13.5 yards (-115 Bet365, 120 DK/MGM/ESPN) Since McCaffrey returned from injury in 2024, he has just 6 carries out of 194 carries from at least 14 yards from the end zone that have cleared 13.5 yards for a paltry 3.1% compared to the NFL average of 5.5% (removing QB scrambles). This year, CMC has cleared this in just 3 of 9 games, with those coming against the Arizona Cardinals who rank ninth worst in explosive run rate allowed, the Atlanta Falcons in which is took him 24 carries to get a longest run of 15 yards, and the New York Giants who rank third worst in explosive run rate allowed where he cleared his 15.5 longest rush line by the hook on 28 carries (and I gave out over last week in that game). But now he faces a Rams defense that is second-best in preventing explosive runs. Earlier this year when these two teams played, McCaffrey's longest run was just 8 yards on 22 carries. This year, in three games against top-five defenses in preventing explosive runs, McCaffrey has a longest run of just 13 yards on 61 carries. Additionally, the 49ers run zone concept runs with CMC 65% of the time, which is what the Rams defense has been better at stopping (3.86 ypc, 41.8% success rate allowed compared to 4.38 and 51.8% vs. man/gap concept runs). In my most generous projections where I overprojected his carries, fraction of carries from at least 14 yards out, and use generous distributions for his carry length and LA's allowed carry length, I'm still getting he stays under 13.5 almost 63% of the time.
Brandon Anderson
Brandon Anderson
Last 30d: 63-112-1 (+21.5u)
P.Nacua 100+ Receiving Yards Yes+116
0.4u
We took Rams -3 on the Hot Read as our first pick Sunday night. We've got some good value there now that the line is up to -4.5 and rising. There's not much value left on a Rams spread now, but we can still invest in this elite offense against what might be the worst defense in the league. San Francisco has been demolished by injuries. The 49ers rank 31st in EPA per play against the middle of the field too, so Puka Nacua should eat, and Matthew Stafford had his biggest game of the season in the first meeting. Usually with Nacua, I just want receptions, but books are steering us away by pricing 8+ receptions at -130 juiced. But when Nacua does catch at least eight passes, as he's done 15 times in his career, he also racks up yardage — at least 85 yards in all but one game, with 100+ yards in 11 of 15 (73%). The 49ers allow the seventh-most yards to opposing WRs. Nacua had 10 catches for 85 yards in the first meeting this year, and the similarly-styled Jaxon Smith-Njigba had 9/124. The 49ers also rank bottom 10 in EPA per play against deep passes while the Rams rank top four passing deep and go there often, leaving the possibility of a big chunk play. Play Nacua 100+ receiving yards at +116 (DraftKings). He averages 126 YPG in his 15 games with 8+ catches, and he topped 150 yards in 40% of them, so play the yardage escalator at 120 yards for +223 and 150+ at +600 (both at DraftKings).
P.Nacua o119.5 Rec Yds+223
0.25u
We took Rams -3 on the Hot Read as our first pick Sunday night. We've got some good value there now that the line is up to -4.5 and rising. There's not much value left on a Rams spread now, but we can still invest in this elite offense against what might be the worst defense in the league. San Francisco has been demolished by injuries. The 49ers rank 31st in EPA per play against the middle of the field too, so Puka Nacua should eat, and Matthew Stafford had his biggest game of the season in the first meeting. Usually with Nacua, I just want receptions, but books are steering us away by pricing 8+ receptions at -130 juiced. But when Nacua does catch at least eight passes, as he's done 15 times in his career, he also racks up yardage — at least 85 yards in all but one game, with 100+ yards in 11 of 15 (73%). The 49ers allow the seventh-most yards to opposing WRs. Nacua had 10 catches for 85 yards in the first meeting this year, and the similarly-styled Jaxon Smith-Njigba had 9/124. The 49ers also rank bottom 10 in EPA per play against deep passes while the Rams rank top four passing deep and go there often, leaving the possibility of a big chunk play. Play Nacua 100+ receiving yards at +116 (DraftKings). He averages 126 YPG in his 15 games with 8+ catches, and he topped 150 yards in 40% of them, so play the yardage escalator at 120 yards for +223 and 150+ at +600 (both at DraftKings).
P.Nacua 150+ Receiving Yards Yes+600
0.1u
We took Rams -3 on the Hot Read as our first pick Sunday night. We've got some good value there now that the line is up to -4.5 and rising. There's not much value left on a Rams spread now, but we can still invest in this elite offense against what might be the worst defense in the league. San Francisco has been demolished by injuries. The 49ers rank 31st in EPA per play against the middle of the field too, so Puka Nacua should eat, and Matthew Stafford had his biggest game of the season in the first meeting. Usually with Nacua, I just want receptions, but books are steering us away by pricing 8+ receptions at -130 juiced. But when Nacua does catch at least eight passes, as he's done 15 times in his career, he also racks up yardage — at least 85 yards in all but one game, with 100+ yards in 11 of 15 (73%). The 49ers allow the seventh-most yards to opposing WRs. Nacua had 10 catches for 85 yards in the first meeting this year, and the similarly-styled Jaxon Smith-Njigba had 9/124. The 49ers also rank bottom 10 in EPA per play against deep passes while the Rams rank top four passing deep and go there often, leaving the possibility of a big chunk play. Play Nacua 100+ receiving yards at +116 (DraftKings). He averages 126 YPG in his 15 games with 8+ catches, and he topped 150 yards in 40% of them, so play the yardage escalator at 120 yards for +223 and 150+ at +600 (both at DraftKings).
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 84-135-0 (+8.7u)
P.Nacua o119.5 Rec Yds+223
0.45u
P.Nacua 100+ Receiving Yards Yes+116
0.86u
P.Nacua 150+ Receiving Yards Yes+600
0.17u
TAN Pod Touchdown Show
TAN Pod Touchdown Show
Last 30d: 32-111-2 (-8.5u)
J.Jennings Anytime TD Scorer Yes+250
1.25u
K.Williams Anytime TD Scorer Yes+100
0.5u
Grant Neiffer
Grant Neiffer
Last 30d: 49-88-2 (+12.4u)
K.Williams Anytime TD Scorer Yes+110
0.55u
Boomer Betz
Boomer Betz
Last 30d: 224-201-10 (+24.1u)
G.Kittle o45.5 Rec Yds-115
1u
K.Williams o2.5 Recs+140
1u
@Locko_Rocco
Moneyline Hacks
Moneyline Hacks
Last 30d: 135-148-2 (+33.3u)
Under 49.5-110
1u
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Kenny Ducey
Kenny Ducey
Last 30d: 24-17-0 (+6.5u)
LA -4.5-110
1u
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 84-135-0 (+8.7u)
Over 49.5-110
0.91u
@Stuckey2 Favorite Total https://myaction.app/25SlQ7HP4Xb
SF +4.5-110
1u
Sunday Six Pack
Sunday Six Pack
Last 30d: 15-15-0 (-1.5u)
SF +4.5-110
1.1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 111-112-10 (+10.7u)
LA -4-115
1.5u
LA -4-110
1u
Chris Raybon
Chris Raybon
Last 30d: 16-21-1 (-5.4u)
SF +4.5+100
1u
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 84-135-0 (+8.7u)
LA -3-105
0.95u
@wheatonbrando Week 10 Hot Read https://myaction.app/pW5ZLhuMZXb
Brandon Anderson
Brandon Anderson
Last 30d: 63-112-1 (+21.5u)
LA -3-110
1.36u
🔥 Week 10 Hot Read 🔥
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 235-218-10 (+1.6u)
LA -3+108
0.97u
4% ev play to +100

Rams vs. 49ers Previews & Analysis

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  • Koerner & Raybon's Week 10 Spreads & Totals article feature image

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Rams vs. 49ers Props

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Prop Odds Comparison

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Line Movement Tracker

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Rams vs. 49ers Public Betting Percentages

Away Logo

Rams

Public

48%

Bets%

52%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
49ers
5-51-34-23-22-3
Rams
7-23-13-17-10-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
49ers
6-42-24-23-23-2
Rams
4-51-33-13-51-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
49ers
6-4N/AN/A4-12-3
Rams
7-2N/AN/A7-10-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 2nd@NYGW 34-24-2.5 WO 47.5SF -146
Oct 26th@HOUL 15-26+3 LU 41.5HOU +130
Oct 20thATLW 20-10-0.5 WU 46.5SF -105
Oct 12th@TBL 19-30+3.5 LO 47TB +160
Oct 3rd@LAW 26-23+7.5 WO 43.5SF +340

Rams vs. 49ers Injury Updates

Rams Injuries

  • Tutu Atwell
    WR

    Atwell is out with hamstring

    Out

49ers Injuries

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Brock Purdy
    QB

    Purdy is out with toe

    Out

  • Ricky Pearsall
    WR

    Pearsall is out with knee

    Out

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

  • Jordan James
    RB

    James is doubtful with finger

    Doubtful

Team Stats
401
Total Yards
393
67
Total Plays
60
6
Yards Per Play
6.6

Passing

280
YDS
319
24/36
Comps/Atts
33/39
7.432
YPA
8.179
4/0
TDs/INTs
3/1
1/5
Sacks/Yards
0/0

Rushing

126
Rush Yards
74
30
Attempts
21
4.2
YPC
3.524
2
TDs
1

Turnovers

0
Fumbles Lost
1
0
Interceptions
1

Efficiency

5/6 83.33%
Redzone
4/5 80%
5/9 0%
3rd Down
3/8 0%
1/1 0%
4th Down
1/3 0%

First Downs

31
Total
24
20
Pass
16
9
Rush
8
2
Penalty
0
0/0
Penalties/Yards
7/45
32:32
Possession
27:28

Rams vs. 49ers Odds Comparison

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Rams at 49ers Team Totals

MatchupOverUnder
Rams
7-2
o27.5-115
u27.5-105
49ers
6-4
o21.5-110
u21.5-110