Rams vs. 49ers Odds & Betting Predictions - November 9, 2025
Rams at 49ers
9:25 pm • FOXRams at 49ers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Rams 7-2 | -3 | -5.5-115 | o49.5-110 | -259 |
49ers 6-4 | u46.5 | +5.5-105 | u49.5-110 | +212 |

Levi's StadiumSanta Clara
Rams vs. 49ers Expert Picks
Austin Pendergrass
Last 30d: 45-52-0 (-9.3u)
P.Nacua o7.5 Recs (Live)-126
1u
Nick Giffen
Last 30d: 56-64-0 (+13.1u)
K.Williams 2+ TDs Yes+500
1u
K.Williams Anytime TD Scorer Yes+100
1u
Gilles Gallant
Last 30d: 31-89-1 (-9.8u)
K.Williams Anytime TD Scorer Yes+100
0.5u
Dale Tanhardt
Last 30d: 2-6-0 (-0.3u)
G.Kittle Anytime TD Scorer Yes+150
1.8u
D.Allen Anytime TD Scorer Yes+600
3u
Vegas Refund
Last 30d: 42-40-1 (-2.1u)
LA -5.5-110
1u
Babs .
Last 30d: 107-135-3 (-27.9u)
J.Whittington u1.5 Recs+130
1.3u
YBK Picks.com
Last 30d: 55-40-1 (+28.8u)
LA -5.5-105
1.9u
Moneyline Hacks
Last 30d: 135-148-2 (+33.3u)
K.Williams Anytime TD Scorer Yes+100
1u
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Sandy Plashkes
Last 30d: 108-127-3 (-17.1u)
SF +6-110
1.1u
RocketPlays
Last 30d: 46-102-0 (+4.0u)
B.Corum o25.5 Rush Yds-135
1u
Allan Lem
Last 30d: 173-117-3 (+18.4u)
C.McCaffrey u13.5 Longest Rush-115
0.5u
Tailing @nick_giffen
Nick Giffen
Last 30d: 56-64-0 (+13.1u)
C.McCaffrey u13.5 Longest Rush-115
1u
Christian McCaffrey Longest Rush under 13.5 yards (-115 Bet365, 120 DK/MGM/ESPN)
Since McCaffrey returned from injury in 2024, he has just 6 carries out of 194 carries from at least 14 yards from the end zone that have cleared 13.5 yards for a paltry 3.1% compared to the NFL average of 5.5% (removing QB scrambles).
This year, CMC has cleared this in just 3 of 9 games, with those coming against the Arizona Cardinals who rank ninth worst in explosive run rate allowed, the Atlanta Falcons in which is took him 24 carries to get a longest run of 15 yards, and the New York Giants who rank third worst in explosive run rate allowed where he cleared his 15.5 longest rush line by the hook on 28 carries (and I gave out over last week in that game).
But now he faces a Rams defense that is second-best in preventing explosive runs. Earlier this year when these two teams played, McCaffrey's longest run was just 8 yards on 22 carries.
This year, in three games against top-five defenses in preventing explosive runs, McCaffrey has a longest run of just 13 yards on 61 carries.
Additionally, the 49ers run zone concept runs with CMC 65% of the time, which is what the Rams defense has been better at stopping (3.86 ypc, 41.8% success rate allowed compared to 4.38 and 51.8% vs. man/gap concept runs).
In my most generous projections where I overprojected his carries, fraction of carries from at least 14 yards out, and use generous distributions for his carry length and LA's allowed carry length, I'm still getting he stays under 13.5 almost 63% of the time.
Brandon Anderson
Last 30d: 63-112-1 (+21.5u)
P.Nacua 100+ Receiving Yards Yes+116
0.4u
We took Rams -3 on the Hot Read as our first pick Sunday night. We've got some good value there now that the line is up to -4.5 and rising.
There's not much value left on a Rams spread now, but we can still invest in this elite offense against what might be the worst defense in the league. San Francisco has been demolished by injuries. The 49ers rank 31st in EPA per play against the middle of the field too, so Puka Nacua should eat, and Matthew Stafford had his biggest game of the season in the first meeting.
Usually with Nacua, I just want receptions, but books are steering us away by pricing 8+ receptions at -130 juiced. But when Nacua does catch at least eight passes, as he's done 15 times in his career, he also racks up yardage — at least 85 yards in all but one game, with 100+ yards in 11 of 15 (73%).
The 49ers allow the seventh-most yards to opposing WRs. Nacua had 10 catches for 85 yards in the first meeting this year, and the similarly-styled Jaxon Smith-Njigba had 9/124. The 49ers also rank bottom 10 in EPA per play against deep passes while the Rams rank top four passing deep and go there often, leaving the possibility of a big chunk play.
Play Nacua 100+ receiving yards at +116 (DraftKings).
He averages 126 YPG in his 15 games with 8+ catches, and he topped 150 yards in 40% of them, so play the yardage escalator at 120 yards for +223 and 150+ at +600 (both at DraftKings).
P.Nacua o119.5 Rec Yds+223
0.25u
We took Rams -3 on the Hot Read as our first pick Sunday night. We've got some good value there now that the line is up to -4.5 and rising.
There's not much value left on a Rams spread now, but we can still invest in this elite offense against what might be the worst defense in the league. San Francisco has been demolished by injuries. The 49ers rank 31st in EPA per play against the middle of the field too, so Puka Nacua should eat, and Matthew Stafford had his biggest game of the season in the first meeting.
Usually with Nacua, I just want receptions, but books are steering us away by pricing 8+ receptions at -130 juiced. But when Nacua does catch at least eight passes, as he's done 15 times in his career, he also racks up yardage — at least 85 yards in all but one game, with 100+ yards in 11 of 15 (73%).
The 49ers allow the seventh-most yards to opposing WRs. Nacua had 10 catches for 85 yards in the first meeting this year, and the similarly-styled Jaxon Smith-Njigba had 9/124. The 49ers also rank bottom 10 in EPA per play against deep passes while the Rams rank top four passing deep and go there often, leaving the possibility of a big chunk play.
Play Nacua 100+ receiving yards at +116 (DraftKings).
He averages 126 YPG in his 15 games with 8+ catches, and he topped 150 yards in 40% of them, so play the yardage escalator at 120 yards for +223 and 150+ at +600 (both at DraftKings).
P.Nacua 150+ Receiving Yards Yes+600
0.1u
We took Rams -3 on the Hot Read as our first pick Sunday night. We've got some good value there now that the line is up to -4.5 and rising.
There's not much value left on a Rams spread now, but we can still invest in this elite offense against what might be the worst defense in the league. San Francisco has been demolished by injuries. The 49ers rank 31st in EPA per play against the middle of the field too, so Puka Nacua should eat, and Matthew Stafford had his biggest game of the season in the first meeting.
Usually with Nacua, I just want receptions, but books are steering us away by pricing 8+ receptions at -130 juiced. But when Nacua does catch at least eight passes, as he's done 15 times in his career, he also racks up yardage — at least 85 yards in all but one game, with 100+ yards in 11 of 15 (73%).
The 49ers allow the seventh-most yards to opposing WRs. Nacua had 10 catches for 85 yards in the first meeting this year, and the similarly-styled Jaxon Smith-Njigba had 9/124. The 49ers also rank bottom 10 in EPA per play against deep passes while the Rams rank top four passing deep and go there often, leaving the possibility of a big chunk play.
Play Nacua 100+ receiving yards at +116 (DraftKings).
He averages 126 YPG in his 15 games with 8+ catches, and he topped 150 yards in 40% of them, so play the yardage escalator at 120 yards for +223 and 150+ at +600 (both at DraftKings).
Action Pod NFL Picks
Last 30d: 84-135-0 (+8.7u)
P.Nacua o119.5 Rec Yds+223
0.45u
@wheatonbrando https://myaction.app/fo0oUthH6Xb
P.Nacua 100+ Receiving Yards Yes+116
0.86u
@wheatonbrando https://myaction.app/fo0oUthH6Xb
P.Nacua 150+ Receiving Yards Yes+600
0.17u
@wheatonbrando https://myaction.app/fo0oUthH6Xb
TAN Pod Touchdown Show
Last 30d: 32-111-2 (-8.5u)
J.Jennings Anytime TD Scorer Yes+250
1.25u
@ChrisRaybon https://myaction.app/EvaZ2p3F6Xb
K.Williams Anytime TD Scorer Yes+100
0.5u
@ChrisRaybon https://myaction.app/EvaZ2p3F6Xb
Grant Neiffer
Last 30d: 49-88-2 (+12.4u)
K.Williams Anytime TD Scorer Yes+110
0.55u
Boomer Betz
Last 30d: 224-201-10 (+24.1u)
G.Kittle o45.5 Rec Yds-115
1u
K.Williams o2.5 Recs+140
1u
@Locko_Rocco
Moneyline Hacks
Last 30d: 135-148-2 (+33.3u)
Under 49.5-110
1u
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Kenny Ducey
Last 30d: 24-17-0 (+6.5u)
LA -4.5-110
1u
Action Pod NFL Picks
Last 30d: 84-135-0 (+8.7u)
Over 49.5-110
0.91u
@Stuckey2 Favorite Total https://myaction.app/25SlQ7HP4Xb
SF +4.5-110
1u
@ChrisRaybon https://myaction.app/25SlQ7HP4Xb
Sunday Six Pack
Last 30d: 15-15-0 (-1.5u)
SF +4.5-110
1.1u
@ChrisRaybon 2 https://myaction.app/PhqO8ouP4Xb
💰🦡 Jake
Last 30d: 111-112-10 (+10.7u)
LA -4-115
1.5u
LA -4-110
1u

Chris Raybon
Last 30d: 16-21-1 (-5.4u)
SF +4.5+100
1u
Action Pod NFL Picks
Last 30d: 84-135-0 (+8.7u)
LA -3-105
0.95u
@wheatonbrando Week 10 Hot Read https://myaction.app/pW5ZLhuMZXb
Brandon Anderson
Last 30d: 63-112-1 (+21.5u)
LA -3-110
1.36u
🔥 Week 10 Hot Read 🔥
Top Shelf Action 🥃
Last 30d: 235-218-10 (+1.6u)
LA -3+108
0.97u
4% ev play to +100
Rams vs. 49ers Previews & Analysis
Rams vs. 49ers Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
Rams vs. 49ers Public Betting Percentages
Betting Trends
- 49ers are 2-3 in their last 5 games.
- 49ers are 2-3 in their last 5 games against the spread
- 49ers are 4-2 in their road games against the spread
- The totals have gone OVER in 3 of 49ers' last 5 games
- The totals have gone OVER in 2 of 49ers' 4 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Rams vs. 49ers Injury Updates

Rams Injuries
- Tutu AtwellWR
Atwell is out with hamstring
Out

49ers Injuries
- Brandon AiyukWR
Aiyuk is out with knee
Out
- Brock PurdyQB
Purdy is out with toe
Out
- Ricky PearsallWR
Pearsall is out with knee
Out
- Jacob CowingWR
Cowing is out with hamstring
Out
- Jordan JamesRB
James is doubtful with finger
Doubtful
Team Stats
Rams vs. 49ers Odds Comparison
Could not load odds
Rams at 49ers Team Totals
MatchupOverUnder | ||
|---|---|---|
Rams 7-2 | o27.5-115 | u27.5-105 |
49ers 6-4 | o21.5-110 | u21.5-110 |




