Titans vs. 49ers Odds & Betting Predictions - December 14, 2025
Titans at 49ers
9:25 pm • FOXTitans at 49ers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Titans 2-11 | +7.5 | +13-110 | o43.5-111 | +650 |
 49ers 9-4 | u45.5 | -13-110 | u43.5-111 | -1000 |
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Titans vs. 49ers Expert Picks
FTN Fantasy
Last 30d: 114-158-3 (-56.9u)
SF -13.5-111
1u
Titans vs. 49ers Props
Prop Projections
There are no prop projections found for the selected slate. Please check back later.
Prop Odds Comparison
Line Movement Tracker
Titans vs. 49ers Public Betting Percentages
Betting Trends
- 49ers are 2-3 in their last 5 games.
- 49ers are 2-3 in their last 5 games against the spread
- 49ers are 6-2 in their road games against the spread
- The totals have gone OVER in 3 of 49ers' last 5 games
- The totals have gone OVER in 2 of 49ers' 5 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
49ers vs. Titans Injury Updates
49ers Injuries
- Brandon AiyukWR
Aiyuk is out with knee
Out
- Jacob CowingWR
Cowing is out with hamstring
Out
Titans Injuries
- Calvin RidleyWR
Ridley is out with leg
Out
- Bryce OliverWR
Oliver is out with knee
Out
Player Stats
- passing yards
Mac Jones2151pyds - passing touchdownsMac Jones13ptd
- rushing yards
Christian McCaffrey849ryds - rushing touchdownsChristian McCaffrey8rtd
Depth Charts
| Starter | 2ND | 3RD | 4TH | |
|---|---|---|---|---|
| QB | Brock Purdy | Mac Jones | Kurtis Rourke | |
| RB | Christian McCaffrey | Isaac Guerendo | Jordan James | |
| WR | Jauan Jennings | Jacob Cowing | Skyy Moore | Junior Bergen |
| TE | George Kittle | Luke Farrell | Jake Tonges | Brayden Willis |
| LT | Trent Williams | Spencer Burford | ||
| LG | Ben Bartch | Nick Zakelj | ||
| C | Jake Brendel | Matt Hennessy | Drake Nugent | |
| RG | Dominick Puni | Connor Colby | ||
| RT | Colton McKivitz | Austen Pleasants | ||
| LDE | Nick Bosa | Yetur Gross-Matos | Robert Beal | William Bradley-King |
| RDE | Mykel Williams | Bryce Huff | Sam Okuayinonu | |
| WLB | Dee Winters | Nick Martin | Jalen Graham | |
| MLB | Fred Warner | Luke Gifford | Tatum Bethune | Curtis Robinson |
| LCB | Renardo Green | Jakob Robinson | ||
| SS | Ji'Ayir Brown | Malik Mustapha | Derrick Canteen | |
| FS | Jason Pinnock | Marques Sigle | Siran Neal | |
| RCB | Deommodore Lenoir | Darrell Luter | ||
| P | Thomas Morstead | |||
| PR | Jacob Cowing | Junior Bergen | Jordan Watkins | Ricky Pearsall |
| KR | Isaac Guerendo | Junior Bergen | ||
| LS | Jon Weeks | |||
| DT | Kevin Givens | Alfred Collins | Sebastian Valdez | Evan Anderson |
| FB | Kyle Juszczyk | |||
| RWR | Ricky Pearsall | Jordan Watkins | Malik Turner | |
| LWR | Brandon Aiyuk | Malik Turner | ||
| NT | Jordan Elliott | C.J. West | Kalia Davis | |
| NB | Upton Stout | Chase Lucas |
Team Stats
1989
YDS
3154
246/412
Comps/Atts
307/450
5.706
YPA
7.329
7/6
TDs/INTs
22/13
48/362
Sacks/Yards
20/144
10/21 47.62%
Redzone
30/48 62.5%
47/160 0%
3rd Down
81/168 0%
11/25 0%
4th Down
10/17 0%
Titans vs. 49ers Odds Comparison
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Titans at 49ers Team Totals
MatchupOverUnder | ||
|---|---|---|
Titans 2-11 | N/A | N/A |
49ers 9-4 | N/A | N/A |