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Kentucky vs. Iowa State Odds & Betting Predictions - March 22, 2026

Kentucky at Iowa State

6:49 pm • CBS

Kentucky Wildcats

21-13
22
22 - 20

Iowa State Cyclones

27-7
20

Kentucky at Iowa State Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Kentucky
21-13
+4.5
+5-115
o147-110
+185
Iowa State
27-7
u146
-5-110
u147-110
-225
location pinSunday 6:49 p.m.
March 22, 2026
Enterprise CenterSt. Louis
Kentucky vs. Iowa State Expert Picks
Mike McNamara
Mike McNamara
Last 30d: 101-130-2 (+4.1u)
ISU +105 (Live)
0.4u
Jeremiah Rose
Jeremiah Rose
Last 30d: 15-21-1 (-2.5u)
ISU -120 (Live)
0.2u
Boyd / FanDuel
Allan Lem
Allan Lem
Last 30d: 119-82-2 (+9.8u)
UK +5.5-115
0.58u
Tailing @The_Oddsmaker
Ryan Minion
Ryan Minion
Last 30d: 201-235-2 (-2.5u)
M.Momcilovic o17.5 Pts-125
$1.25
Boomer Betz
Boomer Betz
Last 30d: 116-98-4 (+32.7u)
UK +207
$50.00
Pxpx
Mjaybrod
Mjaybrod
Last 30d: 89-73-1 (+10.9u)
UK +195
0.5u
Outright or lose by 20
The Degenerates
The Degenerates
Last 30d: 112-88-2 (+15.5u)
ISU -5-110
1.1u
Picks Office
Picks Office
Last 30d: 184-200-2 (-29.8u)
UK +5-110
1u
Join Discord. All picks posted before 8am https://discord.gg/HjKxYKdSUy
Mjaybrod
Mjaybrod
Last 30d: 89-73-1 (+10.9u)
Under 146.5-110
1u
Compete to the death
Boomer Betz
Boomer Betz
Last 30d: 116-98-4 (+32.7u)
O.Oweh u23.5 Pts-120
$120.00
CTO
CTO
Last 30d: 23-27-0 (-2.7u)
O.Oweh u20 Pts-101
1u
ISU -5.5-102
2u
Alex Hinton
Alex Hinton
Last 30d: 33-64-1 (-12.3u)
D.Aberdeen o13.5 Pts-115
1u
YBK Picks.com
Last 30d: 30-21-0 (+5.0u)
ISU -5.5-105
2u
Sean Koerner
Sean Koerner
Last 30d: 29-38-2 (-3.1u)
UK +5.5-115
0.58u
Doug Ziefel
Doug Ziefel
Last 30d: 145-151-3 (-7.0u)
UK +5.5-115
0.58u
Vegas Refund
Vegas Refund
Last 30d: 69-70-1 (-7.8u)
ISU -4.5-107
1.07u
Cam Is Money
Cam Is Money
Last 30d: 39-38-1 (-4.1u)
O.Oweh u23.5 Pts-115
1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 68-79-1 (+0.8u)
Under 146.5-110
1.1u
Sandy Plashkes
Sandy Plashkes
Last 30d: 120-124-4 (-17.5u)
C.Chandler o9.5 Pts-104
1.04u
UK +5-110
1.1u
Gilles Gallant
Gilles Gallant
Last 30d: 39-53-1 (-4.9u)
O.Oweh u23.5 Pts-110
0.55u
Action Pro
Brian Bitler
Brian Bitler
Last 30d: 83-92-1 (-33.3u)
UK +5-105
3u
OldSchool0909
Last 30d: 57-51-1 (+2.4u)
UK +190
1u
UK +4.5-102
1u
Boomer Betz
Boomer Betz
Last 30d: 116-98-4 (+32.7u)
C.Chandler o9.5 Pts+170
$100.00
Brandon Kravitz
Brandon Kravitz
Last 30d: 69-89-0 (-10.8u)
UK +5.5-113
1.13u
JMann
JMann
Last 30d: 46-47-0 (+4.5u)
Under 145.5-110
1u
Babs .
Babs .
Last 30d: 107-86-0 (+9.3u)
Under 146.5-115
1u
UK +4.5-102
1u
Kendra Middleton
Kendra Middleton
Last 30d: 5-6-0 (-1.3u)
ISU -4.5-113
1u
Stuck 🚨
Stuck 🚨
Last 30d: 59-75-4 (-0.5u)
UK +5.5-115
0.45u
Some speculation here but don’t think Jefferson plays which would make this a very good number to have in pocket
Boomer Betz
Boomer Betz
Last 30d: 116-98-4 (+32.7u)
UK +5.5-115
$57.50
Half in for now

Kentucky vs. Iowa State Previews & Analysis

  • Kentucky vs Iowa State: Over/Under Pick for Sunday Night article feature image

    Kentucky vs Iowa State: Over/Under Pick for Sunday Night

    Jordan Mann•
    Mar 22, 2026 UTC
  • NCAAB Player Props for Sunday's 2nd-Round Games article feature image

    NCAAB Player Props for Sunday's 2nd-Round Games

    Alex Hinton•
    Mar 22, 2026 UTC
  • +1277 Pace Trend Parlay (Thursday's Hit!) article feature image

    +1277 Pace Trend Parlay (Thursday's Hit!)

    Alex Kolodziej•
    Mar 22, 2026 UTC
  • Solid Edge on This Total & More Sunday March Madness Bets article feature image

    Solid Edge on This Total & More Sunday March Madness Bets

    Action Network Staff•
    Mar 22, 2026 UTC
See more NCAAB Coverage Right Arrow

Prop Odds Comparison

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No props found

Line Movement Tracker

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Kentucky vs. Iowa State Public Betting Percentages

Away Logo

Kentucky

Public

Home Logo

Iowa State

44%

Bets%

56%

Money%

NCAAB Public Betting Right Arrow

Betting Trends

  • Iowa State are 3-2 in their last 5 games.
  • Iowa State are 4-1 in their last 5 games against the spread
  • Iowa State are 8-5 in their road games against the spread
  • The totals have gone OVER in 2 of Iowa State' last 5 games
  • The totals have gone OVER in 12 of Iowa State' 21 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Iowa State		20-1412-98-515-92-1
Kentucky		17-1710-127-57-86-6

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Iowa State		14-19-112-92-10-18-15-11-2
Kentucky		17-1711-116-67-85-7

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Iowa State		27-7N/AN/A19-51-2
Kentucky		21-13N/AN/A11-43-9

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Mar 20thTNSTW 108-74-25 WO 147.5ISU -10000
Mar 13th@ARIZL 80-82+3 WO 144.5ARIZ +142
Mar 12th@TTUW 75-53-7 WU 143.5ISU -298
Mar 11thASUW 91-42-13.5 WU 148.5ISU -1200
Mar 7thASUW 86-65-16.5 WO 148.5ISU -2100

Iowa State vs. Kentucky Injury Updates

Iowa State Injuries

  • Joshua Jefferson
    F

    Jefferson is out with ankle

    Out

  • Xzavion Mitchell
    F

    Mitchell is questionable with undisclosed

    Questionable

Kentucky Injuries

  • Jaland Lowe
    G

    Lowe is out for season with arm

    Out for Season

  • Jayden Quaintance
    F

    Quaintance is out with knee

    Out

See more NCAAB Injuries Right Arrow
Team Stats

9-16 (56%)
Field Goals
6-19 (32%)
0-1 (0%)
Free Throws
8-11 (73%)
4-9 (44%)
3P
0-9 (0%)
11
Rebounds
9
5
Assists
3
8
Turnovers
3
1
Steals
4
0
Blocks
0
7
Fouls
5

Kentucky vs. Iowa State Odds Comparison

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Kentucky at Iowa State Team Totals

MatchupOverUnder
Kentucky
21-13
N/A
N/A
Iowa State
27-7
N/A
N/A