Bills vs. Browns Odds & Betting Predictions - December 21, 2025

Bills at Browns

6:00 pm • CBS

Buffalo Bills

@

Cleveland Browns

MatchupOpenSpreadTotalMoneyline
Bills 8-4	N/A	N/A	N/A
Browns 3-9	N/A	N/A	N/A

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Sunday 6:00 p.m.

December 21, 2025

Huntington Bank FieldCleveland

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NFL Public Betting

Browns are 1-4 in their last 5 games.
Browns are 2-3 in their last 5 games against the spread
Browns are 1-5 in their road games against the spread
The totals have gone OVER in 1 of Browns' last 5 games
The totals have gone OVER in 2 of Browns' 5 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Browns	5-7	4-1	1-5	1-1	4-6
Bills	6-6	3-3	3-3	4-6	2-0

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Browns	6-6	2-3	3-3	2-0	4-6
Bills	5-7	4-2	1-5	4-6	1-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Browns	3-9	N/A	N/A	1-1	2-8
Bills	8-4	N/A	N/A	6-4	2-0

date	opponent	score	spread	over/under	moneyline
Nov 30th	SF	L 8-26	+5.5 L	U 35.5	SF +205
Nov 23rd	@LV	W 24-10	+3 W	U 36.5	CLE +140
Nov 16th	BAL	L 16-23	+7.5 W	O 37.5	BAL +345
Nov 9th	@NYJ	L 20-27	-2 L	O 37.5	NYJ -130
Oct 26th	@NE	L 13-32	+7 L	O 40.5	NE +275

DeAndre Carter
WR
Carter is out with knee
Out
Brenden Bates
TE
Bates is out with ankle
Out

Dylan Sampson
RB
Sampson is questionable with calf
Questionable

Curtis Samuel
WR
Samuel is out with elbow
Out
Mecole Hardman
WR
Hardman is out with calf
Out
Tyler Bass
K
Bass is out with hip
Out
Joshua Palmer
WR
Palmer is questionable with ankle
Questionable
Dalton Kincaid
TE
Kincaid is questionable with hamstring
Questionable

See more NFL Injuries

passing yards
Dillon Gabriel
937
pyds
passing touchdowns
Dillon Gabriel
7
ptd
rushing yards
Quinshon Judkins
758
ryds
rushing touchdowns
Quinshon Judkins
7
rtd

	Starter	2ND	3RD	4TH
QB	Dillon Gabriel	Shedeur Sanders	Deshaun Watson
RB	Jerome Ford	Quinshon Judkins	Dylan Sampson
WR	Jamari Thrash	DeAndre Carter	Gage Larvadain
TE	David Njoku	Harold Fannin	Blake Whiteheart	Brenden Bates	Sal Cannella
LT	Dawand Jones	Cornelius Lucas
LG	Joel Bitonio	Teven Jenkins
C	Ethan Pocic	Luke Wypler
RG	Wyatt Teller	Zak Zinter
RT	Jack Conklin
LDE	Alex Wright	Isaiah McGuire	Julian Okwara	K.J. Henry
RDE	Myles Garrett	Cameron Thomas
WLB	Devin Bush	Jerome Baker	Winston Reid
MLB	Carson Schwesinger	Mohamoud Diabate	Easton Mascarenas-Arnold
LCB	Denzel Ward	Dom Jones
SS	Grant Delpit	Rayshawn Jenkins	Donovan McMillon
FS	Ronnie Hickman	Christopher Edmonds
P	Corey Bojorquez
H	Corey Bojorquez
PR	DeAndre Carter	Gage Larvadain	Kaden Davis
KR	DeAndre Carter	Kaden Davis
LS	Rex Sunahara
LWR	Cedric Tillman
DT	Mason Graham	Mike Hall	Sam Kamara
NT	Maliek Collins	Shelby Harris	Adin Huntington
RWR	Jerry Jeudy	Isaiah Bond	Kaden Davis
K	Andre Szmyt
NB	Myles Harden

Total

Passing

2704

YDS

1914

246/356

Comps/Atts

234/406

8.107

YPA

5.313

19/10

TDs/INTs

11/10

28/182

Sacks/Yards

33/243

Rushing

1868

Rush Yards

1182

376

Attempts

305

4.968

YPC

3.875

21

TDs

8

Turnovers

Fumbles Lost

10

Interceptions

10

Efficiency

26/42 61.91%

Redzone

15/28 53.57%

66/149 0%

3rd Down

52/168 0%

10/17 0%

4th Down

11/25 0%

First Downs

264

Total

193

139

Pass

93

100

Rush

74

25

Penalty

26

Misc

/

Penalties/Yards

/

Possession

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MatchupOverUnder
Bills 8-4	N/A	N/A
Browns 3-9	N/A	N/A