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Broncos vs. Chargers Odds & Betting Predictions - September 21, 2025

Broncos at Chargers

8:05 pm • CBS

Denver Broncos

1-2
20
20 - 23

Los Angeles Chargers

3-0
23

Broncos at Chargers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Broncos
1-2
+2.5
+2.5+100
o45.5-110
+130
Chargers
3-0
u43.5
-2.5-121
u45.5-107
-155
location pinSunday 8:05 p.m.
September 21, 2025
SoFi StadiumInglewood
Broncos vs. Chargers Expert Picks
Boomer Betz
Boomer Betz
Last 30d: 123-109-1 (+22.8u)
DEN +3 (Live)+100
1u
Austin Pendergrass
Austin Pendergrass
Last 30d: 55-47-0 (+0.4u)
LAC -142 (Live)
0.35u
Gilles Gallant
Gilles Gallant
Last 30d: 17-52-0 (-6.2u)
B.Nix Anytime TD Scorer Yes+460
0.5u
Ryan Sura
Ryan Sura
Last 30d: 91-84-2 (+9.9u)
L.McConkey o69.5 Rec Yds+115
1u
Shady Biev
Shady Biev
Last 30d: 46-54-1 (-4.8u)
J.Dobbins Anytime TD Scorer Yes+145
2.18u
Sandy Plashkes
Sandy Plashkes
Last 30d: 64-95-3 (-20.8u)
L.McConkey o65.5 Rec Yds-114
1.71u
Mjaybrod
Mjaybrod
Last 30d: 57-71-2 (-8.5u)
DEN +3-110
1u
Colorado Kush
Boomer Betz
Boomer Betz
Last 30d: 123-109-1 (+22.8u)
DEN +130
0.5u
The Degenerates
The Degenerates
Last 30d: 70-71-2 (-8.1u)
DEN +3-120
1.2u
DEN +130
1u
The Propfessor
The Propfessor
Last 30d: 34-53-1 (+2.3u)
J.Herbert o20.5 Rush Yds-115
1u
Vegas Refund
Vegas Refund
Last 30d: 33-30-2 (-0.2u)
DEN +3-115
1.15u
Matt DiLeo
Matt DiLeo
Last 30d: 41-30-0 (+4.3u)
Both Teams To Make 33+ Yard FG-120
0.42u
Capper Central
Capper Central
Last 30d: 100-62-1 (+22.2u)
DEN +3-115
1.15u
Matthew Freedman
Matthew Freedman
Last 30d: 29-37-0 (-6.9u)
Q.Johnston Anytime TD Scorer Yes+230
0.5u
Projection: +165. For more, check out the Fantasy Life player projections.
B.Nix o0.5 Int-138
0.69u
Projection: -192. For more, check out the Fantasy Life player projections.
Sean Zerillo
Sean Zerillo
Last 30d: 151-176-4 (-11.1u)
LAC -2.5-111
0.25u
All NFL Sides + Totals bet on exchanges at significantly better odds
Shady Biev
Shady Biev
Last 30d: 46-54-1 (-4.8u)
DEN +3-115
1.73u
Matt DiLeo
Matt DiLeo
Last 30d: 41-30-0 (+4.3u)
C.Dicker o1.5 FGs Made-130
0.77u
Roger Goodell
Roger Goodell
Last 30d: 32-26-1 (+1.8u)
LAC -2.5-120
0.83u
Lock & Cash
Lock & Cash
Last 30d: 11-11-0 (-0.2u)
LAC -2.5-110
1.36u
💰🦡 Jake
💰🦡 Jake
Last 30d: 93-112-8 (+31.0u)
LAC -2.5-120
1u
Charlie Wright
Charlie Wright
Last 30d: 6-10-0 (-4.4u)
J.Herbert o19.5 Rush Yds-140
1.4u
Herbert is off to an excellent this start this season, largely due to an adjustment in offensive mindset for the Chargers. They lead the league in pass rate over expectation through 2 games and are 5th in neutral pass rate. The ground-and-pound nature of this team under Jim Harbaugh and Greg Roman has given way to an aerial attack. The increase in passing plays has boosted Herbert's production on the ground. He's posted 16 carries for 63 yards. After recording 7+ carries in just 2 games last season, he's done it in both games to begin this season. Herbert averaged 1.8 scrambles per game last season. He's up to 3.5 per game so far this season. Herbert has 30+ rushing yards in each game. Denver has played man coverage at the 2nd-highest rate this season. They were 5th last season. Man coverage typically leads to more scramble opportunities, as the defensive backs are focused on their assignments and not looking at the quarterback.
Firefighter Bets
Firefighter Bets
Last 30d: 156-162-0 (-14.4u)
T.Hufanga o6.5 Tackles + Ast+100
1u
Chris Raybon
Chris Raybon
Last 30d: 20-17-1 (+14.0u)
DEN +3-115
1.15u
0-2 ATS dogs in Week 3 63-39 (62%) ATS since ‘05, including 21-5 (81%) in Division.
Grant Neiffer
Grant Neiffer
Last 30d: 40-142-9 (-0.6u)
Q.Johnston Anytime TD Scorer Yes+250
0.5u
Brandon Kravitz
Brandon Kravitz
Last 30d: 33-43-0 (-10.8u)
DEN +2.5+100
1u
Week 3 fade of a team we’ve probably slightly overrated off 2 wins. The Chargers beat a Chiefs team that can’t move the ball and the Raiders. Off a short week against a division rival, this should be closer to -1/-1.5.
Gilles Gallant
Gilles Gallant
Last 30d: 17-52-0 (-6.2u)
Q.Johnston Anytime TD Scorer Yes+275
1u
Betting him every game at this price.
Markus Markets
Markus Markets
Last 30d: 21-27-2 (-0.6u)
L.McConkey 5+ Receptions Yes-150
1.5u
The Favorites Podcast
The Favorites Podcast
Last 30d: 7-11-0 (-3.6u)
L.McConkey Anytime TD Scorer Yes+160
1u
@KendraMiddleton_ https://myaction.app/n9oxUJkKLWb
Derek Carty
Derek Carty
Last 30d: 11-15-0 (-1.9u)
N.Harris u7.5 Rush Att+112
1.12u
THE BLITZ is forecasting 6.42 rush attempts for Najee Harris compared to 8.75 rush attempts implied by sportsbooks, so I believe there is some value here. If you take the under, you’d be projected to win 69% of the time, resulting in a 45% ROI. Based on a $100 wager, the expected value here would be $45.33. Love THE BLITZ? Get all of Carty’s sports betting projections at https://evanalytics.com/products/nfl-premium-subscription?ref=inf8qq%22%3EEV Analytics!
Kendra Middleton
Kendra Middleton
Last 30d: 7-5-0 (+1.4u)
L.McConkey Anytime TD Scorer Yes+160
1u
Kenny Ducey
Kenny Ducey
Last 30d: 30-21-1 (+7.7u)
Under 45.5-110
1u
Greg Matherne
Greg Matherne
Last 30d: 24-27-1 (+6.2u)
DEN +3-120
0.6u
Kyle Murray
Kyle Murray
Last 30d: 44-51-3 (-3.7u)
L.McConkey o50.5 Rec Yds-110
1.1u
J.Herbert o235.5 Pass Yds-110
2u
Boomer Betz
Boomer Betz
Last 30d: 123-109-1 (+22.8u)
DEN +2.5+103
1u
FTN Fantasy
FTN Fantasy
Last 30d: 74-91-0 (-24.4u)
DEN +2.5+100
1u

Broncos vs. Chargers Previews & Analysis

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    NFL Player Props: 8 Picks for Week 3

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  • Anytime Touchdown Picks for Every NFL Game article feature image

    Anytime Touchdown Picks for Every NFL Game

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See more NFL Coverage Right Arrow

Broncos vs. Chargers Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Broncos vs. Chargers Public Betting Percentages

Away Logo

Broncos

Public

Home Logo

Chargers

43%

Bets%

57%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Chargers are 3-0 in their last 5 games.
  • Chargers are 3-0 in their last 5 games against the spread
  • Chargers are 1-0 in their road games against the spread
  • The totals have gone OVER in 1 of Chargers' last 3 games
  • The totals have gone OVER in 0 of Chargers' 1 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Chargers		3-01-01-02-01-0
Broncos		0-30-10-20-20-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Chargers		1-20-10-10-21-0
Broncos		1-20-11-11-10-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Chargers		3-0N/AN/A2-01-0
Broncos		1-2N/AN/A1-10-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 16th@LVW 20-9-3.5 WU 46.5LAC -190
Sep 6thKCW 27-21+3 WO 47.5LAC +145
Aug 24th@SFL 23-30-2.5 LO 35.5SF -152
Aug 16th@LAL 22-23-8 LO 39.5LA -375
Aug 10thNOW 27-13-2.5 WO 39LAC -140

Broncos vs. Chargers Injury Updates

Broncos Injuries

  • Evan Engram
    TE

    Engram is questionable with back

    Questionable

  • Dre Greenlaw
    LB

    Greenlaw is out with quad

    Out

  • Malcolm Roach
    DT

    Roach is out with calf

    Out

Chargers Injuries

  • Will Dissly
    TE

    Dissly is doubtful with knee

    Doubtful

  • Najee Harris
    RB

    Harris is out with achilles

    Out

See more NFL Injuries Right Arrow
Team Stats

Total

265
Total Yards
376
48
Total Plays
80
5.5
Yards Per Play
4.7

Passing

153
YDS
300
14/25
Comps/Atts
28/47
5.444
YPA
5.192
1/0
TDs/INTs
1/1
2/6
Sacks/Yards
5/30

Rushing

118
Rush Yards
106
21
Attempts
28
5.619
YPC
3.786
1
TDs
1

Turnovers

0
Fumbles Lost
1
0
Interceptions
1

Efficiency

1/2 50%
Redzone
1/3 33.33%
2/13 0%
3rd Down
8/17 0%
2/2 0%
4th Down
0/0 0%

First Downs

9
Total
29
5
Pass
17
3
Rush
6
1
Penalty
6

Misc

10/90
Penalties/Yards
3/25
23:40
Possession
36:20

Broncos vs. Chargers Odds Comparison

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Broncos at Chargers Team Totals

MatchupOverUnder
Broncos
1-2
o21.5-110
u21.5-112
Chargers
3-0
o23.5-124
u23.5+102