Panthers vs. Cardinals Odds & Betting Predictions - September 14, 2025

Meant to be full unit bet.

K. Murray ⬇️ 0.5 Interceptions (-139 @ DraftKings)(ARI) Kyler looked good last week. He usually has a few plays where you are left scratching your head, but he avoided them in week 1. In his last 20 games, Murray avoided throwing an interception in 11 of them. Even though he did throw one against CAR late last season, I still like this matchup for him. In week 1, Murray did not throw an interception AND did not even have one turnover-worthy play. That essentially means he didn't throw a pass that could have been picked, which is encouraging. He now runs up against another weak defense, where he honestly might not have to throw much at all. Last season CAR forced the 7th lowest turnover-worthy play rate (2.3%). Last season, Kyler ranked 10th lowest in turnover-worthy throw rate (2.2%) of QB's with at least 10 games. Not only did the CAR offense look awful again, especially the run defense, but the offense seemingly reverted back to it's early 2024 self. That could help create a early positive game script in this one. Given they are weak against the run, I wouldn't be surprised to see ARI lean heavily on that. That'll create less chances for Murray to turn over the ball.

Projection: -8.5. For more, check out the Fantasy Life game model.

Tailing @The_Oddsmaker

Wilson’s Week 1 box score (1/5/0) looks worse than it should have. He had 56 air yards on 4 targets, 2nd most on the team, and probably should have walked away with 2 catches for 20+ yards. I do expect him to bounce back with a line closer to that here, but this market still exposes his lower floor. Zay Jones, who Arizona traded for last year, had a much bigger role right out of the gate than he saw in 2024, which was expected based on late camp reports. Specifically, Jones played more in 2WR sets. In a game where the Cardinals are likely to play with a lead and lean on the run against a weak Panthers defense, we could see fewer 3-4 WR sets, which cuts into Wilson’s opportunities. On top of that, Marvin Harrison Jr. and Trey McBride should both see higher target rates going forward. With Tip Reiman out, Arizona is likely to use Elijah Higgins more, and Higgins commands a higher target rate than Reiman. That could siphon an extra look away from Wilson. Even if the Cardinals dial up another 4 throws Wilson’s way at his 14.8-yard aDOT, it’s unlikely he hauls in 3+ here. I have him projected closer to 2.2 receptions with about a 62% chance to stay under 2.5.

This is my favorite prop of the week. The Panthers defense looked terrible in Week 1, maybe as bad as they were last season — especially the run D. Remember, this is the defense that was last in the league in DVOA last season, including dead last against the run by a mile. If you magically combined opposing RBs to face Carolina last season into one player, that player had by far the greatest statistical season in NFL history: 486 carries for 2,520 yards and 18 TDs. Only one other team even allowed over 2,000 yards on the ground to RBs. Jacksonville hasn't run the ball well for years. The Jaguars play the Panthers in Week 1 and, voila! Travis Etienne rips off 143 yards on 16 carries. This could be a breakout game for Drew Petzing's offense, and you always want James Conner overs in games you expect Arizona to win. Conner averaged 92 rushing yards per game with 10 TDs in 11 wins the last two seasons, compared to just 62 YPG with eight TDs in 18 losses. Those are stark contrasts, which means playing Conner overs can act as a proxy for a Cardinals win. I love Conner to go over 60.5 rushing yards (-115, Caesars). He had 98+ rushing yards in seven of those 11 wins the last two years, so we should place a sizable portion of our bet on 100+ yards too at +500 (bet365). Touchdown bettors will see a green light here at -135, with Conner finding the end zone in seven of those 11 wins. I don't mind that but I'll just nibble the huge game outcome of 100+ yards and two scores at +1600 (bet365) and hope for a monster Conner game.

@wheatonbrando https://myaction.app/wBCiOGTOBWb

@kendrajmiddleton0_ https://myaction.app/cNgs6OL8zWb

Favorite ATD @Stuckey2 https://myaction.app/ZxcCww53zWb

Sneaky sneaky

Early 2U guy. This total was 47.5 last year at Carolina outdoors in December and soared over. Defenses upgraded a bit i suppose, not enough. Don’t expect either team to get much pressure so think both Kyler and Bryce should be better vs an easier unit than what they saw last week. Week 2 overs after both teams went under are money, especially indoors. Ultimately, this is just too low

Not into either defense here, so willing to bet the over despite both offenses' middling performances in Week 1.