Padres vs. Cubs Odds & Betting Predictions - October 1, 2025

Padres at Cubs

7:08 pm • ABC
3 - 0
Starting Pitchers
pitcherteameraw-l
Andrew Kittredge logoA.KittredgeChicago Cubs logo0.000-0
Dylan Cease logoD.CeaseSan Diego Padres logo0.000-0

Padres at Cubs Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Padres
1-1
-1.5
-1.5+163
o6.5-111
-111
Cubs
1-1
u7
+1.5-203
u6.5-107
-110
location pinWednesday 7:08 p.m.
October 01, 2025
Wrigley FieldChicago
Padres vs. Cubs Expert Picks
Boomer Betz
Boomer Betz
Last 30d: 123-106-2 (+20.6u)
CHC +148 (Live)
1u
Scott Rickenbach
Scott Rickenbach
Last 30d: 52-50-2 (-6.2u)
Over 6.5 (Live)-116
1u
VegasIsMyBitch
VegasIsMyBitch
Last 30d: 9-16-0 (-4.0u)
Under 6.5-105
0.95u
Kyle Murray
Kyle Murray
Last 30d: 53-50-3 (+7.5u)
Under 3.5 (F5)-125
1u
The Degenerates
The Degenerates
Last 30d: 75-64-2 (+5.8u)
Under 6.5-110
1u
Kyle Murray
Kyle Murray
Last 30d: 53-50-3 (+7.5u)
D.Cease u5.5 Ks+112
1.12u
CHC -115
1.15u
Allan Lem
Allan Lem
Last 30d: 113-113-8 (-4.3u)
Under 6.5+100
1u
Both bullpens are above-average and I’m expecting Imanaga to come in as the bulk pitcher for Chicago to help against the lefties in the bottom of the lineup. Padres facing elimination so should be a quick hook for Cease if he’s ineffective or runs into trouble. Winds projected to be blowing in. All these factors have me on the Under 6.5 here.
Charlie Wright
Charlie Wright
Last 30d: 15-12-0 (+1.8u)
A.Kittredge u0.5 Ks+205
1u
Since getting traded to Chicago, Kittredge has made 23 appearances. All of them were 1 inning or less. He pitched in Game 1, covering a single inning. Kittredge has bumped his strikeout rate to a career-high 30.8% by spamming his slider. He's thrown the pitch 52.9% of the time, and it has an excellent 40.3% whiff rate. San Diego makes a ton of contact. They had the 3rd-lowest K% vs. RHP in the regular season. Tatis (18.9% K% against RHP this season), Luis Arraez (2.3%), and Manny Machado (19.5%) will be the first three hitters in the lineup. Their strikeout numbers against specifically right-handed sliders are in line with their season-long marks, so they shouldn't be overly susceptible to Kittredge's main pitch.
Kenny Ducey
Kenny Ducey
Last 30d: 29-25-2 (+2.3u)
CHC -116
1.16u
Obligatory Cease fade
YBK Picks.com
Last 30d: 42-38-2 (+2.4u)
Under 6.5-115
1.74u
💰🦡 Jake
💰🦡 Jake
Last 30d: 100-123-6 (+29.3u)
SD o3.5+124
1u
Lines at Lunch
Lines at Lunch
Last 30d: 94-92-3 (-4.4u)
Over 3.5 (F5)+105
0.95u
Ryan Sura
Ryan Sura
Last 30d: 100-95-2 (+6.7u)
Over 3.5 (F5)+105
1u
Lines at Lunch
Lines at Lunch
Last 30d: 94-92-3 (-4.4u)
SD -102
1u
Payoff Pitch Podcast
Payoff Pitch Podcast
Last 30d: 65-77-6 (+8.9u)
CHC -110
1u
@Zerillo
D.Cease u14.5 Outs-115
0.87u
@Zerillo @cowhitchurch https://myaction.app/irmZJtM46Wb
Cam Is Money
Cam Is Money
Last 30d: 56-70-3 (-13.3u)
CHC -113
1u
Sean Zerillo
Sean Zerillo
Last 30d: 149-175-5 (-13.2u)
D.Cease u14.5 Outs-141
0.1u
Bet to -155
Lines at Lunch
Lines at Lunch
Last 30d: 94-92-3 (-4.4u)
SD +102
1u
Brian Bitler
Brian Bitler
Last 30d: 74-73-1 (-5.5u)
CHC -112
3u
Anders
Anders
Last 30d: 11-14-0 (-2.6u)
CHC -106
1.06u
Analysis on Tiktok… I’d play to -120
Brandon Kravitz
Brandon Kravitz
Last 30d: 45-54-0 (-5.4u)
Under 6.5+100
1u
Sandy Plashkes
Sandy Plashkes
Last 30d: 75-104-3 (-10.5u)
SD +102
1.02u
Sean Zerillo
Sean Zerillo
Last 30d: 149-175-5 (-13.2u)
CHC -104
1.04u
Bet to -115

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Prop Odds Comparison

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Line Movement Tracker

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Padres vs. Cubs Public Betting Percentages

Away Logo

Padres

Public

46%

Bets%

54%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cubs
79-8336-4543-3833-5045-32
Padres
82-7835-4547-3343-5737-19

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cubs
75-81-634-46-141-35-540-39-434-41-2
Padres
81-74-544-34-237-40-351-44-528-28

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cubs
92-7044-3739-4245-3837-40
Padres
4-345-3547-3358-4231-25

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 30thSDW 3-1-1.5 WU 6.5CHC -133
Sep 28thSTLW 2-0-1.5 WU 7CHC -155
Sep 27thSTLW 7-3-1.5 WO 9.5CHC -178
Sep 26thSTLW 12-1-1.5 WO 9CHC -184
Sep 25thNYML 5-8+1.5 LO 7.5NYM -103

Cubs vs. Padres Injury Updates

Cubs Injuries

  • Michael Soroka
    SP

    Soroka is out with shoulder

    Out

  • Justin Steele
    SP

    Steele is out for season with elbow

    Out for Season

Padres Injuries

  • Joseph Musgrove
    SP

    Musgrove is out for season with elbow

    Out for Season

Padres vs. Cubs Box Score
Padres Player Stats
Projected
PITCHERPCIPKER
Dylan Cease logoRD.Cease, P693.250
Adrian Morejon logoLA.Morejon, P332.110
Mason Miller logoRM.Miller, P271.250
Robert Suarez logoRR.Suarez, P181.100
HITTERSH-ABRHRRBI
Fernando Tatis logo1F.Tatis, RF1-4200
Luis Arraez logo2L.Arraez, 1B2-3000
Manuel Machado logo3M.Machado, 3B1-4112
Jackson Merrill logo4J.Merrill, CF0-2001
Xander Bogaerts logo5X.Bogaerts, SS1-4000
Ryan O'Hearn logo6R.O'Hearn, DH1-3000
Gavin Sheets logo7G.Sheets, LF0-1000
Jose Iglesias logo7J.Iglesias, PH0-1000
Bryce Johnson logo7B.Johnson, LF0-2000
Jacob Cronenworth logo8J.Cronenworth, 2B0-4000
Freddy Fermin logo9F.Fermin, C1-4000
Cubs Player Stats
Projected
PITCHERPCIPKER
Andrew Kittredge logoRA.Kittredge, P20111
Shota Imanaga logoLS.Imanaga, P67432
Caleb Thielbar logoLC.Thielbar, P140.210
Colin Rea logoRC.Rea, P151.210
Taylor Rogers logoLT.Rogers, P13100
Michael Soroka logoRM.Soroka, P60.200
HITTERSH-ABRHRRBI
Michael Busch logo1M.Busch, 1B0-3000
Nicholas Hoerner logo2N.Hoerner, 2B1-4000
Ian Happ logo3I.Happ, LF0-4000
Kyle Tucker logo4K.Tucker, DH1-4000
Seiya Suzuki logo5S.Suzuki, RF1-4000
Carson Kelly logo6C.Kelly, C0-2000
Peter Crow-Armstrong logo7P.Crow-Armstrong, CF0-3000
Dansby Swanson logo8D.Swanson, SS1-3000
Matthew Shaw logo9M.Shaw, 3B0-2000
Moises Ballesteros logo9M.Ballesteros, PH0-1000
Willi Castro logo9W.Castro, 3B0-0000

Padres vs. Cubs Odds Comparison

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Padres at Cubs Team Totals

MatchupOverUnder
Padres
1-1
o3.5+115
u3.5-146
Cubs
1-1
o2.5-160
u2.5+124