Turn your sports knowledge into winning predictions
21+ or 18+ in Certain Locations. 19+ in ON. Please Play Responsibly. Gambling Problem? Call 1-800-GAMBLER. Visit connexontario.ca or Call 1-866-531-2600 in ON.
No Code Needed

Bills vs. Panthers Odds & Betting Predictions - October 26, 2025

Bills at Panthers

5:00 pm • FOX

Buffalo Bills

4-0
@

Carolina Panthers

1-3

Bills at Panthers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Bills
4-0
N/A
N/A
N/A
Panthers
1-3
N/A
N/A
N/A
location pinSunday 5:00 p.m.
October 26, 2025
Bank of America StadiumCharlotte

Bills vs. Panthers Props

Prop Projections

See All
Right Arrow

There are no prop projections found for the selected slate. Please check back later.

Prop Odds Comparison

Right Arrow
Right Arrow

No props found

Line Movement Tracker

Right Arrow
Right Arrow

Bills vs. Panthers Public Betting Percentages

Away Logo

Bills

Public

Home Logo

Panthers

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Panthers are 1-3 in their last 5 games.
  • Panthers are 2-2 in their last 5 games against the spread
  • Panthers are 1-2 in their road games against the spread
  • The totals have gone OVER in 2 of Panthers' last 4 games
  • The totals have gone OVER in 0 of Panthers' 1 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Panthers		2-21-01-2N/A2-2
Bills		2-21-21-01-21-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Panthers		2-20-12-1N/A2-2
Bills		3-13-00-12-11-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Panthers		1-3N/AN/AN/A1-3
Bills		4-0N/AN/A3-01-0

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 28th@NEL 13-42+5.5 LO 42.5NE +200
Sep 21stATLW 30-0+4.5 WU 44CAR +185
Sep 14th@ARIL 22-27+7 WO 45.5ARI +265
Sep 7th@JACL 10-26+4.5 LU 45.5JAC +184
Aug 21stPITL 10-19+6.5 LU 34.5PIT +235

Bills vs. Panthers Injury Updates

Bills Injuries

  • Tyler Bass
    K

    Bass is out with hip

    Out

Panthers Injuries

  • David Moore
    WR

    Moore is doubtful with elbow

    Doubtful

  • Ikem Ekwonu
    T

    Ekwonu is doubtful with illness

    Doubtful

  • Damarri Mathis
    CB

    Mathis is out with knee

    Out

  • Xavier Legette
    WR

    Legette is out with hamstring

    Out

  • Ja'Tavion Sanders
    TE

    Sanders is out with ankle

    Out

  • Jalen Coker
    WR

    Coker is out with quad

    Out

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Bryce Young logo
    Bryce Young
    753
    pyds
  • passing touchdowns
    Bryce Young logo
    Bryce Young
    5
    ptd
  • rushing yards
    Chuba Hubbard logo
    Chuba Hubbard
    217
    ryds
  • rushing touchdowns
    Rico Dowdle logo
    Rico Dowdle
    1
    rtd
Depth Charts
Right Arrow
Starter2ND3RD4TH
QBBryce YoungAndy Dalton
RBChuba HubbardRico DowdleTrevor Etienne
WRJimmy HornHunter Renfrow
TEJa'Tavion SandersMitchell EvansJames MitchellBryce Pierre
LTIkem EkwonuBrady ChristensenMichael Tarquin
LGDamien LewisJarrett Kingston
CAustin CorbettCade Mays
RGRobert HuntChandler Zavala
RTTaylor MotonYosh NijmanBrandon Walton
LDEDerrick BrownLaBryan RayJaden Crumedy
RDETershawn WhartonA'Shawn RobinsonJared Harrison-Hunte
LCBMike Jackson
SSTre'von MoehrigLathan Ransom
FSNick ScottDemani Richardson
RCBJaycee HornCorey ThorntonAkayleb Evans
PSam Martin
HSam Martin
PRTrevor EtienneJimmy HornDavid Moore
KRJimmy HornTrevor EtienneDavid Moore
LSJJ Jansen
LWRTetairoa McMillanDavid MooreBrycen Tremayne
NTBobby BrownCam Jackson
RWRXavier LegetteJalen CokerJa'seem Reed
ROLBD.J. WonnumNic ScourtonDJ Johnson
NBChau Smith-WadeMichael ReidTrevian Thomas
LOLBPatrick JonesPrincely UmanmielenThomas IncoomBoogie Basham
RILBChristian RozeboomMapalo Mwansa
LILBTrevin WallaceClaudin CherelusKrys BarnesBam Martin-Scott
KRyan Fitzgerald
Team Stats

Passing

962
YDS
756
86/123
Comps/Atts
92/150
8.098
YPA
5.407
7/1
TDs/INTs
6/3
7/34
Sacks/Yards
6/55

Rushing

654
Rush Yards
401
133
Attempts
102
4.917
YPC
3.931
9
TDs
2

Turnovers

Fumbles Lost
1
Interceptions
3

Efficiency

12/18 66.67%
Redzone
7/10 70%
21/50 0%
3rd Down
21/55 0%
3/4 0%
4th Down
6/11 0%

First Downs

97
Total
77
49
Pass
45
38
Rush
24
10
Penalty
8

Misc

/
Penalties/Yards
/
Possession

Bills vs. Panthers Odds Comparison

Right Arrow

Could not load odds

See more NFL Odds Right Arrow

Bills at Panthers Team Totals

MatchupOverUnder
Bills
4-0
N/A
N/A
Panthers
1-3
N/A
N/A