Patriots vs. Bills Odds & Betting Predictions - October 6, 2025

Patriots at Bills

12:20 am • NBC

New England Patriots

Buffalo Bills

MatchupOpenSpreadTotalMoneyline
Patriots 2-2	+8.5	+8-111	o50-110	+322
Bills 4-0	u46.5	-8-109	u50-111	-417

Monday 12:20 a.m.

October 06, 2025

Highmark StadiumOrchard Park

66°Fahrenheit

0%Rain

3Wind

Over 50.5-105

Have this total at 54. Neither defense has impressed yet, and both offenses have been efficient. Weather looks good in Buffalo on Sunday night, as well.

BUF o29.5 Team Total-103

NE +8.5-112

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Sep 30, 2025 UTC

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NFL Public Betting

Bills are 4-0 in their last 5 games.
Bills are 2-2 in their last 5 games against the spread
Bills are 1-0 in their road games against the spread
The totals have gone OVER in 3 of Bills' last 4 games
The totals have gone OVER in 3 of Bills' 3 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Bills	2-2	1-2	1-0	1-2	1-0
Patriots	2-2	1-2	1-0	1-1	1-1

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Bills	3-1	3-0	0-1	2-1	1-0
Patriots	2-2	1-2	1-0	1-1	1-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Bills	4-0	N/A	N/A	3-0	1-0
Patriots	2-2	N/A	N/A	1-1	1-1

date	opponent	score	spread	over/under	moneyline
Sep 28th	NO	W 31-19	-14.5 L	O 48.5	BUF -1500
Sep 19th	MIA	W 31-21	-11.5 L	O 50.5	BUF -800
Sep 14th	@NYJ	W 30-10	-6 W	U 47.5	BUF -290
Sep 8th	BAL	W 41-40	+1.5 W	O 51.5	BUF +105
Aug 23rd	@TB	W 23-19	-1.5 W	O 37.5	BUF -125

Charles Woods
CB
Woods is questionable with concussion
Questionable

Tyler Bass
K
Bass is out with hip
Out

See more NFL Injuries

passing yards
Josh Allen
964
pyds
passing touchdowns
Josh Allen
7
ptd
rushing yards
James Cook
401
ryds
rushing touchdowns
James Cook
5
rtd

	Starter	2ND	3RD	4TH
QB	Josh Allen	Mitchell Trubisky	Shane Buechele
RB	James Cook	Ray Davis	Ty Johnson	Frank Gore
WR	Khalil Shakir	Elijah Moore	Stephen Gosnell
TE	Dalton Kincaid	Dawson Knox	Jackson Hawes	Keleki Latu
LT	Dion Dawkins	Tylan Grable	Chase Lundt	Travis Clayton
LG	David Edwards	Kendrick Green
C	Connor McGovern	Sedrick Van Pran-Granger
RG	O'Cyrus Torrence	Alec Anderson
RT	Spencer Brown	Ryan Van Demark
LDE	Greg Rousseau	Landon Jackson	Javon Solomon
WLB	Matt Milano	Dorian Williams	Keonta Jenkins
MLB	Terrel Bernard	Joe Andreessen	Shaq Thompson	Jimmy Ciarlo
LCB	Christian Benford	Maxwell Hairston	Dorian Strong
SS	Cole Bishop	Cam Lewis	Wande Owens
FS	Taylor Rapp	Damar Hamlin	Jordan Hancock
RCB	Tre'Davious White	Dane Jackson	Ja'Marcus Ingram
PR	Brandon Codrington
KR	Brandon Codrington	Elijah Moore
LS	Reid Ferguson
K	Tyler Bass
RWR	Keon Coleman	Curtis Samuel	Kristian Wilkerson
DT	Ed Oliver	T.J. Sanders	DeWayne Carter
NT	DaQuan Jones	Deone Walker	Zion Logue
NB	Taron Johnson	Brandon Codrington
LWR	Joshua Palmer	Tyrell Shavers
FB	Reggie Gilliam