Saints vs. Bills Odds & Betting Predictions - September 28, 2025
Saints at Bills
5:00 pm • CBSSaints at Bills Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Saints 0-3 | +12.5 | +15.5-110 | o48.5-105 | +874 |
 Bills 3-0 | u46.5 | -15.5-110 | u48.5-115 | -1450 |
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Saints vs. Bills Expert Picks
Jim Sannes
Last 30d: 13-36-0 (-2.0u)
Over 48.5-105
1u
Have this total way high due as the Bills should be able to name their score, and I do think the Saints' offense will do at least *something*.
FTN Fantasy
Last 30d: 70-91-0 (-28.9u)
BUF -15.5-110
1u
Saints vs. Bills Previews & Analysis
Saints vs. Bills Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
Saints vs. Bills Public Betting Percentages
Betting Trends
- Bills are 3-0 in their last 5 games.
- Bills are 2-1 in their last 5 games against the spread
- Bills are 1-0 in their road games against the spread
- The totals have gone OVER in 2 of Bills' last 3 games
- The totals have gone OVER in 2 of Bills' 2 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Saints vs. Bills Injury Updates
Saints Injuries
- Taysom HillTE
Hill is out with knee
Out
- Chase YoungDE
Young is out with calf
Out
- Trevor PenningOL
Penning is out with toe
Out
- Jordan HowdenDB
Howden is questionable with oblique
Questionable
- Trey PalmerWR
Palmer is questionable with hamstring
Questionable
- Devaughn VeleWR
Vele is questionable with hip
Questionable
Bills Injuries
- Tyler BassK
Bass is out with hip
Out
Player Stats
- passing yards
Josh Allen755pyds - passing touchdownsJosh Allen5ptd
- rushing yards
James Cook284ryds - rushing touchdownsJames Cook4rtd
Depth Charts
| Starter | 2ND | 3RD | 4TH | |
|---|---|---|---|---|
| QB | Josh Allen | Mitchell Trubisky | Shane Buechele | |
| RB | James Cook | Ray Davis | Ty Johnson | Frank Gore |
| WR | Khalil Shakir | Elijah Moore | Stephen Gosnell | |
| TE | Dalton Kincaid | Dawson Knox | Jackson Hawes | Keleki Latu |
| LT | Dion Dawkins | Tylan Grable | Chase Lundt | Travis Clayton |
| LG | David Edwards | Kendrick Green | ||
| C | Connor McGovern | Sedrick Van Pran-Granger | ||
| RG | O'Cyrus Torrence | Alec Anderson | ||
| RT | Spencer Brown | Ryan Van Demark | ||
| LDE | Greg Rousseau | Landon Jackson | Javon Solomon | |
| WLB | Matt Milano | Dorian Williams | Keonta Jenkins | |
| MLB | Terrel Bernard | Joe Andreessen | Shaq Thompson | Jimmy Ciarlo |
| LCB | Christian Benford | Maxwell Hairston | Dorian Strong | |
| SS | Cole Bishop | Cam Lewis | Wande Owens | |
| FS | Taylor Rapp | Damar Hamlin | Jordan Hancock | |
| RCB | Tre'Davious White | Dane Jackson | Ja'Marcus Ingram | |
| PR | Brandon Codrington | |||
| KR | Brandon Codrington | Elijah Moore | ||
| LS | Reid Ferguson | |||
| RWR | Keon Coleman | Curtis Samuel | Kristian Wilkerson | |
| K | Tyler Bass | |||
| NB | Taron Johnson | Brandon Codrington | ||
| DT | Ed Oliver | T.J. Sanders | DeWayne Carter | |
| FB | Reggie Gilliam | |||
| LWR | Joshua Palmer | Tyrell Shavers | ||
| NT | DaQuan Jones | Deone Walker | Zion Logue |
Team Stats
Saints vs. Bills Odds Comparison
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Saints at Bills Team Totals
MatchupOverUnder | ||
|---|---|---|
Saints 0-3 | N/A | N/A |
Bills 3-0 | N/A | N/A |