49ers vs. Colts Odds & Betting Predictions - December 23, 2025
49ers at Colts
1:15 am • ESPN49ers at Colts Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
49ers 9-4 | N/A | N/A | N/A | |
Colts 8-4 | N/A | N/A | N/A | |

Lucas Oil StadiumIndianapolis
49ers vs. Colts Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
49ers vs. Colts Public Betting Percentages
Betting Trends
- Colts are 4-1 in their last 5 games.
- Colts are 3-2 in their last 5 games against the spread
- Colts are 3-2 in their road games against the spread
- The totals have gone OVER in 2 of Colts' last 5 games
- The totals have gone OVER in 3 of Colts' 6 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
49ers vs. Colts Injury Updates

49ers Injuries
- Brandon AiyukWR
Aiyuk is out with knee
Out
- Jacob CowingWR
Cowing is out with hamstring
Out

Colts Injuries
- Ashton DulinWR
Dulin is out with hamstring
Out
Player Stats
- passing yards
Daniel Jones3041pyds - passing touchdowns
Daniel Jones19ptd - rushing yards
Jonathan Taylor1282ryds - rushing touchdowns
Jonathan Taylor15rtd
Depth Charts
| Starter | 2ND | 3RD | 4TH | ||
|---|---|---|---|---|---|
| QB | Daniel Jones | Anthony Richardson | Riley Leonard | ||
| RB | Jonathan Taylor | Tyler Goodson | DJ Giddens | Ulysses Bentley | |
| WR | Josh Downs | Anthony Gould | Coleman Owen | ||
| TE | Tyler Warren | Mo Alie-Cox | Drew Ogletree | Will Mallory | Sean McKeon |
| LT | Bernhard Raimann | Jalen Travis | |||
| LG | Quenton Nelson | Dalton Tucker | |||
| C | Tanor Bortolini | Danny Pinter | |||
| RG | Matt Goncalves | Josh Sills | |||
| RT | Braden Smith | Luke Tenuta | |||
| LDE | Kwity Paye | Tyquan Lewis | JT Tuimoloau | ||
| RDE | Laiatu Latu | Samson Ebukam | Durell Nchami | ||
| WLB | Jaylon Carlies | Austin Ajiake | |||
| MLB | Zaire Franklin | Segun Olubi | |||
| LCB | Charvarius Ward | ||||
| SS | Nick Cross | Daniel Scott | |||
| FS | Cam Bynum | Rodney Thomas | Trey Washington | ||
| RCB | Jaylon Jones | Johnathan Edwards | |||
| P | Rigoberto Sanchez | ||||
| H | Rigoberto Sanchez | ||||
| PR | Anthony Gould | Josh Downs | Coleman Owen | ||
| KR | Anthony Gould | Ashton Dulin | Tyler Goodson | DJ Giddens | |
| LS | Luke Rhodes | ||||
| NB | Kenny Moore | Chris Lammons | |||
| K | Spencer Shrader | ||||
| RWR | Alec Pierce | ||||
| LWR | Michael Pittman | Ashton Dulin | Laquon Treadwell | ||
| NT | Grover Stewart | Neville Gallimore | Eric Johnson | ||
| DT | DeForest Buckner | Adetomiwa Adebawore | Tim Smith |
Team Stats
3154
YDS
2892
307/450
Comps/Atts
257/382
7.329
YPA
7.984
22/13
TDs/INTs
19/7
20/144
Sacks/Yards
22/158
30/48 62.5%
Redzone
34/52 65.39%
81/168 0%
3rd Down
55/135 0%
10/17 0%
4th Down
17/23 0%
49ers vs. Colts Odds Comparison
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49ers at Colts Team Totals
MatchupOverUnder | ||
|---|---|---|
49ers 9-4 | N/A | N/A |
Colts 8-4 | N/A | N/A |
