Giants vs. 49ers Odds & Betting Predictions - September 22, 2023
Giants at 49ers
12:15 am • Amazon Prime VideoGiants at 49ers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
---|---|---|---|---|
![]() Giants 1-0 | +10.5-110 | o43.5-110 | +425 | |
![]() 49ers 0-1 | -10.5-110 | u43.5-114 | -575 |

Levi's StadiumSanta Clara
Giants vs. 49ers Expert Picks

Steak Friend
Last 30d: 0-0-0 (+0.0u)
M.Breida Anytime TD Scorer+270
1.35u

Mjaybrod
Last 30d: 1-1-0 (-0.0u)
NYG +14.5 (Live)-126
1u
Feel it in my chicken bones

Chris Raybon
Last 30d: 1-0-0 (+0.9u)
J.Hyatt o9.5 Rec Yds-120
1u
Have him projected for closer to 2 catches and NYG could be trailing late

Sean Koerner
Last 30d: 10-12-0 (-0.9u)
P.Campbell u29.5 Rec Yds-120
1u

Joe Dellera
Last 30d: 30-49-3 (-0.3u)
J.Hyatt o49.5 Rec Yds+1125
0.25u
Sure - catch a bomb rook

Nick Giffen
Last 30d: 14-36-0 (+10.5u)
I.Hodgins o30.5 Rec Yds-110
1.1u

Dale Tanhardt
Last 30d: 3-16-0 (+1.8u)
G.Kittle Anytime TD Scorer+170
2.5u
G.Kittle 2+ TDs+1000
0.5u
G.Kittle 3+ TDs+7400
0.1u
G.Kittle First Touchdown Scorer+800
0.75u
B.Purdy First Touchdown Scorer+1700
0.25u
K.Juszczyk First Touchdown Scorer+3500
0.15u
D.Bellinger First Touchdown Scorer+5000
0.15u
L.Cager First Touchdown Scorer+8000
0.1u

Kyle Murray
Last 30d: 25-48-1 (-1.7u)
D.Samuel Anytime TD Scorer+110
1.1u
M.Breida o29.5 Rush Yds-125
1u
D.Jones u214.5 Pass Yds-115
0.87u
E.Mitchell Anytime TD Scorer+310
1u

Vegas Refund
Last 30d: 0-0-0 (+0.0u)
SF -10-110
1u

Nick Giffen
Last 30d: 14-36-0 (+10.5u)
SF u27.5-110
1.1u
Biggest Luck Team Total under of the week. Given on @ActionIsland
G.Kittle u50.5 Rec Yds-110
1.1u
Given on @ActionIsland

Firefighter Bets
Last 30d: 41-64-0 (-22.3u)
D.Jones o31.5 Pass Att-108
0.93u
B.Purdy u28.5 Pass Att-120
1u
M.Breida o2.5 Recs+130
1.3u
X.McKinney o5.5 Tackles + Ast+115
1.15u
YBK Picks.com
Last 30d: 9-19-2 (-20.1u)
Under 43.5-105
3u

Action Island
Last 30d: 0-0-0 (+0.0u)
G.Kittle u50.5 Rec Yds-120
1u
@nick_giffen
D.Jones u39.5 Rush Yds-110
0.91u
@GDAWG5000
M.Breida u31.5 Rush Yds-115
0.87u
@The_Oddsmaker

Steak Friend
Last 30d: 0-0-0 (+0.0u)
C.McCaffrey o80.5 Rush Yds-115
0.5u

Simon Hunter
Last 30d: 1-0-0 (+1.0u)
NYG +10.5-110
1u
Over 43.5-110
0.5u
D.Jones Anytime TD Scorer+260
1u

Mjaybrod
Last 30d: 1-1-0 (-0.0u)
J.Hyatt First Touchdown Scorer+9000
0.1u
Hyatt to the 20, 10, TOUCHDOWN!
M.Breida o2.5 Recs+130
1.3u
Giving it at plus money to scare us off
Over 43.5-110
1u
Gut play, somehow the Giants will score

Green Dot Daily
Last 30d: 0-0-0 (+0.0u)
E.Mitchell o29.5 Rush Yds-115
0.87u
@PropBomb
P.Campbell u15.5 Longest Reception-125
0.8u
@The_Oddsmaker

Prop Bomb 🏝
Last 30d: 0-0-0 (+0.0u)
E.Mitchell o29.5 Rush Yds-115
1u
Gave out on Green Dot Daily
- More workload. Shanahan admitted “We definitely got get Elijah [Mitchell] in there more”
- Short week, blowout potential, avg. 40.2 RushYds/g over in 5/7 single digit carry games
- NYG lead the league in explosive rush% - 8.5% plays that go for 15+ yards, and are 2nd in yards before contact

Prop Bet Guy
Last 30d: 0-0-0 (+0.0u)
B.Okereke o7.5 Tackles + Ast-145
1u

Sean Koerner
Last 30d: 10-12-0 (-0.9u)
P.Campbell u15.5 Longest Reception-125
1u
Bet365

Shady Biev
Last 30d: 0-1-0 (-3.0u)
D.Samuel First Touchdown Scorer+650
0.5u
My wife gave me this pick while making love
Over 43.5-110
1.1u
POINTS

The Degenerates
Last 30d: 53-46-3 (+2.9u)
Under 43.5-110
1u

Nicholas Parsons
Last 30d: 0-0-0 (+0.0u)
NYG +10.5-110
3.3u

Nick Martin
Last 30d: 2-2-0 (-0.5u)
D.Waller o4.5 Recs+110
0.5u
DK 1:31.

Joe Dellera
Last 30d: 30-49-3 (-0.3u)
E.Mitchell o74.5 Rush Yds+1075
0.25u
E.Mitchell o49.5 Rush Yds+300
0.25u
Just give me the alts
E.Mitchell Anytime TD Scorer+250
0.5u

Nick Martin
Last 30d: 2-2-0 (-0.5u)
E.Mitchell o29.5 Rush Yds-115
0.65u
DraftKings 12:37.

Royals Props
Last 30d: 0-0-0 (+0.0u)
G.Kittle o42.5 Rec Yds-120
1u

Jeremiah Rose
Last 30d: 8-18-0 (+0.2u)
E.Mitchell o26.5 Rush Yds-140
0.14u
Resorts World

Matthew Freedman
Last 30d: 0-0-0 (+0.0u)
NYG +10.5-111
1.1u
BetMGM - Projection: +9.5. For more, check out Fantasy Life.
Scott Rickenbach
Last 30d: 78-62-4 (+4.1u)
Under 44-110
0.91u

Shady Biev
Last 30d: 0-1-0 (-3.0u)
D.Waller Anytime TD Scorer+270
1u
Biev 🤝 Waller
Coke

Markus Markets
Last 30d: 11-11-1 (-1.7u)
E.Mitchell o26.5 Rush Yds-113
0.88u

Mjaybrod
Last 30d: 1-1-0 (-0.0u)
B.Okereke o7.5 Tackles + Ast-125
0.8u
Need my coin back from week 1
NYG +10.5-110
1u
Give SF the trophy if they cover tonight

Shady Biev
Last 30d: 0-1-0 (-3.0u)
NYG o16.5-105
1.05u
This hits easily somehow idk tho
E.Mitchell o26.5 Rush Yds-106
1u
Elijah Mitchell Biever

Mjaybrod
Last 30d: 1-1-0 (-0.0u)
D.Waller o4.5 Recs-110
1u
Biever Ramble POD

Markus Markets
Last 30d: 11-11-1 (-1.7u)
T.Hufanga o4.5 Tackles + Ast-148
1u

FTN Fantasy
Last 30d: 64-62-1 (+3.0u)
E.Mitchell o28.5 Rush Yds-115
0.87u
Follow all my picks at FTNBets.com!

Steak Friend
Last 30d: 0-0-0 (+0.0u)
NYG +10.5-111
1.11u
Scott Pritchard
Last 30d: 0-0-0 (+0.0u)
Under 44-109
0.92u

Nick Martin
Last 30d: 2-2-0 (-0.5u)
Under 44-110
0.91u
@The_Oddsmaker

Shady Biev
Last 30d: 0-1-0 (-3.0u)
D.Waller o4.5 Recs+110
2u
Ramble POD
6-0?
ASA Inc
Last 30d: 0-0-0 (+0.0u)
SF -10-110
0.91u

Brian Edwards
Last 30d: 0-0-0 (+0.0u)
SF o13.5 (1H)-140
0.71u
SF o27.5-107
0.93u

Sean Koerner
Last 30d: 10-12-0 (-0.9u)
Under 44.5-110
1u

Royals Props
Last 30d: 0-0-0 (+0.0u)
T.Hufanga o4.5 Tackles + Ast+100
1u

Kevin Thomas
Last 30d: 14-6-0 (+8.3u)
C.McCaffrey u113.5 Rush + Rec Yds-114
1u
SF -10.5-109
0.92u

Cam Is Money
Last 30d: 94-117-4 (-21.0u)
E.Mitchell o27.5 Rush Yds-114
0.88u
Gilles Gallant
Last 30d: 1-5-0 (-2.0u)
D.Samuel Anytime TD Scorer+130
1.3u
Bet at Bet365. Keeping it simple. CMC TD prices nearly unbettable and Deebo can make something out of nothing. Giants blitz a ton and play man coverage at high rate. Should lend itself well to easy dumpoffs to Deebo.

Mjaybrod
Last 30d: 1-1-0 (-0.0u)
C.McCaffrey u17.5 Rush Att-125
1u
Tailing token here what’s new

Royals Props
Last 30d: 0-0-0 (+0.0u)
D.Slayton o32.5 Rec Yds-110
1.1u

Milly Props
Last 30d: 0-0-0 (+0.0u)
D.Jones o31.5 Pass Att-108
0.93u

Markus Markets
Last 30d: 11-11-1 (-1.7u)
B.Purdy u29.5 Pass Att-114
1u

Bruce Marshall
Last 30d: 0-0-0 (+0.0u)
SF -10-111
0.9u

Nick Giffen
Last 30d: 14-36-0 (+10.5u)
R.Bell Anytime TD Scorer+2000
2u
Riding with my guy @GDAWG5000 on this
Gilles Gallant
Last 30d: 1-5-0 (-2.0u)
R.Bell Anytime TD Scorer+2000
2u
Bet at Bet365 on 09/19. Down to +850 at FD and +1000 at DK. Aiyuk questionable. Bell played majority of snaps when he was off field. Giants blitz and play man coverage at high rate which plays into Bell getting potential looks.

Brandon Anderson
Last 30d: 0-2-0 (-0.5u)
SF -10-109
0.92u
Week 3 Hot Read! 🎙
Niners have won 12 straight, 8 by 13+. Giants keep getting thrashed by great teams, can barely beat awful Cards. Worst run D in NFL last year. Blowout city.
Grabbing now cuz Saquon injured + NY OL a disaster so I think this line could rise quickly to 13+ for teaser protection.
PRO Insights

Giants
NYG Insights
- Featured Insight
The 49ers have rushed for 2,728 yards since the 2022 season -- sixth-most in NFL. The Giants have allowed 2,737 yards rushing since the 2022 season -- fourth-most in NFL.
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49ers
SF Insights
- Featured Insight
The Giants have scored on 67% of their drives in late and close games since Week 15 of the 2022 Season -- best in NFL. The 49ers defense has allowed scores on 38% of opponent drives in close and late situations since Week 15 of the 2022 Season -- tied for ninth-worst in NFL.
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Giants vs. 49ers Previews & Analysis
Giants vs. 49ers Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
Giants vs. 49ers Public Betting Percentages
Betting Trends
- 49ers are 2-3 in their last 5 games.
- 49ers are 2-3 in their last 5 games against the spread
- 49ers are 1-7 in their road games against the spread
- The totals have gone OVER in 2 of 49ers' last 5 games
- The totals have gone OVER in 5 of 49ers' 9 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Giants vs. 49ers Injury Updates

Giants Injuries

49ers Injuries
- Trevis GipsonLB
Gipson is out with ankle
Out
Team Stats
Giants vs. 49ers Odds Comparison
Could not load odds
Giants at 49ers Team Totals
MatchupOverUnder | ||
---|---|---|
![]() Giants 1-0 | o15.5-118 | u15.5+102 |
![]() 49ers 0-1 | o27.5+100 | u27.5-122 |